{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:07:19Z","timestamp":1790791639908,"version":"4.1.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-25-00080"],"award-info":[{"award-number":["24-25-00080"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Three food-borne trematodes\u2014<jats:italic>Opisthorchis felineus<\/jats:italic>, <jats:italic>Opisthorchis viverrini<\/jats:italic>, and <jats:italic>Clonorchis sinensis<\/jats:italic>\u2014are closely related epidemiologically important species. Despite the similarity of their life cycles, these liver flukes also have marked differences in the geographical range, helminth biology, and hepatobiliary disorders. <jats:italic>O<\/jats:italic>. <jats:italic>viverrini<\/jats:italic> and <jats:italic>C<\/jats:italic>. <jats:italic>sinensi<\/jats:italic>s are classified as Group 1 biological carcinogens while <jats:italic>O<\/jats:italic>. <jats:italic>felineus<\/jats:italic> is not. Direct comparisons of systemic response to the liver fluke infections are unexplored aspects. This study was carried out to identify species-specific liver and kidney responses in the hamster models after the infection with one of the three liver flukes. Liver periductal-fibrosis development was similar between hamsters infected with <jats:italic>O<\/jats:italic>. <jats:italic>felineus<\/jats:italic> or <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic>, whereas biliary intraepithelial neoplasia development was noticed predominantly in <jats:italic>O<\/jats:italic>. <jats:italic>viverrini<\/jats:italic>\u2013infected ones. Species-specific renal damage was detected, including progression of interstitial fibrosis and IgA deposition in glomeruli of <jats:italic>O<\/jats:italic>. <jats:italic>felineus<\/jats:italic>\u2013infected hamsters and <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic>\u2013infected ones. A strong correlation (R = 0.63; P = 0.0001) was found between periductal fibrosis in the liver and kidney interstitial fibrosis. Future comparative studies are needed to elucidate the development of serious complications during the long term of the infection, as well as under the influence of additional factors, including concomitant infections and the use of dimethylnitrosamine to clarify the mechanisms underlying the liver fluke-associated carcinogenesis. Thus, our findings may stimulate new comparative studies on the pathogenicity.<\/jats:p>","DOI":"10.1371\/journal.pone.0311481","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T19:17:25Z","timestamp":1733426245000},"page":"e0311481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Species-specific renal and liver responses during infection with food-borne trematodes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-6976","authenticated-orcid":true,"given":"Oxana G.","family":"Zaparina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav K.","family":"Kapushchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Lishai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y.","family":"Pakharukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"pone.0311481.ref001","volume-title":"\u2018Top Ten\u2019 List of Food-Borne Parasites Released (Internet)","author":"Food and Agriculture Organization of the United Nations\/World Health Organization (FAO\/WHO)","year":"2014"},{"issue":"10","key":"pone.0311481.ref002","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1017\/S0031182022000397","article-title":"Similarities and differences among the Opisthorchiidae liver flukes: insights from Opisthorchis felineus","volume":"149","author":"MY Pakharukova","year":"2022","journal-title":"Parasitology"},{"issue":"1","key":"pone.0311481.ref003","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.parint.2011.07.006","article-title":"Comparative cytogenetics of opisthorchid species (Trematoda, Opisthorchiidae)","volume":"61","author":"KS Zadesenets","year":"2012","journal-title":"Parasitology International"},{"key":"pone.0311481.ref004","doi-asserted-by":"crossref","first-page":"e59755","DOI":"10.7554\/eLife.59755","article-title":"Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia","volume":"10","author":"Y-J Feng","year":"2021","journal-title":"eLife"},{"key":"pone.0311481.ref005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actatropica.2017.11.018","article-title":"Opisthorchis felineus infection prevalence in Western Siberia: A review of Russian literature","volume":"178","author":"OS Fedorova","year":"2018","journal-title":"Acta Tropica"},{"key":"pone.0311481.ref006","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.rvsc.2020.10.024","article-title":"Foodborne zoonotic parasites of the family Opisthorchiidae","volume":"135","author":"W Saijuntha","year":"2021","journal-title":"Res Vet Sci"},{"key":"pone.0311481.ref007","doi-asserted-by":"crossref","first-page":"106545","DOI":"10.1016\/j.actatropica.2022.106545","article-title":"Epidemiology and determinants of Clonorchis sinensis infection: A community-based study in southeastern China","volume":"233","author":"MB Qian","year":"2022","journal-title":"Acta Trop"},{"key":"pone.0311481.ref008","first-page":"1","article-title":"Biological agents. 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