{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:08:33Z","timestamp":1767841713460,"version":"3.49.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conseil departemental de la Guadeloupe"},{"name":"ARS de la Guadeloupe"},{"DOI":"10.13039\/100018683","name":"ARS Martinique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018683","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Saint-Martin"},{"name":"Saint-Barth\u00e9lemy","award":["2020\/DPAPH\/DRM"],"award-info":[{"award-number":["2020\/DPAPH\/DRM"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Antipsychotic prescriptions are frequent in nursing homes due to the challenging management of symptoms associated with Alzheimer\u2019s disease and related neurodegenerative disorders. This study aimed to assess the association between Health-related Quality Of Life (HrQOL) and antipsychotic use in nursing homes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This is a cross-sectional study of the KASEHPAD (Karukera Study of Ageing in Nursing Homes) study conducted in six nursing homes in Guadeloupe and Martinique (French West Indies). The EuroQol 5-dimensional questionnaire (EQ-5D) was used to measure HRQoL. Clinical characteristics and use of antipsychotic drugs of 194 older adults with both self-reported and proxy informant HrQOL index were extracted. Other outcomes measures included the frequency and severity of delusions, hallucinations and agitation using the reduced Neuropsychiatric Inventory Nursing Home (NPI-R) score, Activities of Daily Living (ADL) score and Mini-Mental State Examination (MMSE) score.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age of participants was 81.3 years and 63.6% had major cognitive impairment (MMSE score \u226418). The prevalence of delusions (39.7%), hallucinations (27.8%) and agitation (40.7%) was high. Antipsychotic medication was prescribed to 37.1% of the participants. The self-reported HrQOL Index of older adults was higher than the proxy HrQOL Index (0.54 \u00b1 0.43 versus 0.40 \u00b1 0.43) with a correlation coefficient of 0.63 (p&lt;0.001). The use of antipsychotic medication was associated with a higher self-reported HrQOL index, after controlling for the frequency (<jats:italic>\u03b2<\/jats:italic> = 0.144, p = 0.024) or severity (<jats:italic>\u03b2<\/jats:italic> = 0.159, p = 0.009) of delusions, hallucinations and agitation symptoms. Conversely, antipsychotic use was not associated with proxy HrQOL Index.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Despite the adverse effects of long-term use of antipsychotic drugs in older adults, it is associated with better-perceived HrQOL among nursing home residents. However, this association was not observed when HrQOL was assessed by proxy informants. This finding may explain the challenges in reducing the use of this therapeutic class in nursing homes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0311823","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T18:27:32Z","timestamp":1736274452000},"page":"e0311823","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between self-reported and proxy informant Health Quality of life of older adults with the use of antipsychotic drugs in nursing homes. A cross-sectional study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7797-241X","authenticated-orcid":true,"given":"Denis","family":"Boucaud-Maitre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fares","family":"Jaballah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-937X","authenticated-orcid":true,"given":"Luc","family":"Letenneur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Rinaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Dartigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustapha","family":"Dram\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Amieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maturin","family":"Tabu\u00e9-Teguo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"issue":"8","key":"pone.0311823.ref001","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1016\/S2666-7568(23)00131-9","article-title":"Antipsychotic drug prescribing in dementia: changes from the pandemic","volume":"4","author":"C Ballard","year":"2023","journal-title":"Lancet Healthy Longev"},{"issue":"11","key":"pone.0311823.ref002","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1017\/S1041610216001150","article-title":"Psychotropic drug prescriptions in Western European nursing homes","volume":"28","author":"SI Janus","year":"2016","journal-title":"Int Psychogeriatr"},{"issue":"12","key":"pone.0311823.ref003","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1111\/jgs.18555","article-title":"Antipsychotic use among older patients with dementia receiving home health care services: Prevalence, predictors, and outcomes","volume":"71","author":"J Wang","year":"2023","journal-title":"J Am Geriatr Soc"},{"key":"pone.0311823.ref004","first-page":"e076268","article-title":"Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study","volume":"385","author":"PLH Mok","year":"2024","journal-title":"BMJ"},{"key":"pone.0311823.ref005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.eurpsy.2016.11.013","article-title":"Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer\u2019s dementia","volume":"42","author":"RE Nielsen","year":"2017","journal-title":"Eur Psychiatry"},{"issue":"7","key":"pone.0311823.ref006","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jalz.2016.03.006","article-title":"Mortality risk in current and new antipsychotic Alzheimer\u2019s disease users: Large scale Japanese study","volume":"12","author":"H Arai","year":"2016","journal-title":"Alzheimers Dement"},{"key":"pone.0311823.ref007","doi-asserted-by":"crossref","first-page":"g6420","DOI":"10.1136\/bmj.g6420","article-title":"Don\u2019t use antipsychotics routinely to treat agitation and aggression in people with dementia","volume":"349","author":"A Corbett","year":"2014","journal-title":"BMJ"},{"issue":"12","key":"pone.0311823.ref008","first-page":"CD013304","article-title":"Antipsychotics for agitation and psychosis in people with Alzheimer\u2019s disease and vascular dementia","volume":"12","author":"V M\u00fchlbauer","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"pone.0311823.ref009","first-page":"qxad022","article-title":"Nursing Homes Underreport Antipsychotic Use but Overreport Diagnoses Qualifying for Appropriate Use","volume":"1","author":"AC Chen","year":"2023","journal-title":"Health Aff Sch"},{"key":"pone.0311823.ref010","unstructured":"US Department of health and Human services. 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