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We have previously shown that the non-aromatizable androgen, 11-ketotestosterone (11-KT), both advances ovarian follicle growth in vivo and dramatically alters the primary growth ovarian transcriptome in coho salmon. Many of the transcriptomic changes pointed towards 11-KT driving process associated with the transition to a secondary growth phenotype. In the current study, we implanted previtellogenic early secondary growth coho salmon with cholesterol pellets containing 11-KT and performed RNA-Seq on ovarian tissue after 3 days in order to identify alterations to the ovarian transcriptome in early secondary growth. We identified 8,707 contiguous sequences (contigs) that were differentially expressed (DE) between control and 11-KT implanted fish and were able to collapse those to 3,853 gene-level IDs, more than a 3-fold more DE contigs than at the primary growth stage we reported previously. These contigs included genes encoding proteins involved in steroidogenesis, vitellogenin and lipid uptake, follicle stimulating hormone signaling, growth factor signaling, and structural proteins, suggesting androgens continue to promote previtellogenic secondary growth.<\/jats:p>","DOI":"10.1371\/journal.pone.0311628","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T17:25:22Z","timestamp":1728494722000},"page":"e0311628","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["In vivo treatment with a non-aromatizable androgen rapidly alters the ovarian transcriptome of previtellogenic secondary growth coho salmon (Onchorhynchus kisutch)"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1388-4982","authenticated-orcid":true,"given":"Christopher","family":"Monson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Forsgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"issue":"3","key":"pone.0311628.ref001","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ygcen.2009.05.022","article-title":"Oogenesis in teleosts: How fish eggs are formed","volume":"165","author":"E Lubzens","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"pone.0311628.ref002","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquaculture.2016.10.029","article-title":"Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development","volume":"472","author":"E Lubzens","year":"2017","journal-title":"Aquaculture"},{"issue":"3","key":"pone.0311628.ref003","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1095\/biolreprod.111.098772","article-title":"Stage-specific effects of androgens and estradiol-17beta on the development of late primary and early secondary ovarian follicles of coho salmon [Oncorhynchus kisutch] in vitro","volume":"87","author":"KL Forsgren","year":"2012","journal-title":"Biol Reprod"},{"issue":"5","key":"pone.0311628.ref004","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/biolre\/iox124","article-title":"A teleost androgen promotes development of primary ovarian follicles in coho salmon and rapidly alters the ovarian transcriptome","volume":"97","author":"C Monson","year":"2017","journal-title":"Biol Reprod"},{"issue":"3\u20134","key":"pone.0311628.ref005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/15287390802539020","article-title":"Androgenic modulation of early growth of Atlantic cod [Gadus morhua L.] previtellogenic oocytes and zona radiata-related genes","volume":"72","author":"TM Kortner","year":"2009","journal-title":"J Toxicol Environ Health A"},{"key":"pone.0311628.ref006","first-page":"238","volume-title":"Regulation of development of primary and early secondary ovarian follicles of coho salmon [Oncorhynchus kisutch] by sex steroids (dissertation)","author":"University of Washington","year":"2010"},{"issue":"3","key":"pone.0311628.ref007","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1139\/z79-073","article-title":"The histochemistry and endocrine control of vitellogenesis in goldfish ovaries","volume":"57","author":"KH Khoo","year":"1979","journal-title":"Can J Zool"},{"issue":"1","key":"pone.0311628.ref008","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1095\/biolreprod.105.049494","article-title":"Previtellogenic oocyte growth in salmon: relationships among body growth, plasma insulin-like growth factor-1, estradiol-17beta, follicle-stimulating hormone and expression of ovarian genes for insulin-like growth factors, steroidogenic-acute regulatory p","volume":"75","author":"B Campbell","year":"2006","journal-title":"Biol Reprod"},{"issue":"6","key":"pone.0311628.ref009","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1095\/biolreprod.104.038190","article-title":"Zebrafish gonadotropins and their receptors: I. 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