{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:25:48Z","timestamp":1779139548037,"version":"3.51.4"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2021ZD01006"],"award-info":[{"award-number":["2021ZD01006"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen Municipality","doi-asserted-by":"publisher","award":["3502Z20227139"],"award-info":[{"award-number":["3502Z20227139"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The purpose of this study was to assess associations between iron homeostasis-related gene polymorphisms and gestational diabetes mellitus (GDM), adverse pregnancy outcomes, and neonatal outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In total, 138 patients with GDM and 74 normal pregnancy controls were recruited. Time-of-flight mass spectrometry was used to genotype single-nucleotide polymorphisms (<jats:italic>H63D<\/jats:italic> rs1799945, <jats:italic>TMPRSS6<\/jats:italic> rs855791, <jats:italic>GDF15<\/jats:italic> rs1059369, rs4808793, <jats:italic>BMP2<\/jats:italic> rs173107, <jats:italic>C282Y<\/jats:italic> rs3811647, rs1800562, rs269853, <jats:italic>TF<\/jats:italic> rs8177240, <jats:italic>TFR2<\/jats:italic> rs7385804, <jats:italic>FADS2<\/jats:italic> rs174577, and <jats:italic>CUBN<\/jats:italic> rs10904850) in 12 candidate genes related to iron homeostasis. Adverse pregnancy outcomes and neonatal health data were collected. Differences in genotype distributions and allele frequencies between patients and controls as well as their correlations with clinical factors were assessed. Additionally, associations between genotype, haemoglobin levels, and ferritin levels were evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Pregnant women carrying the <jats:italic>GDF15<\/jats:italic> rs4808793 allele (C) or <jats:italic>TMPRSS6<\/jats:italic> rs855791 homozygous mutation (GG) had a significantly higher risk of GDM than that in the control group (p &lt; 0.05). In patients with GDM, the <jats:italic>BMP2<\/jats:italic> rs173107 heterozygous mutation (AC) was associated with significantly higher haemoglobin levels in late pregnancy compared with those for wild-type (AA) <jats:italic>BMP2<\/jats:italic> (p &lt; 0.05). Furthermore, in patients with GDM, the <jats:italic>FADS2<\/jats:italic> rs174577 heterozygous mutation (AC) was associated with a significantly reduced risk of preterm birth (p &lt; 0.05), the <jats:italic>H63D<\/jats:italic> rs1799945 heterozygous mutation (CG) was associated with a significantly increased risk of adverse neonatal outcomes (p &lt; 0.05), <jats:italic>TFR2<\/jats:italic> rs7385804 was associated a significantly reduced probability of caesarean section (p &lt; 0.05), and the G mutation in <jats:italic>TMPRSS6<\/jats:italic> rs855791 was related to a significantly increased probability of caesarean section (p &lt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These results suggest that polymorphisms in genes related to iron metabolism could potentially impact pregnancy and neonatal outcomes in patients with GDM. Large-scale studies are needed to further clarify the relationship between these polymorphisms and susceptibility to GDM.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0312180","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T18:34:17Z","timestamp":1734028457000},"page":"e0312180","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of iron homeostasis-related gene polymorphisms with pregnancy and neonatal outcomes in patients with gestational diabetes 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