{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:01:14Z","timestamp":1777935674662,"version":"3.51.4"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONAHCyT","doi-asserted-by":"crossref","award":["A3-S-39996"],"award-info":[{"award-number":["A3-S-39996"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"CONAHCYT","doi-asserted-by":"crossref","award":["1045788"],"award-info":[{"award-number":["1045788"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In systemic lupus erythematosus, immune complexes deposited in the kidney vasculature represent a potent inflammatory trigger with a high potential to progress to glomerulonephritis and organ failure. These immune complexes can be recognized by multiple effector cells via complement and Fc\u03b3 receptors. The transcriptome of CD16-bearing NK cells has been documented in kidneys from patients with SLE. In this study, we show that NK cells accumulate in the kidney in response to immune complex deposition and modulate the behavior of local T cells. Depletion of NK cells transiently ameliorated disease, suggesting NK cells may play a role in lupus nephritis and other immune complex-mediated conditions.<\/jats:p>","DOI":"10.1371\/journal.pone.0312141","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T18:47:58Z","timestamp":1732214878000},"page":"e0312141","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immune complex deposition promotes NK cell accumulation in the kidney"],"prefix":"10.1371","volume":"19","author":[{"given":"Abigail","family":"De la Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Garc\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Larios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-9248","authenticated-orcid":true,"given":"Iris K.","family":"Madera-Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Crisp\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-4515","authenticated-orcid":true,"given":"Florencia","family":"Rosetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"pone.0312141.ref001","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus, Mechanisms of disease review article","volume":"365","author":"GC Tsokos","year":"2011","journal-title":"N Engl J Med"},{"key":"pone.0312141.ref002","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/rheumatology\/kev311","article-title":"The frequency and outcome of lupus nephritis: results from an international inception cohort study","volume":"55","author":"JG Hanly","year":"2016","journal-title":"Rheumatology (Oxford)."},{"key":"pone.0312141.ref003","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/art.39594","article-title":"Risk of End-Stage Renal Disease in Patients With Lupus Nephritis, 1971\u20132015: A Systematic Review and Bayesian Meta-Analysis.","volume":"68","author":"MG Tektonidou","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"pone.0312141.ref004","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2008.04.013","article-title":"Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases","volume":"28","author":"N Tsuboi","year":"2008","journal-title":"Immunity"},{"key":"pone.0312141.ref005","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1126\/science.279.5353.1052","article-title":"Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis","volume":"279","author":"R Clynes","year":"1998","journal-title":"Science"},{"key":"pone.0312141.ref006","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1046\/j.1523-1755.2001.00017.x","article-title":"Proteinuria and tubulointerstitial lesions in lupus nephritis","volume":"60","author":"GS Hill","year":"2001","journal-title":"Kidney Int"},{"key":"pone.0312141.ref007","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.kint.2022.05.033","article-title":"Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis","volume":"102","author":"S V. 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