{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T22:49:34Z","timestamp":1792968574300,"version":"4.5.0"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dong-A Co., Ltd.","award":["2019"],"award-info":[{"award-number":["2019"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    The gut microbiome influences neurological disorders through bidirectional communication between the gut and the brain, i.e., the gut-brain axis.\n                    <jats:italic>Artemisia asiatica ex<\/jats:italic>\n                    , an extract of\n                    <jats:italic>Artemisia asiatica<\/jats:italic>\n                    Nakai (Stillen\u00ae, DA-9601) has been reported to improve depression by increasing brain-derived neurotropic factor. Therefore, we hypothesized that DA-9601 can be a potential therapeutic candidate for Alzheimer\u2019s disease (AD) acting through the gut-brain axis. Four groups of Tg2576 mice were used as the animal model for AD: wild type mice (n = 6), AD mice (n = 6), and DA-9601-administered AD mice given dosages of 30mg\/kg\/day (DA_30mg; n = 6) or 100mg\/kg\/day (DA_100mg; n = 6). Microglial activation, blood\u2012brain barrier integrity, amyloid beta accumulation, cognitive behavior, and changes in the gut microbiome were analyzed. DA-9601 improved the cognitive behavior of mice (DA_30mg **p&lt;0.01; DA_100mg **p&lt;0.01) and reduced amyloid beta accumulation (DA_30mg ***p&lt;0.001; DA_100mg **p&lt;0.01). Increased Iba-1 and upregulation of claudin-5 (DA_30mg *p&lt;0.05) and occludin (DA_30mg **p&lt;0.01; DA_100mg ***p&lt;0.001) indicated altered microglial activation and improved blood\u2012brain barrier integrity.\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    was dramatically increased by DA-9601 administration (DA_30mg 47%; DA_100mg 61%). DA-9601 improved AD pathology with\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    dominance in the gut microbiome in a mouse model of AD, inferring that DA-9601 can affect AD through the gut-brain axis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0312670","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T13:23:17Z","timestamp":1730121797000},"page":"e0312670","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Artemisia asiatica ex on Akkermansia muciniphila dominance for modulation of Alzheimer\u2019s disease in mice"],"prefix":"10.1371","volume":"19","author":[{"given":"Mijung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Sung","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0277-6326","authenticated-orcid":true,"given":"Manho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"pone.0312670.ref001","first-page":"21","article-title":"Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases","author":"F Luo","year":"2020","journal-title":"International journal of molecular sciences"},{"issue":"1","key":"pone.0312670.ref002","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/07315724.2019.1683379","article-title":"Alzheimer\u2019s Disease and Parkinson\u2019s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals","volume":"39","author":"A Agnihotri","year":"2020","journal-title":"Journal of the American College of Nutrition"},{"key":"pone.0312670.ref003","first-page":"193","article-title":"Altered glucose metabolism in Alzheimer\u2019s disease: Role of mitochondrial dysfunction and oxidative stress","author":"S Dewanjee","year":"2022","journal-title":"Free radical biology & medicine"},{"issue":"5","key":"pone.0312670.ref004","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.14336\/AD.2019.1125","article-title":"Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer\u2019s Disease","volume":"11","author":"KY Wong","year":"2020","journal-title":"Aging and disease"},{"key":"pone.0312670.ref005","unstructured":"European Medicines Agency, Guideline on the Clinical Investigation of Medicines for the Treatment of Alzheimer\u2019s Disease. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-clinical-investigationmedicines-treatment-alzheimers-disease-revision-2_en.pdf (accessed on 20 June 2020)."},{"key":"pone.0312670.ref006","first-page":"11","article-title":"What Does the Brain Have to Keep Working at Its Best? Resilience Mechanisms Such as Antioxidants and Brain\/Cognitive Reserve for Counteracting Alzheimer\u2019s Disease Degeneration","author":"DM Cammisuli","year":"2022","journal-title":"Biology"},{"key":"pone.0312670.ref007","doi-asserted-by":"crossref","first-page":"105268","DOI":"10.1016\/j.neuint.2021.105268","article-title":"Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer\u2019s disease","volume":"153","author":"H Goshtasbi","year":"2022","journal-title":"Neurochemistry international"},{"issue":"1","key":"pone.0312670.ref008","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15212\/AMM-2021-0001","article-title":"PROTACs technology for treatment of Alzheimer\u2019s disease: Advances and perspectives","volume":"1","author":"H Inuzuka","year":"2022","journal-title":"Acta materia medica"},{"key":"pone.0312670.ref009","doi-asserted-by":"crossref","first-page":"118627","DOI":"10.1016\/j.lfs.2020.118627","article-title":"Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer\u2019s disease","volume":"264","author":"P Kesika","year":"2021","journal-title":"Life Sciences"},{"key":"pone.0312670.ref010","doi-asserted-by":"crossref","unstructured":"Narengaowa, Kong W, Lan F, Awan UF, Qing H, Ni J. The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer\u2019s Disease. Frontiers in cellular neuroscience. 2021;15:633735. Epub 2021\/05\/04. doi: 10.3389\/fncel.2021.633735. 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DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-&alpha; Production. Journal of Health Science. 2006;52(4):383\u20139. doi: 10.1248\/jhs.52.383.","DOI":"10.1248\/jhs.52.383"},{"issue":"2","key":"pone.0312670.ref039","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10565-006-0103-3","article-title":"DA-9601 inhibits activation of the human mast cell line HMC-1 through inhibition of NF-\u03baB","volume":"23","author":"S Lee","year":"2007","journal-title":"Cell Biology and Toxicology"},{"issue":"1","key":"pone.0312670.ref040","first-page":"483980","article-title":"Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage","volume":"2015","author":"JY Park","year":"2015","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1","key":"pone.0312670.ref041","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41387-020-0115-8","article-title":"Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse 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