{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:03:30Z","timestamp":1788545010954,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2024\/01\/78904"],"award-info":[{"award-number":["PSAU\/2024\/01\/78904"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The Thyroid Imaging Reporting and Data System (TI-RADS) is an essential tool for assessing thyroid nodules, primarily used by radiologists. This study aimed to compare the agreement of TI-RADS scores between sonographers and radiologists and to assess the diagnostic performance of these scores against histological findings in suspicious thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective analysis, 168 patients with suspicious thyroid nodules classified as TR3 and above by the radiologists were included. Both sonographers and radiologists independently assigned the American College of Radiologists (ACR) TI-RADS scores, which were then compared for inter-reader agreement using Cohen\u2019s Kappa statistic. The scores were also evaluated for diagnostic performance against histological results based on the Bethesda system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study revealed a moderate overall agreement between sonographers and radiologists in TI-RADS scoring (\u03ba = 0.504; 95% CI: 0.409\u20130.599), with poor agreement noted specifically for nodule margin scores (\u03ba = 0.102; 95% CI: -1.430\u20130.301). In terms of diagnostic performance against histological outcomes, sonographers\u2019 TI-RADS scores showed a sensitivity of 100% and a specificity of 44.6%, while radiologists\u2019 scores showed a sensitivity of 100% but a lower specificity of 29.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate moderate agreement in TI-RADS scoring between sonographers and radiologists, with reproducibility challenges especially in scoring nodule margins. The marginally superior diagnostic performance of sonographers\u2019 scores suggests potential efficiency benefits in involving sonographers in preliminary assessments. Future research should aim to encompass a wider range of TI-RADS categories and focus on minimizing scoring variability to enhance the system\u2019s clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0312121","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T13:32:21Z","timestamp":1728653541000},"page":"e0312121","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluating diagnostic accuracy and agreement of TI-RADS scoring in thyroid nodules: A comparative analysis between sonographers and radiologists"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-7248","authenticated-orcid":true,"given":"Abdulrahman M.","family":"Alfuraih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M.","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanoud K.","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basmah F.","family":"Alrashied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya M.","family":"Mashhor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed J.","family":"Alsaadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"pone.0312121.ref001","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03346587","article-title":"American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations","volume":"33","author":"H Gharib","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"pone.0312121.ref002","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMcp031436","article-title":"The thyroid nodule","volume":"351","author":"L. 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A prospective double-blind study comparing the accuracy of radiologist and radiographer","volume":"55","author":"A Leslie","year":"2000","journal-title":"Clin Radiol"},{"key":"pone.0312121.ref016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1078-8174(03)00004-X","article-title":"Can sonographers offer an accurate upper abdominal ultrasound service in a district general hospital?","volume":"9","author":"NA Dongola","year":"2003","journal-title":"Radiography"},{"key":"pone.0312121.ref017","first-page":"71","article-title":"Advanced-practice sonography in obstetrics and gynecology: a pilot study investigating the efficacy of the ultrasound practitioner","volume":"28","author":"WH Persutte","year":"1999","journal-title":"J Allied Health"},{"key":"pone.0312121.ref018","first-page":"36","article-title":"Musculoskeletal ultrasound: audit of sonographer reporting","volume":"18","author":"SJ 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predicting the type of thyroid lesions: a meta-analysis of prospective studies","volume":"124","author":"K Wolinski","year":"2014","journal-title":"Pol Arch Med Wewn"},{"key":"pone.0312121.ref028","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2214\/AJR.17.18822","article-title":"Comparison of performance characteristics of american college of radiology TI-RADS, Korean Society of thyroid radiology TIRADS, and American Thyroid Association guidelines","volume":"210","author":"WD Middleton","year":"2018","journal-title":"American Journal of Roentgenology."},{"key":"pone.0312121.ref029","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1089\/thy.2014.0353","article-title":"Thyroid ultrasound features and risk of carcinoma: a systematic review and meta-analysis of observational studies","volume":"25","author":"LR Remonti","year":"2015","journal-title":"Thyroid"},{"key":"pone.0312121.ref030","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1148\/radiol.2015150056","article-title":"Malignancy risk stratification of thyroid nodules: comparison between the thyroid imaging reporting and data system and the 2014 American Thyroid Association management guidelines","volume":"278","author":"JH Yoon","year":"2016","journal-title":"Radiology."},{"key":"pone.0312121.ref031","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/thy.2008.0354","article-title":"Interobserver and intraobserver variations in ultrasound assessment of thyroid nodules","volume":"20","author":"SH Choi","year":"2010","journal-title":"Thyroid"},{"key":"pone.0312121.ref032","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiol.2017171240","article-title":"Thyroid Imaging Reporting and Data System (TI-RADS): A User\u2019s Guide.","volume":"287","author":"FN 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Carlos","year":"2024","journal-title":"Endocrine"},{"key":"pone.0312121.ref039","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.ultrasmedbio.2020.04.019","article-title":"Using the American College of Radiology Thyroid Imaging Reporting and Data System at the point of care: sonographer performance and interobserver variability","volume":"46","author":"B Wildman-Tobriner","year":"2020","journal-title":"Ultrasound Med Biol"},{"key":"pone.0312121.ref040","first-page":"6","article-title":"A prospective study to evaluate the reliability of thyroid imaging reporting and data system in differentiation between benign and malignant thyroid lesions","author":"MNS Srinivas","year":"2016","journal-title":"J Clin Imaging Sci"},{"key":"pone.0312121.ref041","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jacr.2015.07.011","article-title":"Thyroid Ultrasound Reporting Lexicon: White Paper of the ACR Thyroid Imaging, Reporting and Data System (TIRADS) 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