{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:03:22Z","timestamp":1792555402848,"version":"4.5.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Oral antibiotics are a mainstay of treatment for hidradenitis suppurativa (HS), primarily due to their anti-inflammatory and anti-microbial properties. There is a paucity of literature comparing how antibiotic prescribing patterns for HS patients differ between the emergency department (ED) and ambulatory care settings.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aims to compare antibiotic prescribing patterns for HS patients in the ED versus ambulatory care setting.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We utilized the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) to identify visits for HS patients in 2005-2016, 2018, and 2019. We performed multivariate logistic regression analysis to compare the likelihood of prescribing antibiotic therapy versus no antibiotic therapy between the ED and ambulatory care settings.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We identified a weighted total of 3,041,193 HS patient visits. Approximately 49.0% of ambulatory visits resulted in antibiotic prescriptions. The most frequently prescribed antibiotics in the ambulatory setting were tetracyclines (41.2%), clindamycin (35.9%), and trimethoprim\/sulfamethoxazole (21.6%). Approximately 74.7% of ED visits resulted in antibiotic prescriptions. The most frequently prescribed antibiotics in the ED setting were trimethoprim\/sulfamethoxazole (44.5%), beta-lactams (33.2%), and clindamycin (27.7%). Multivariate logistic regression demonstrated significantly higher odds of receiving antibiotics in ED visits compared to ambulatory care visits. (OR 3.88; 95% Cl, 1.28-11.77; <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Antibiotic class selection varied significantly between the ED and ambulatory settings. Additionally, ED visits were more likely to result in antibiotic prescriptions than ambulatory visits for HS patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0310651","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T17:21:28Z","timestamp":1747675288000},"page":"e0310651","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing antibiotic prescribing patterns for hidradenitis suppurativa between the emergency department and ambulatory care setting"],"prefix":"10.1371","volume":"20","author":[{"given":"Hannah","family":"Tolson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca 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issues","volume":"12","author":"E Molinelli","year":"2023","journal-title":"Antibiotics (Basel)"},{"issue":"2","key":"pone.0310651.ref007","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jaad.2020.12.089","article-title":"The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: results of a prospective European cohort study","volume":"85","author":"KR van Straalen","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"pone.0310651.ref008","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaad.2019.02.068","article-title":"North American clinical management guidelines for hidradenitis suppurativa: a publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management","volume":"81","author":"A Alikhan","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"pone.0310651.ref009","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/jdv.15332","article-title":"Rates of antibiotic resistance\/sensitivity in bacterial cultures of hidradenitis suppurativa patients","volume":"33","author":"V Bettoli","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"9","key":"pone.0310651.ref010","first-page":"562","article-title":"Hidradenitis suppurativa: rapid evidence review","volume":"100","author":"J Wipperman","year":"2019","journal-title":"Am Fam Physician"},{"key":"pone.0310651.ref011","author":"NAMCS\/NHAMCS","year":"March 4, 2019"},{"key":"pone.0310651.ref012","author":"NAMCS\/NHAMCS","year":"December 30, 2021"},{"issue":"2","key":"pone.0310651.ref013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/QCO.0000000000000814","article-title":"Current international and national guidelines for managing skin and soft tissue infections","volume":"35","author":"E Bouza","year":"2022","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"pone.0310651.ref014","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jid.2018.09.036","article-title":"Are bacteria infectious pathogens in hidradenitis suppurativa? debate at the symposium for hidradenitis suppurativa advances meeting, november 2017","volume":"139","author":"HB Naik","year":"2019","journal-title":"J Invest Dermatol"},{"issue":"4","key":"pone.0310651.ref015","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3947\/ic.2017.49.4.301","article-title":"Clinical guidelines for the antibiotic treatment for community-acquired skin and soft tissue infection","volume":"49","author":"YG Kwak","year":"2017","journal-title":"Infect Chemother"},{"issue":"11","key":"pone.0310651.ref016","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.16536","article-title":"Emergency doctor\u2019s ability to diagnose hidradenitis suppurativa","volume":"34","author":"D 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