{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:56Z","timestamp":1792670876861,"version":"4.5.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Currently, there is an irrational use of drugs in the treatment of hypoproteinemia. This study evaluates the value of 12 injections to provide a basis for drug selection for the treatment of hypoproteinemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The content of the first restrictive amino acid, the comprehensive quality of the total essential amino acid, and the closeness to the whole egg protein or FAO\/WHO model were evaluated to compare their value in the amino acid synthesis of human serum albumin. A comparison was made between the matching degree of HA and therapeutic amino acids with the human plasma amino acid profile. Furthermore, the value and safety of synthetic human serum albumin were compared.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The lowest synthetic value of human serum albumin was 18AA-V, and the highest was 18AA-II. The CS values of HA, 18AA-V, 18AA-II, 18AA-Ip, 18AA-II<jats:sub>p<\/jats:sub>, and 19AA-I<jats:sub>p<\/jats:sub> were 0.18, 0.58, 0.78, 0.55, 0.54, and 0.59, respectively. The similarity to egg protein was 0.81, 0.92, 0.94, 1.00, 1.18, and 1.18, respectively. The proximity values to FAO\/WHO standards were 0.81, 0.85, 0.90, 1.36, 1.54, and 1.54, respectively. The changes in 3AA and the amino acid profile were matched when liver function was abnormal. When the renal function was abnormal, 9AA was matched. During trauma, 18AA-VII was matched. The amino acid profile of HA did not correspond.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Patients with normal liver and kidney function should choose compound balanced amino acid injection, while patients with abnormalities should choose 3AA. Patients with renal dysfunction should choose 9AA. Trauma patients should choose 18AA-VII.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0311949","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T17:31:29Z","timestamp":1729531889000},"page":"e0311949","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is human albumin injection the best choice to treat hypoalbuminemia?"],"prefix":"10.1371","volume":"19","author":[{"given":"Yingqin","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3461-5594","authenticated-orcid":true,"given":"Hailing","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"issue":"18","key":"pone.0311949.ref001","first-page":"205","article-title":"Human albumin: old, new, and emerging applications","volume":"10","author":"J Rozga","year":"2013","journal-title":"Ann Transplant"},{"issue":"13","key":"pone.0311949.ref002","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/ajhp\/60.13.1330","article-title":"Evaluation of the appropriate use of albumin in adult and pediatric patients.","volume":"60","author":"M Tanzi","year":"2003","journal-title":"Am J Health Syst Pharm.Jul 1"},{"issue":"12","key":"pone.0311949.ref003","first-page":"722","article-title":"Albumin Usage in Iran[J].","volume":"22","author":"A Rezapour","year":"2019","journal-title":"Arch Iran Med"},{"issue":"3","key":"pone.0311949.ref004","doi-asserted-by":"crossref","first-page":"300060520987731","DOI":"10.1177\/0300060520987731","article-title":"Single-center analysis of the inappropriate use of human albumin and nutritional support in hospitalized patients with hypoproteinemia in China","volume":"49","author":"J Zhang","year":"2021","journal-title":"J Int Med Res"},{"issue":"2","key":"pone.0311949.ref005","first-page":"228","article-title":"Research progress of senile hypoproteinemia.","volume":"39","author":"J Meng","year":"2020","journal-title":"Chinese Journal of Geriatrics"},{"issue":"1","key":"pone.0311949.ref006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/MCO.0b013e32834de431","article-title":"The importance of amino acids as independent metabolites, signalling molecules and as building blocks for protein.","volume":"15","author":"J Brosnan","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care."},{"issue":"1","key":"pone.0311949.ref007","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(75)80242-0","article-title":"Complete amino acid sequence of human serum albumin","volume":"58","author":"B Meloun","year":"1975","journal-title":"FEBS Lett"},{"key":"pone.0311949.ref008","doi-asserted-by":"crossref","first-page":"880256","DOI":"10.3389\/fnut.2022.880256","article-title":"Comprehensive Evaluation of Clinical Application of Balanced Compound Amino Acid Injection.","volume":"9","author":"Y Shi","year":"2022","journal-title":"Front Nutr"},{"issue":"8","key":"pone.0311949.ref009","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.4315\/0362-028X-67.8.1806","article-title":"Sulfites\u2014a food and drug administration review of recalls and reported adverse events","volume":"67","author":"B Timbo","year":"2004","journal-title":"J Food Prot"},{"issue":"5","key":"pone.0311949.ref010","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/fsn3.1533","article-title":"Enzymatic hydrolysis pretreatment for enhancing the protein solubility and physicochemical quality of Cordyceps militaris chicken soup.","volume":"8","author":"H Dong","year":"2020","journal-title":"Food Sci Nutr."},{"key":"pone.0311949.ref011","first-page":"1","article-title":"Report of a joint FAO\/WHO\/UNU Expert Consultation","volume":"724","author":"Energy and protein requirements","year":"1985","journal-title":"World Health Organ Tech Rep Ser"},{"key":"pone.0311949.ref012","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.foodchem.2014.11.083","article-title":"Chemical properties in fruits of mulberry species from the Xinjiang province of China","volume":"174","author":"Y Jiang","year":"2015","journal-title":"Food Chem"},{"issue":"Pt A","key":"pone.0311949.ref013","article-title":"Fabrication, properties and applications of soy-protein-based materials: A review","volume":"120","author":"H Tian","year":"2018","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"pone.0311949.ref014","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/fsn3.1533","article-title":"Enzymatic hydrolysis pretreatment for enhancing the protein solubility and physicochemical quality of Cordyceps militaris chicken soup.","volume":"8","author":"H Dong","year":"2020","journal-title":"Food Sci Nutr"},{"issue":"5","key":"pone.0311949.ref015","first-page":"57","article-title":"Clinical rational use of compound amino acid injection.","volume":"23","author":"H Li","year":"2014","journal-title":"China Pharmaceutical"},{"issue":"6","key":"pone.0311949.ref016","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.20720","article-title":"Albumin: biochemical properties and therapeutic potential","volume":"41","author":"GJ Quinlan","year":"2005","journal-title":"Hepatology"},{"issue":"02","key":"pone.0311949.ref017","first-page":"183","article-title":"Expert consensus on clinical application of compound amino acid injection","volume":"6","author":"C Gao","year":"2019","journal-title":"Electronic Journal of Cancer Metabolism and Nutrition"},{"issue":"4","key":"pone.0311949.ref018","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archinte.1995.00430040041005","article-title":"A paradigm for consensus. The University Hospital Consortium guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions","volume":"155","author":"LC Vermeulen","year":"1995","journal-title":"Arch Intern Med"},{"issue":"3","key":"pone.0311949.ref019","first-page":"216","article-title":"Recommendations for the use of albumin and immunoglobulins.","volume":"7","author":"Italian Society of Transfusion Medicine and Immunohaematology (SIMTI).","year":"2009","journal-title":"Blood Transfus"},{"issue":"06","key":"pone.0311949.ref020","first-page":"581","article-title":"Clinical application investigation and rationality oh human serum albumin","volume":"23","author":"Y Hang","year":"2015","journal-title":"Pharmaceutical and Clinical Research"},{"key":"pone.0311949.ref021","volume-title":"Blue book on the development and clinical application of blood products in China.","author":"Z. G. Zhao","year":"2022"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0311949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T17:31:37Z","timestamp":1729531897000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0311949"}},"subtitle":[],"editor":[{"given":"Ogochukwu Chinedum","family":"Okoye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0311949","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}