{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:22:53Z","timestamp":1747196573749,"version":"3.40.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Necrotizing enterocolitis is one of the most common, life-threatening, gastrointestinal disorders in neonates. The recovery time for neonates with NEC varies depending on disease severity, prompt diagnosis, and effective treatment. Therefore, this study was intended to assess the time to recover from necrotizing enterocolitis and its\u2019 predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar City, Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>An institution-based retrospective follow-up study design was employed. A sample of 361 medical records of neonates with necrotizing enterocolitis was selected using systematic random sampling. Diagnosis of NEC in this study required clinical, laboratory and radiographic findings. The survival function was described using Kaplan Meier survival curve and log-rank test. Bivariate and multivariate Cox-proportional hazard (Cox-PH) regression models were used for analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The median recovery time from necrotizing enterocolitis for neonates in the neonatal intensive care unit was 12 days. The multivariable Cox-PH model showed that neonates classified as Stage III NEC (AHR: 0.42, 95% CI = 0.23\u20130.77) and those exposed to perinatal asphyxia (AHR: 0.51, 95% CI: 0.35\u20130.74) had a negative impact on NEC recovery time. However, neonates with a birth weight of 1500-2499gm (AHR: 1.65, 95% CI: 1.05\u20132.58) and a platelet count greater than 150,000 (AHR: 1.75, 95% CI: 1.24\u20132.48) had a positive effect on NEC recovery time.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The recovery time for neonates in the neonatal intensive care unit with necrotizing enterocolitis was longer. Comorbidities and advanced stage of NEC were associated with prolonged recovery time from NEC. However, neonates with better platelet count and birth weight greater than 1500mg had shorter recovery time from NEC.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0311890","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:34:37Z","timestamp":1729618477000},"page":"e0311890","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to recovery from necrotizing enterocolitis and its predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar, Ethiopia: A retrospective follow up study, 2022"],"prefix":"10.1371","volume":"19","author":[{"given":"Birtukan Ayana","family":"Tefera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurahman Mohammed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-5227","authenticated-orcid":true,"given":"Sisay Shewasinad","family":"Yehualashet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"pone.0311890.ref001","article-title":"Necrotizing enterocolitis","volume":"340","author":"NEC IBNE","year":"2018","journal-title":"MANUAL OF NEONATAL CARE"},{"issue":"2","key":"pone.0311890.ref002","doi-asserted-by":"crossref","first-page":"F182","DOI":"10.1136\/archdischild-2017-313880","article-title":"Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review","volume":"103","author":"C Battersby","year":"2018","journal-title":"Archives of disease in childhood Fetal and neonatal edition"},{"issue":"1","key":"pone.0311890.ref003","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clp.2012.12.012","article-title":"A clinical perspective of necrotizing enterocolitis: past, present, and future","volume":"40","author":"R Sharma","year":"2013","journal-title":"Clin Perinatol"},{"key":"pone.0311890.ref004","doi-asserted-by":"crossref","first-page":"P7","DOI":"10.1016\/j.jpeds.2019.12.035","article-title":"Necrotizing Enterocolitis: Updates on Morbidity and Mortality Outcomes","volume":"220","author":"M Colleen Flahive","year":"2020","journal-title":"The Journal of Pediatrics January 16"},{"key":"pone.0311890.ref005","article-title":"Muhammad Aslam, MD","author":"Author: Shelley C Springer J, MD, MSc, MBA, FAAP; Chief Editor","year":"2017","journal-title":"Necrotizing Enterocolitis"},{"key":"pone.0311890.ref006","first-page":"2333794x211019695","article-title":"The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia","volume":"8","author":"SM Mekonnen","year":"2021","journal-title":"A Cross-sectional Study"},{"issue":"1","key":"pone.0311890.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-020-02231-5","article-title":"Global incidence of necrotizing enterocolitis: a systematic review and meta-analysis","volume":"20","author":"A Alsaied","year":"2020","journal-title":"BMC pediatrics"},{"issue":"12","key":"pone.0311890.ref008","first-page":"451","article-title":"Survival Status and Predictors of Mortality Among Low-Birth-Weight Neonates Admitted to the Neonatal Intensive Care Unit at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar","volume":"2021","author":"TA Woelile","year":"2020","journal-title":"Ethiopia"},{"key":"pone.0311890.ref009","article-title":"Necrotizing enterocolitis","author":"SJ Kuik","year":"2020","journal-title":"Survivalintestinal recovery, and neurodevelopment"},{"issue":"2","key":"pone.0311890.ref010","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/ANC.0b013e31824cee94","article-title":"Necrotizing enterocolitis risk: state of the science.","volume":"12","author":"SM Gephart","year":"2012","journal-title":"Advances in neonatal care: official journal of the National Association of Neonatal Nurses"},{"key":"pone.0311890.ref011","doi-asserted-by":"crossref","first-page":"105091","DOI":"10.1016\/j.earlhumdev.2020.105091","article-title":"Time to full enteral feeding after necrotizing enterocolitis in preterm-born children is related to neurodevelopment at 2\u20133 years of age","volume":"147","author":"SJ Kuik","year":"2020","journal-title":"Early Hum Dev"},{"key":"pone.0311890.ref012","article-title":"Historical Perspectives: Necrotizing Enterocolitis:","author":"K. 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