{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:44:06Z","timestamp":1792802646909,"version":"4.5.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Scientific Research Foundation of Hunan Provincial Education Department","award":["No. 20A434"],"award-info":[{"award-number":["No. 20A434"]}],"id":[{"id":"https:\/\/ror.org\/026meb765","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Natural Science Foundation of Guangxi in China","award":["No. 2020GXNSFAA297097"],"award-info":[{"award-number":["No. 2020GXNSFAA297097"]}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province, China","doi-asserted-by":"crossref","award":["No. 2020JJ5511"],"award-info":[{"award-number":["No. 2020JJ5511"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province, China","doi-asserted-by":"crossref","award":["No. 2024JJ9373"],"award-info":[{"award-number":["No. 2024JJ9373"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["No. 22B0406"],"award-info":[{"award-number":["No. 22B0406"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["No. W20243058"],"award-info":[{"award-number":["No. W20243058"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Hengyang City science and technology innovation plan","award":["No. 202330046470"],"award-info":[{"award-number":["No. 202330046470"]}]},{"name":"the Hunan Province Innovation and Entrepreneurship Training Program for College Students","award":["No. S202310555229, S202310555214 and D202305162026050688"],"award-info":[{"award-number":["No. S202310555229, S202310555214 and D202305162026050688"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Patients with Polycystic ovary syndrome (PCOS) have chronic low-grade ovarian inflammation. Inflammation can cause telomere dysfunction, and telomere and telomerase complex are also involved in regulating inflammation. However, the specific mechanisms of inflammatory signaling feedback and telomere-telomerase mutual regulation remain to be discovered. This study elucidates the role of Nuclear factor kappa-B (NF-\u03baB)-Telomerase reverse transcriptase (TERT) feedback in PCOS granulosa cell apoptosis. Using letrozole and a high-fat diet, a PCOS rat model was established, along with a Lipopolysaccharide (LPS) -treated KGN cell inflammation model was established. NF-\u03baB and TERT inhibitors (BAY 11\u20137082 and BIBR1532) were then administered to LPS-induced KGN cells. PCOS rats displayed disrupted estrous cycles, increased weight, elevated serum testosterone, cystic follicles, granulosa cell layer thinning, and reduced corpora lutea count (\n                    <jats:italic>P<\/jats:italic>\n                    are all less than 0.05). In PCOS rat ovaries, NF-\u03baB, Interleukin-6 (IL-6), Tumor Necrosis Factor \u03b1 (TNF-\u03b1), TERT, Bax, and Caspase-3 exhibited notable upregulation, while Bcl-2 decreased, with telomere elongation (\n                    <jats:italic>P<\/jats:italic>\n                    are all less than 0.05). There were significant correlations among NF-\u03baB-related inflammatory factors, TERT and apoptotic factors, and they were positively correlated with Bax and Caspase-3, and negatively correlated with Bcl-2 (\n                    <jats:italic>P<\/jats:italic>\n                    are all less than 0.05). LPS-treated KGN cells demonstrated increased expression of inflammatory and pro-apoptotic factors, later restored post-treatment with NF-\u03baB and TERT inhibitors (\n                    <jats:italic>P<\/jats:italic>\n                    are all less than 0.05). In conclusion, TERT may induce granulosa cell apoptosis by participating in the regulation of the NF-\u03baB signaling pathway, thereby mediating the chronic inflammatory response of PCOS through downstream inflammatory factors IL-6 and TNF-\u03b1.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0312115","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T13:28:48Z","timestamp":1729862928000},"page":"e0312115","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["The mechanism of NF-\u03baB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats"],"prefix":"10.1371","volume":"19","author":[{"given":"Haoxuan","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zecheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2309-5882","authenticated-orcid":true,"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"issue":"5","key":"pone.0312115.ref001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.","volume":"14","author":"HF Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol."},{"issue":"9","key":"pone.0312115.ref002","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"AE Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"pone.0312115.ref003","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).","volume":"19","author":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum Reprod"},{"issue":"1","key":"pone.0312115.ref004","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/jrms.JRMS_804_16","article-title":"The glucose metabolism disorder and dyslipidemia among girls with different phenotype polycystic ovary syndrome","volume":"24","author":"M Akbarzadeh","year":"2019","journal-title":"J Res Med Sci"},{"issue":"S2","key":"pone.0312115.ref005","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.ijo.0803730","article-title":"Role of obesity and adiposity in polycystic ovary syndrome.","volume":"31","author":"E. 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