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the SERCA2a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -reuptake pump. The R14\u0394-PLN mutation causes severe cardiomyopathy that is resistant to conventional treatment. Protein complexes and higher-order supercomplexes such as intercalated disk components and Ca\n                    <jats:sup>+2<\/jats:sup>\n                    -cycling domains underlie many critical cardiac functions, a subset of which may be disrupted by R14\u0394-PLN. Complexome profiling (CP) is a proteomics workflow for systematic analysis of high molecular weight (MW) protein complexes and supercomplexes. We hypothesize that R14\u0394-PLN may alter a subset of these assemblies, and apply CP workflows to explore these changes in presymptomatic R14\n                    <jats:sup>\u0394\/+<\/jats:sup>\n                    mice hearts. Ventricular tissues from presymptomatic 28wk-old WT and R14\n                    <jats:sup>\u0394\/+<\/jats:sup>\n                    mice were homogenized under non-denaturing conditions, fractionated by size-exclusion chromatography (SEC) with a linear MW-range exceeding 5 MDa, and subjected to quantitative data-independent acquisition mass spectrometry (DIA-MS) analysis. Unfortunately, current workflows for the systematic analysis of CP data proved ill-suited for use in cardiac samples. Most rely upon curated protein complex databases to provide ground-truth for analysis; however, these are derived primarily from cancerous or immortalized cell lines and, consequently, cell-type specific complexes (including cardiac-specific machinery potentially affected in R14\u0394-PLN hearts) are poorly covered. We thus developed PERCOM: a novel CP data-analysis strategy that does not rely upon these databases and can, furthermore, be implemented on widely available spreadsheet software. Applying PERCOM to our CP dataset resulted in the identification of 296 proteins with disrupted elution profiles. Hits were significantly enriched for mitochondrial and intercalated disk (ICD) supercomplex components. Changes to mitochondrial supercomplexes were associated with reduced expression of mitochondrial proteins and maximal oxygen consumption rate. The observed alterations to mitochondrial and ICD supercomplexes were replicated in a second cohort of \u201cjuvenile\u201d 9wk-old mice. These early-stage changes to key cardiac machinery may contribute to R14\u0394-PLN pathogenesis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0311203","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T13:57:17Z","timestamp":1729778237000},"page":"e0311203","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14\u0394\/+ mice hearts"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1361-0382","authenticated-orcid":true,"given":"Brian","family":"Foo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Amedei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surmeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Jaawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Boshnakovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Gall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9140","authenticated-orcid":true,"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman H. 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Res"},{"key":"pone.0311203.ref002","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/342090a0","article-title":"Nature and site of phospholamban regulation of the Ca 2 + pump of sarcoplasmic reticulum","volume":"342","author":"P James","year":"1989","journal-title":"Nature"},{"key":"pone.0311203.ref003","first-page":"1410","article-title":"Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban","volume":"299","author":"JP Schmitt","year":"2003","journal-title":"Science (1979)."},{"key":"pone.0311203.ref004","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1172\/JCI17892","article-title":"Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human","volume":"111","author":"K Haghighi","year":"2003","journal-title":"Journal of Clinical Investigation"},{"key":"pone.0311203.ref005","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1073\/pnas.0510519103","article-title":"A 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Frank","year":"2017"},{"key":"pone.0311203.ref022","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/CIRCULATIONAHA.119.039642","article-title":"Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation","volume":"140","author":"KM Alsina","year":"2019","journal-title":"Circulation"},{"key":"pone.0311203.ref023","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/cvr\/cvs195","article-title":"Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells","volume":"95","author":"Wu H Di","year":"2012","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref024","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cardiores.2004.01.033","article-title":"Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis","volume":"62","author":"JR De Groot","year":"2004","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref025","first-page":"491","article-title":"Arrhythmogenic cardiomyopathy: a disease of intercalated discs","volume-title":"Cell and Tissue Research","author":"M Calore","year":"2015"},{"key":"pone.0311203.ref026","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/biot.201100155","article-title":"Recombinant protein expression and purification: A comprehensive review of affinity tags and microbial applications.","author":"CL Young","year":"2012","journal-title":"Biotechnology Journal"},{"key":"pone.0311203.ref027","doi-asserted-by":"crossref","first-page":"102605","DOI":"10.1016\/j.xpro.2023.102605","article-title":"Protocol to study human mitochondrial ribosome using quantitative density gradient analysis by mass spectrometry and complexome profiling analysis.","volume":"4","author":"P P\u00e1len\u00edkov\u00e1","year":"2023","journal-title":"STAR Protoc"},{"key":"pone.0311203.ref028","first-page":"1862","article-title":"Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes","author":"P P\u00e1len\u00edkov\u00e1","year":"2021","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"pone.0311203.ref029","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.cmet.2012.08.009","article-title":"Complexome profiling identifies TMEM126B as a component of the mitochondrial complex i assembly complex","volume":"16","author":"H Heide","year":"2012","journal-title":"Cell Metab"},{"key":"pone.0311203.ref030","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1074\/mcp.M000038-MCP201","article-title":"Megadalton complexes in the chloroplast stroma of Arabidopsis thaliana characterized by size exclusion chromatography, mass spectrometry, and hierarchical clustering","volume":"9","author":"PDB Olinares","year":"2010","journal-title":"Molecular and Cellular Proteomics"},{"key":"pone.0311203.ref031","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nmeth.2131","article-title":"A high-throughput approach for measuring temporal changes in the interactome.","volume":"9","author":"AR Kristensen","year":"2012","journal-title":"Nat Methods"},{"key":"pone.0311203.ref032","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1074\/mcp.M113.032367","article-title":"Characterization of native protein complexes and protein isoform variation using sizefractionation- based quantitative proteomics","volume":"12","author":"KJ Kirkwood","year":"2013","journal-title":"Molecular and Cellular Proteomics"},{"key":"pone.0311203.ref033","first-page":"4","article-title":"mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes","author":"H Amedei","year":"2024","journal-title":"Frontiers in Analytical Science"},{"key":"pone.0311203.ref034","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41596-020-0332-6","article-title":"Complex-centric proteome profiling by SEC-SWATH-MS for the parallel detection of hundreds of protein complexes","volume":"15","author":"I Bludau","year":"2020","journal-title":"Nat Protoc"},{"key":"pone.0311203.ref035","first-page":"15","article-title":"Complex\u2010centric proteome profiling by SEC \u2010 SWATH \u2010 MS","author":"M Heusel","year":"2019","journal-title":"Mol Syst Biol"},{"key":"pone.0311203.ref036","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1074\/mcp.TIR119.001434","article-title":"ComplexBrowser: A tool for identification and quantification of protein complexes in large-scale proteomics datasets","volume":"18","author":"W Michalak","year":"2019","journal-title":"Molecular and Cellular Proteomics"},{"key":"pone.0311203.ref037","doi-asserted-by":"crossref","first-page":"D539","DOI":"10.1093\/nar\/gkac1015","article-title":"CORUM: the comprehensive resource of mammalian protein complexes-2022","volume":"51","author":"G Tsitsiridis","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"pone.0311203.ref038","doi-asserted-by":"crossref","first-page":"D578","DOI":"10.1093\/nar\/gkab991","article-title":"Complex Portal 2022: New curation frontiers","volume":"50","author":"BHM Meldal","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"pone.0311203.ref039","first-page":"18","article-title":"A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE)","author":"RG Stacey","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"pone.0311203.ref040","first-page":"9","article-title":"Protein Complex Identification and quantitative complexome by CN-PAGE.","author":"M Gorka","year":"2019","journal-title":"Sci Rep."},{"key":"pone.0311203.ref041","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.119.043502","article-title":"Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.","volume":"144","author":"N Raad","year":"2021","journal-title":"Circulation"},{"key":"pone.0311203.ref042","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1161\/CIRCRESAHA.119.316547","article-title":"Caveolin3 Stabilizes McT1-Mediated Lactate\/Proton Transport in Cardiomyocytes","volume":"128","author":"J Peper","year":"2021","journal-title":"Circ Res"},{"key":"pone.0311203.ref043","first-page":"11","article-title":"A salvage pathway maintains highly functional respiratory complex I.","author":"K Szczepanowska","year":"2020","journal-title":"Nat Commun"},{"key":"pone.0311203.ref044","first-page":"118","article-title":"Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain","author":"JF Hevler","year":"2021","journal-title":"PNAS"},{"key":"pone.0311203.ref045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/a19600193","article-title":"Size Exclusion Chromatography.","volume":"68","author":"HG Barth","year":"1996","journal-title":"Anal Chem"},{"key":"pone.0311203.ref046","article-title":"Na,K-ATPase solubilized using only C 12 E 8","author":"HL Santos","year":"2002","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"pone.0311203.ref047","first-page":"13","article-title":"14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban","author":"J Menzel","year":"2020","journal-title":"Science Signalling"},{"key":"pone.0311203.ref048","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1016\/S0021-9258(17)38028-6","article-title":"Enzymatically Active Ca2+ATPase from Sarcoplasmic Reticulum Membranes, Solubilized by Nonionic Detergents","volume":"263","author":"M Le Maire","year":"1978","journal-title":"Journal of Biological Chemistry"},{"key":"pone.0311203.ref049","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1021\/jasms.3c00230","article-title":"A Critical Evaluation of Detergent Exchange Methodologies for Membrane Protein Native Mass Spectrometry","volume":"34","author":"I Levesque","year":"2023","journal-title":"J Am Soc Mass Spectrom"},{"key":"pone.0311203.ref050","doi-asserted-by":"crossref","first-page":"13361","DOI":"10.1021\/acs.analchem.3c02788","article-title":"Infrared Photoactivation Enables Improved Native Top-Down Mass Spectrometry of Transmembrane Proteins","volume":"95","author":"BR Juliano","year":"2023","journal-title":"Anal Chem"},{"key":"pone.0311203.ref051","article-title":"Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC","author":"H Yoshikawa","year":"2018","journal-title":"Elife"},{"key":"pone.0311203.ref052","article-title":"Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of cardiac calcium handling","author":"SR Cleary","year":"2023","journal-title":"BioRxiv"},{"key":"pone.0311203.ref053","first-page":"13","article-title":"Impairment of the ER\/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation","author":"F Cuello","year":"2021","journal-title":"EMBO Mol Med"},{"key":"pone.0311203.ref054","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1093\/bioinformatics\/btz025","article-title":"COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome","volume":"35","author":"J Van Strien","year":"2019","journal-title":"Bioinformatics"},{"key":"pone.0311203.ref055","first-page":"914","article-title":"The structural basis of T-cell receptor (TCR) activation: An enduring enigma","volume-title":"Journal of Biological Chemistry","author":"RA Mariuzza","year":"2020"},{"key":"pone.0311203.ref056","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nature13566","article-title":"Crystal structure of the human COP9 signalosome","volume":"512","author":"GM Lingaraju","year":"2014","journal-title":"Nature"},{"key":"pone.0311203.ref057","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"G S\u00f6hl","year":"2004","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref058","first-page":"166","article-title":"Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes.","volume-title":"Annals of the New York Academy of Sciences","author":"PA Insel","year":"2005"},{"key":"pone.0311203.ref059","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nsmb.3460","article-title":"Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain","volume":"24","author":"JA Letts","year":"2017","journal-title":"Nat Struct Mol Biol"},{"key":"pone.0311203.ref060","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.cell.2012.08.011","article-title":"A census of human soluble protein complexes","volume":"150","author":"PC Havugimana","year":"2012","journal-title":"Cell"},{"key":"pone.0311203.ref061","first-page":"13","article-title":"Scalable multiplex co-fractionation\/mass spectrometry platform for accelerated protein interactome discovery","author":"PC Havugimana","year":"2022","journal-title":"Nat Commun"},{"key":"pone.0311203.ref062","first-page":"19","article-title":"Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I","author":"E Maranzana","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"pone.0311203.ref063","first-page":"1567","article-title":"Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain","volume":"340","author":"E Lapuente-Brun","year":"2013","journal-title":"Science (1979)."},{"key":"pone.0311203.ref064","first-page":"63","article-title":"The metabolic state of the heart regulates mitochondrial supercomplex abundance in mice","author":"Y Zheng","year":"2023","journal-title":"Redox Biol"},{"key":"pone.0311203.ref065","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41422-019-0208-x","article-title":"NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly","volume":"29","author":"T Hou","year":"2019","journal-title":"Cell Res"},{"key":"pone.0311203.ref066","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvn184","article-title":"Cardiac mitochondria in heart failure: Decrease in respirasomes and oxidative phosphorylation","volume":"80","author":"MG Rosca","year":"2008","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref067","first-page":"27","article-title":"Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia\u2013Reperfusion","author":"Sehwan Jang","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"pone.0311203.ref068","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: More genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"H Mi","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"pone.0311203.ref069","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.201107053","article-title":"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria","volume":"195","author":"S Hoppins","year":"2011","journal-title":"Journal of Cell Biology"},{"key":"pone.0311203.ref070","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cmet.2015.04.006","article-title":"Mic10 Oligomerizes to Bend Mitochondrial Inner Membranes at Cristae Junctions","volume":"21","author":"M Barbot","year":"2015","journal-title":"Cell Metab"},{"key":"pone.0311203.ref071","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1091\/mbc.e11-10-0831","article-title":"The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB\/SAM complex in mitochondria","volume":"23","author":"C K\u00f6rner","year":"2012","journal-title":"Mol Biol Cell"},{"key":"pone.0311203.ref072","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1073\/pnas.1617220114","article-title":"Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry","volume":"114","author":"DK Schweppe","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0311203.ref073","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41418-019-0345-2","article-title":"Sam50\u2013Mic19\u2013Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact","volume":"27","author":"J Tang","year":"2020","journal-title":"Cell Death Differ"},{"key":"pone.0311203.ref074","article-title":"MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture","author":"JR Friedman","year":"2015","journal-title":"Elife"},{"key":"pone.0311203.ref075","first-page":"3","article-title":"MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes","author":"R Anand","year":"2020","journal-title":"Life Sci Alliance"},{"key":"pone.0311203.ref076","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cmet.2015.04.007","article-title":"Central Role of Mic10 in the Mitochondrial Contact Site and Cristae Organizing System","volume":"21","author":"M Bohnert","year":"2015","journal-title":"Cell Metab"},{"key":"pone.0311203.ref077","first-page":"219","article-title":"MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites","author":"PS Tirrell","year":"2020","journal-title":"Journal of Cell Biology"},{"key":"pone.0311203.ref078","first-page":"154","article-title":"Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation","author":"J Qiu","year":"2013","journal-title":"Cell"},{"key":"pone.0311203.ref079","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1091\/mbc.e04-12-1086","article-title":"Mature DIABLO\/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane","volume":"16","author":"L Burri","year":"2005","journal-title":"Mol Biol Cell"},{"key":"pone.0311203.ref080","first-page":"26","article-title":"Considerations for using isolated cell systems to understand cardiac metabolism and biology","volume-title":"Journal of Molecular and Cellular Cardiology","author":"LA McNally","year":"2021"},{"key":"pone.0311203.ref081","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature19754","article-title":"Accessory subunits are integral for assembly and function of human mitochondrial complex i","volume":"538","author":"DA Stroud","year":"2016","journal-title":"Nature"},{"key":"pone.0311203.ref082","first-page":"5","article-title":"The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis.","author":"JG Van Vranken","year":"2016","journal-title":"Elife"},{"key":"pone.0311203.ref083","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature20157","article-title":"Mechanism of super-assembly of respiratory complexes III and IV","volume":"539","author":"S Cogliati","year":"2016","journal-title":"Nature"},{"key":"pone.0311203.ref084","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.celrep.2018.10.058","article-title":"Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics","volume":"25","author":"T Lobo-Jarne","year":"2018","journal-title":"Cell Rep"},{"key":"pone.0311203.ref085","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s42255-022-00655-0","article-title":"COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.","volume":"4","author":"G Benegiamo","year":"2022","journal-title":"Nat Metab"},{"key":"pone.0311203.ref086","first-page":"11","article-title":"Impaired right ventricular calcium cycling is an early risk factor in r14del-phospholamban arrhythmias.","author":"K Haghighi","year":"2021","journal-title":"J Pers Med"},{"key":"pone.0311203.ref087","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/CIRCULATIONAHA.123.064513","article-title":"SERCA2a Protein Levels Are Unaltered in Human Heart Failure","volume":"148","author":"I Ragone","year":"2023","journal-title":"Circulation"},{"key":"pone.0311203.ref088","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1152\/physrev.00021.2022","article-title":"The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes","volume":"103","author":"MS Nielsen","year":"2023","journal-title":"Physiol Rev"},{"key":"pone.0311203.ref089","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","article-title":"Macrophages Facilitate Electrical Conduction in the Heart","volume":"169","author":"M Hulsmans","year":"2017","journal-title":"Cell"},{"key":"pone.0311203.ref090","first-page":"12","article-title":"Cardiac macrophages prevent sudden death during heart stress","author":"J Sugita","year":"2021","journal-title":"Nat Commun"},{"key":"pone.0311203.ref091","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/CIRCRESAHA.110.227421","article-title":"Enhanced fibroblast-myocyte interactions in response to cardiac injury","volume":"107","author":"C Vasquez","year":"2010","journal-title":"Circ Res"},{"key":"pone.0311203.ref092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.120.019338","article-title":"Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease","volume":"10","author":"C Hall","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"pone.0311203.ref093","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/01.RES.0000241482.19382.c6","article-title":"Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"99","author":"Z Yang","year":"2006","journal-title":"Circ Res"},{"key":"pone.0311203.ref094","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/509122","article-title":"Arrhythmogenic Right Ventricular Dysplasia\/Cardiomyopathy Associated with Mutations in the Desmosomal Gene Desmocollin-2","volume":"79","author":"P Syrris","year":"2006","journal-title":"The American Journal of Human Genetics"},{"key":"pone.0311203.ref095","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCULATIONAHA.104.532234","article-title":"Novel mutation in desmoplakin causes arrhythmogenic left ventricular cardiomyopathy","volume":"112","author":"M Norman","year":"2005","journal-title":"Circulation"},{"key":"pone.0311203.ref096","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.RES.0000181132.11393.18","article-title":"Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis","volume":"97","author":"J Li","year":"2005","journal-title":"Circ Res"},{"key":"pone.0311203.ref097","doi-asserted-by":"crossref","first-page":"E003097","DOI":"10.1161\/CIRCGEN.120.003097","article-title":"Cadherin 2-Related Arrhythmogenic Cardiomyopathy: Prevalence and Clinical Features.","volume":"14","author":"A Ghidoni","year":"2021","journal-title":"Circ Genom Precis Med."},{"key":"pone.0311203.ref098","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.0000156274.72390.2c","article-title":"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure","volume":"96","author":"I Kostetskii","year":"2005","journal-title":"Circ Res"},{"key":"pone.0311203.ref099","first-page":"10","article-title":"Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy.","author":"BM Mayosi","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"pone.0311203.ref100","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/hmg\/ddt508","article-title":"Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model","volume":"23","author":"RC Lyon","year":"2014","journal-title":"Hum Mol Genet"},{"key":"pone.0311203.ref101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/CIRCULATIONAHA.111.057224","article-title":"Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death","volume":"125","author":"DW Van Norstrand","year":"2012","journal-title":"Circulation"},{"key":"pone.0311203.ref102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a004994","article-title":"Integrin structure, activation, and interactions.","volume":"3","author":"ID Campbell","year":"2011","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"pone.0311203.ref103","article-title":"Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact","author":"J Dave","year":"2022","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref104","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: Relating their ages","author":"S Dutta","year":"2016","journal-title":"Life Sciences. Elsevier Inc."},{"key":"pone.0311203.ref105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","article-title":"Oxidative stress caused by mitochondrial calcium overload","volume":"1201","author":"TI Peng","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"pone.0311203.ref106","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"G Santulli","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0311203.ref107","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.1073\/pnas.1300410110","article-title":"Mitochondrial calcium uptake","volume":"110","author":"GS B Williams","year":"2013","journal-title":"PNAS"},{"key":"pone.0311203.ref108","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1161\/CIRCRESAHA.119.315891","article-title":"The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications","volume":"126","author":"DA Eisner","year":"2020","journal-title":"Circ Res"},{"key":"pone.0311203.ref109","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"S Kaushik","year":"2015","journal-title":"Nat Med"},{"key":"pone.0311203.ref110","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrcardio.2017.89","article-title":"Proteostasis in cardiac health and disease","volume":"14","author":"RH Henning","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"pone.0311203.ref111","first-page":"5","article-title":"Endoplasmic reticulum protein targeting of phospholamban: A common role for an N-terminal di-arginine motif in ER retention?","author":"P Sharma","year":"2010","journal-title":"PLoS One."},{"key":"pone.0311203.ref112","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.yjmcc.2011.11.012","article-title":"The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na\/K-ATPase","volume":"52","author":"K Haghighi","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"pone.0311203.ref113","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.embor.7400480","article-title":"Hide and run: Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins","volume":"6","author":"K Michelsen","year":"2005","journal-title":"EMBO Rep"},{"key":"pone.0311203.ref114","first-page":"2106","article-title":"Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes","volume":"127","author":"EC Arakel","year":"2014","journal-title":"J Cell Sci"},{"key":"pone.0311203.ref115","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0092-8674(00)80487-0","article-title":"The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity","volume":"91","author":"MB Yaffe","year":"1997","journal-title":"Cell"},{"key":"pone.0311203.ref116","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1152\/physiol.00042.2010","article-title":"Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport.","volume":"26","author":"AJ Smith","year":"2011","journal-title":"Physiology"},{"key":"pone.0311203.ref117","first-page":"153","article-title":"Intercalated disk nanoscale structure regulates cardiac conduction","author":"N Moise","year":"2021","journal-title":"Journal of General Physiology"},{"key":"pone.0311203.ref118","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/01.RES.0000046237.54156.0A","article-title":"Localization of sodium channels in intercalated disks modulates cardiac conduction","volume":"91","author":"JP Kucera","year":"2002","journal-title":"Circ Res"},{"key":"pone.0311203.ref119","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1086\/521633","article-title":"A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy","volume":"81","author":"A Asimaki","year":"2007","journal-title":"Am J Hum Genet"},{"key":"pone.0311203.ref120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/cvr\/cvs219","article-title":"Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes","volume":"95","author":"S Rizzo","year":"2012","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref121","first-page":"11","article-title":"Disorganization of intercalated discs in dilated cardiomyopathy","author":"Y Ito","year":"2021","journal-title":"Sci Rep"},{"key":"pone.0311203.ref122","article-title":"Calpain Regulation and Dysregulation\u2014Its Effects on the Intercalated Disk.","volume-title":"International Journal of Molecular Sciences","author":"MW Yoder","year":"2023"},{"key":"pone.0311203.ref123","doi-asserted-by":"crossref","first-page":"19408","DOI":"10.1074\/jbc.M114.567206","article-title":"Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling","volume":"289","author":"Y Kudo-Sakamoto","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"pone.0311203.ref124","article-title":"Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation","author":"BJJM Brundel","year":"2002","journal-title":"Cardiovasc Res"},{"key":"pone.0311203.ref125","first-page":"12","article-title":"Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes","author":"G Weninger","year":"2022","journal-title":"Sci Rep"},{"key":"pone.0311203.ref126","first-page":"3","article-title":"Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure","author":"CYC Wu","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"pone.0311203.ref127","first-page":"171","article-title":"New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by","volume":"3","author":"G Weninger","year":"2022","journal-title":"Calpain. J Cell Signal"},{"key":"pone.0311203.ref128","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s12276-022-00800-5","article-title":"Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis","volume":"54","author":"B Qi","year":"2022","journal-title":"Exp Mol Med"},{"key":"pone.0311203.ref129","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/HYPERTENSIONAHA.109.130351","article-title":"Mitochondria-targeted antioxidant mitoq10 improves endothelial function and attenuates cardiac hypertrophy","volume":"54","author":"D Graham","year":"2009","journal-title":"Hypertension"},{"key":"pone.0311203.ref130","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.2010.05627.x","article-title":"Animal and human studies with the mitochondria-targeted antioxidant MitoQ","volume":"1201","author":"RAJ Smith","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"pone.0311203.ref131","first-page":"10","article-title":"Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide","author":"MA Daubert","year":"2017","journal-title":"Circ Heart Fail"},{"key":"pone.0311203.ref132","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s12035-020-01926-1","article-title":"The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer\u2019s Disease and Parkinson\u2019s Disease","volume":"7","author":"GM Compagnoni","year":"2020","journal-title":"Mol Neurobiol"},{"key":"pone.0311203.ref133","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2018.01.012","article-title":"MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload","volume":"117","author":"RF Ribeiro Junior","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"pone.0311203.ref134","first-page":"11","article-title":"Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress","author":"V. Souza-Neto F","year":"2022","journal-title":"Antioxidants"},{"key":"pone.0311203.ref135","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double-blind, placebo-controlled study to assess the mitochondria- targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease","volume":"25","author":"BJ Snow","year":"2010","journal-title":"Movement Disorders"},{"key":"pone.0311203.ref136","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1478-3231.2010.02250.x","article-title":"The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients","volume":"30","author":"EJ Gane","year":"2010","journal-title":"Liver International"},{"key":"pone.0311203.ref137","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/01.mca.0000236285.71683.b6","article-title":"Potent mitochondria-targeted peptides reduce myocardial infarction in rats","volume":"18","author":"J Cho","year":"2007","journal-title":"Coron Artery Dis"},{"key":"pone.0311203.ref138","first-page":"603","article-title":"Chapter 34 Detergents. An Overview","volume-title":"Methods in Enzymology","author":"D Linke","year":"2009"},{"key":"pone.0311203.ref139","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1021\/ac060279n","article-title":"Analysis of peptide MS\/MS spectra from large-scale proteomics experiments using spectrum libraries","volume":"78","author":"BE Frewen","year":"2006","journal-title":"Anal Chem"},{"key":"pone.0311203.ref140","first-page":"9","article-title":"Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones","author":"J Neef","year":"2018","journal-title":"Nat Commun"},{"key":"pone.0311203.ref141","article-title":"Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles","author":"E Wagner","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"pone.0311203.ref142","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1002\/pmic.201300035","article-title":"Increased proteome coverage by combining PAGE and peptide isoelectric focusing: Comparative study of gel-based separation approaches","volume":"13","author":"I Atanassov","year":"2013","journal-title":"Proteomics"},{"key":"pone.0311203.ref143","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1021\/acs.jproteome.5b00932","article-title":"Parallel accumulation-serial fragmentation (PASEF): Multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device","volume":"14","author":"F Meier","year":"2015","journal-title":"J Proteome Res"},{"key":"pone.0311203.ref144","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1074\/mcp.TIR118.000900","article-title":"Online parallel accumulation\u2013serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer","volume":"17","author":"F Meier","year":"2018","journal-title":"Molecular and Cellular Proteomics"},{"key":"pone.0311203.ref145","first-page":"21","article-title":"Rapid and In-Depth Coverage of the (Phospho-) Proteome With Deep Libraries and Optimal Window Design for dia-PASEF","author":"P Skowronek","year":"2022","journal-title":"Molecular and Cellular Proteomics"},{"key":"pone.0311203.ref146","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nprot.2006.62","article-title":"Blue native PAGE","volume":"1","author":"I Wittig","year":"2006","journal-title":"Nat Protoc"},{"key":"pone.0311203.ref147","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2307\/2331507","article-title":"On the laws of inheritance in man: I. Inheritance of physical characters","volume":"2","author":"K Pearson","year":"1903","journal-title":"Biometrika"},{"key":"pone.0311203.ref148","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","article-title":"UniProt: the Universal Protein Knowledgebase in 2023","volume":"51","author":"A Bateman","year":"2023","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0311203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T13:57:57Z","timestamp":1729778277000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0311203"}},"subtitle":[],"editor":[{"given":"Peng","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":148,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0311203","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.21.586093","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}