{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:34:16Z","timestamp":1791254056469,"version":"4.1.0"},"reference-count":108,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007430","name":"National Fish and Wildlife Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007430","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Detroit Zoological Society"},{"DOI":"10.13039\/100023097","name":"State of Alaska","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100023097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012475","name":"Bureau of Ocean Energy Management","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Environmental changes associated with global warming create new opportunities for pathogen and parasite transmission in Arctic wildlife. As an apex predator ranging over large, remote areas, changes in pathogens and parasites in polar bears are a useful indicator of changing transmission dynamics in Arctic ecosystems. We examined prevalence and risk factors associated with exposure to parasites and viral and bacterial pathogens in Chukchi Sea polar bears. Serum antibodies to six pathogens were detected and prevalence increased between 1987\u20131994 and 2008\u20132017 for five: <jats:italic>Toxoplasma gondii<\/jats:italic>, <jats:italic>Neospora caninum<\/jats:italic>, <jats:italic>Francisella tularensis<\/jats:italic>, <jats:italic>Brucella abortus\/suis<\/jats:italic>, and canine distemper virus. Although bears have increased summer land use, this behavior was not associated with increased exposure. Higher prevalence of <jats:italic>F<\/jats:italic>. <jats:italic>tularensis<\/jats:italic>, <jats:italic>Coxiella burnetii<\/jats:italic>, and <jats:italic>B<\/jats:italic>. <jats:italic>abortus\/suis<\/jats:italic> antibodies in females compared to males, however, could be associated with terrestrial denning. Exposure was related to diet for several pathogens indicating increased exposure in the food web. Elevated white blood cell counts suggest a possible immune response to some pathogens. Given that polar bears face multiple stressors in association with climate change and are a subsistence food, further work is warranted to screen for signs of disease.<\/jats:p>","DOI":"10.1371\/journal.pone.0310973","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T17:21:57Z","timestamp":1729704117000},"page":"e0310973","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased pathogen exposure of a marine apex predator over three decades"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-8202","authenticated-orcid":true,"given":"Karyn D.","family":"Rode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Van Hemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah P.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Pabilonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora","family":"Ballweber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender P.","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"pone.0310973.ref001","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1126\/science.1063699","article-title":"Climate warming and disease risks for terrestrial and marine biota","volume":"296","author":"C. 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