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Motivated by the ambition to understand the constraints under which PRs function, in this study we have drawn together diverse physiological and anatomical data in order to generate estimates of the rates of ATP production per mm<jats:sup>2<\/jats:sup> of retinal surface area. With the predictions of metabolic demand in the companion paper, we seek to develop an integrated energy budget for the outer retina. It is known that rod PR number and the extent of the choriocapillaris (CC) vascular network that supports PRs both decline with age. To set the outer retina energy budget in the context of aging we demonstrate how, at different eccentricities, decline CC density is more than matched by rod loss in a way that tends to preserve nutrient exchange per rod. Together these finds provide an integrated framework for the study of outer retinal metabolism and how it might change with age.<\/jats:p>","DOI":"10.1371\/journal.pone.0312260","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T18:56:26Z","timestamp":1735671386000},"page":"e0312260","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cEnergetics of the outer retina I: Estimates of nutrient exchange and ATP generation\u201d"],"prefix":"10.1371","volume":"19","author":[{"given":"Stella","family":"Prins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J. 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