{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:22:31Z","timestamp":1792891351263,"version":"4.5.0"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Aim<\/jats:title>\n<jats:p>Successful acute migraine treatment potentially prevents emergency room (ER) consultations but requires that the diagnosis of migraine was given earlier. The aim of this study is to quantify the problem of missed migraine diagnosis prior to ER visits.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Inclusion criterion for this single-center prospective study was the presentation at the ER for acute headache. Patients with acute migraine attacks were assessed for previous migraine attacks, and whether they were given a diagnosis of migraine in the past.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of 137 patients with migraine diagnosis at discharge, 108 (79%) had previous headache attacks fulfilling the criteria for migraine according to The International Classification of Headache Disorders 3rd edition (ICHD-3). Of those, 54 (50%) received the diagnosis for the first time.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Half of the migraine patients (50%) presenting in the ER for headache could have been diagnosed earlier. This highlights the need for better detection and treatment of migraine by pre-hospital healthcare providers, as earlier diagnosis and specific acute treatment could have prevented the ER visit.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0312106","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:30:07Z","timestamp":1729272607000},"page":"e0312106","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine\u2013A prospective observational study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-9121","authenticated-orcid":true,"given":"Hristina","family":"Drangova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kofmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-7882","authenticated-orcid":true,"given":"Mattia","family":"Branca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gloor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis","family":"Exadaktylos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Schankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"11","key":"pone.0312106.ref001","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","year":"2018","journal-title":"Lancet Neurol"},{"issue":"1","key":"pone.0312106.ref002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/acem.13062","article-title":"Acute Headache Presentations to the Emergency Department: A Statewide Cross-sectional Study.","volume":"24","author":"KH Chu","year":"2017","journal-title":"Acad Emerg Med."},{"issue":"7","key":"pone.0312106.ref003","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10072-015-2148-7","article-title":"Management of headache disorders in the Emergency Department setting.","volume":"36","author":"E Pari","year":"2015","journal-title":"Neurol Sci."},{"issue":"6","key":"pone.0312106.ref004","first-page":"597","article-title":"[Headache in the emergency department].","volume":"88","author":"CJ Schankin","year":"2017","journal-title":"Nervenarzt."},{"issue":"3","key":"pone.0312106.ref005","first-page":"281","article-title":"Analysis of headache management in emergency room.","volume":"52","author":"VV Cvetkovi\u0107","year":"2013","journal-title":"Acta Clin Croat"},{"issue":"6","key":"pone.0312106.ref006","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1468-2982.2006.01093.x","article-title":"Headache in United States emergency departments: demographics, work-up and frequency of pathological diagnoses.","volume":"26","author":"JN Goldstein","year":"2006","journal-title":"Cephalalgia."},{"key":"pone.0312106.ref007","doi-asserted-by":"crossref","first-page":"d5076","DOI":"10.1136\/bmj.d5076","article-title":"Magnitude, impact, and stability of primary headache subtypes: 30 year prospective Swiss cohort study","volume":"343","author":"KR Merikangas","year":"2011","journal-title":"BMJ"},{"issue":"1","key":"pone.0312106.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition.","volume":"38","author":"J. Olesen","year":"2018","journal-title":"Cephalalgia"},{"issue":"4","key":"pone.0312106.ref009","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10194-007-0395-6","article-title":"The effects of a sensitisation campaign on unrecognised migraine: the Casilino study","volume":"8","author":"V Di Piero","year":"2007","journal-title":"J Headache Pain"},{"issue":"8","key":"pone.0312106.ref010","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1526-4610.2007.00846.x","article-title":"Less Is Not More: Underutilization of Headache Medications in a University Hospital Emergency Department.","volume":"47","author":"MX Gupta","year":"2007","journal-title":"Headache: The Journal of Head and Face Pain."},{"issue":"4","key":"pone.0312106.ref011","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ncl.2019.06.001","article-title":"Migraine: Epidemiology, Burden, and Comorbidity.","volume":"37","author":"RC Burch","year":"2019","journal-title":"Neurol Clin"},{"issue":"2","key":"pone.0312106.ref012","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0038-1646946","article-title":"The Global Burden of Headache.","volume":"38","author":"D Saylor","year":"2018","journal-title":"Semin Neurol."},{"key":"pone.0312106.ref013","unstructured":"Drangova H, Kofmel N, Branca M, Gloor D, Lehmann B, Exadaktylos A, et al. Timely diagnosis of migraine\u2013A prospective observational study assessing the potential to prevent unnecessary emergency department visits for headache. International Headache Congress; 8\u201312 September; virtual: SAGE Publications; 2021. p. 130."},{"key":"pone.0312106.ref014","first-page":"442","article-title":"The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine.","author":"H Drangova","year":"2021","journal-title":"European Academy of Neurology (EAN) Congress 2021; 19.06.2021; virtual: European Journal of Neurology"},{"issue":"3","key":"pone.0312106.ref015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/0333102415583982","article-title":"Improving the detection of chronic migraine: Development and validation of Identify Chronic Migraine (ID-CM).","volume":"36","author":"RB Lipton","year":"2016","journal-title":"Cephalalgia."},{"issue":"1","key":"pone.0312106.ref016","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1080\/07853890.2021.1995626","article-title":"A rational approach to migraine diagnosis and management in primary care.","volume":"53","author":"VT Martin","year":"2021","journal-title":"Ann Med."},{"issue":"1","key":"pone.0312106.ref017","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s10194-018-0864-0","article-title":"Use and overuse of triptans in Austria\u2014a survey based on nationwide healthcare claims data","volume":"19","author":"K Zebenholzer","year":"2018","journal-title":"J Headache Pain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:30:13Z","timestamp":1729272613000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312106"}},"subtitle":[],"editor":[{"given":"Ryan G.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0312106","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}