{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:45Z","timestamp":1792678065930,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX0082"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX0082"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX0567"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0567"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX1093"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX1093"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and aims<\/jats:title>\n<jats:p>Cancer and its treatments may cause neurocognitive impairments in preschool children, but there is limited research on the neurocognitive outcomes of this population. This study, which assessed the neurocognitive function of preschool children with cancer and analyzed various influencing factors of neurocognitive functioning, is of significant importance. We aimed to investigate neurocognitive function and related risk factors in preschool children with cancer to inform preventive and intervention strategies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>From September 2023 to May 2024, we recruited 100 preschool children with cancer. The Chinese version of the Ages &amp; Stages Questionnaires, the Spence Preschool Anxiety Scale Chinese Version, and the Sleep Disturbance Scale for Children were used to collected data. Binary logistic stepwise regression analysis was used to explore the influencing factors of neurocognitive function in preschool children with cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>49% of the preschool children with cancer had abnormalities in at least one neurocognitive dimension. The majority of children had abnormalities in gross motor dimension, accounting for 30%, which was related to age and frequency of participation in neurocognitive activities. Communication dimension was related to father\u2019s education level, dietary habit, and frequency of participation in activities. Fine motor dimension was associated with age, sex, and father\u2019s education level. Problem-solving dimension was associated with age and dietary habit. Personal-social dimension was related to age and radiotherapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Nearly half of preschool children with cancer experienced neurocognitive impairment. The Chinese version of the Ages &amp; Stages Questionnaires is a simple and effective tool for screening children with possible neurocognitive impairment. It was found that children\u2019s neurocognitive function was significantly influenced by family environment, dietary habit, cognitive activities, and cancer treatment. Therefore, it is recommended to strengthen family and social support, and to formulate personalized intervention such as cognitive therapy and dietary adjustment based on children\u2019s age and family background, which are important for promoting neurocognitive recovery.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0312536","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T18:32:39Z","timestamp":1731349959000},"page":"e0312536","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Current investigation of neurocognitive functioning in preschool children with cancer: A cross-sectional study from western China"],"prefix":"10.1371","volume":"19","author":[{"given":"Zefang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-080X","authenticated-orcid":true,"given":"Lin","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"issue":"6","key":"pone.0312536.ref001","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International incidence of childhood cancer, 2001\u201310: a population-based registry study.","volume":"18","author":"E Steliarova-Foucher","year":"2017","journal-title":"LANCET 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CANCER"},{"issue":"7","key":"pone.0312536.ref022","first-page":"492","article-title":"[Studies of the norm and psychometric properties of Ages and Stages Questionnaires in Shanghai children].","volume":"48","author":"XY Bian","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"pone.0312536.ref023","article-title":"Psychometric Analysis of Preschool Anxiety Scale in Chinese Culture.","author":"W Mei-Fang","year":"2009","journal-title":"Chinese Journal of Clinical Psychology"},{"key":"pone.0312536.ref024","first-page":"S108","article-title":"Neurocogntive outcomes in survivors of childhood acutelymphoblastic leukemia","volume":"65","author":"V Cr","year":"2018","journal-title":"Pediatr. Blood CancerPediatric Blood and Cancer"},{"issue":"5","key":"pone.0312536.ref025","first-page":"1074","article-title":"Increased health-related quality of life impairments of male and female survivors of childhood cancer: DCCSS LATER 2 psycho-oncology study.","volume":"128","author":"M van Gorp","year":"2022","journal-title":"CANCER-AM CANCER SOC."},{"issue":"8","key":"pone.0312536.ref026","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/pon.5456","article-title":"Self-reported cognitive outcomes among adolescent and young adult patients with noncentral nervous system cancers.","volume":"29","author":"CJ Tan","year":"2020","journal-title":"PSYCHO-ONCOLOGY"},{"issue":"3\u20134","key":"pone.0312536.ref027","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11682-010-9104-1","article-title":"Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia","volume":"4","author":"SR Kesler","year":"2010","journal-title":"BRAIN IMAGING BEHAV"},{"issue":"8","key":"pone.0312536.ref028","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081939","article-title":"Age-and intravenous methotrexate-associated leukoencephalopathy and its neurological impact in pediatric patients with lymphoblastic leukemia","volume":"13","author":"I Rijmenams","year":"2021","journal-title":"Cancers"},{"issue":"4","key":"pone.0312536.ref029","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/pon.4186","article-title":"Intellectual development of childhood ALL patients: a multicenter longitudinal study.","volume":"26","author":"C Sleurs","year":"2017","journal-title":"PSYCHO-ONCOLOGY"},{"issue":"12","key":"pone.0312536.ref030","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jnci\/djt089","article-title":"Evaluation of memory impairment in aging adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy","volume":"105","author":"GT Armstrong","year":"2013","journal-title":"JNCI-J NATL CANCER I"},{"key":"pone.0312536.ref031","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.psyneuen.2016.07.222","article-title":"Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood","volume":"73","author":"C Follin","year":"2016","journal-title":"PSYCHONEUROENDOCRINO"},{"issue":"4","key":"pone.0312536.ref032","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3346\/jkms.2015.30.4.463","article-title":"Neurocognitive outcome in survivors of childhood acute lymphoblastic leukemia: experience at a tertiary care hospital in Korea.","volume":"30","author":"SJ Kim","year":"2015","journal-title":"J KOREAN MED SCI"},{"issue":"14","key":"pone.0312536.ref033","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.3390\/cancers13143538","article-title":"Neurocognitive Outcomes in Pediatric Patients Following Brain Irradiation","volume":"13","author":"K Weusthof","year":"2021","journal-title":"CANCERS"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T18:32:47Z","timestamp":1731349967000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312536"}},"subtitle":[],"editor":[{"given":"Marta","family":"Tremolada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0312536","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}