{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:18:03Z","timestamp":1791328683862,"version":"4.3.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"QingPu Branch of Zhongshan Hospital Affiliated to Fudan University","award":["QYM2023-08"],"award-info":[{"award-number":["QYM2023-08"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia and frailty are common among elderly individuals and present substantial health hazards. Exploring their relationship is essential for optimizing geriatric healthcare, particularly within the context of China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population-based cross-sectional design was employed using data from the China Health and Retirement Longitudinal Study (CHARLS). The study enrolled 5,714 participants aged \u226560 years who underwent assessment for sarcopenia following the criteria established by the Asia Working Group for Sarcopenia (AWGS 2019) in 2019. Frailty status was determined using a frailty index that categorized participants into robustness, pre-frailty, and frailty stages. Multivariable logistic regression models were employed to examine the relationship between sarcopenia and frailty and pre-frailty conditions. Subgroup and interaction analyses were performed to explore the robustness of the associations between sarcopenia and frailty across different subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the participants, 1,028 (18.0%) were identified as frailty, 2,987 (52.3%) as pre-frailty, and 645 (11.3%) had sarcopenia. Sarcopenia demonstrated an independent association with higher risks of frailty (OR = 2.13, 95% CI: 1.52\u20132.99) and pre-frailty (OR = 1.42, 95% CI: 1.20\u20131.81) in the multivariable logistic analysis. Subgroup and interaction analyses consistently demonstrated significant associations across nearly all demographic and health-related subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights that sarcopenia is significantly and independently associated with frailty and pre-frailty among older adults in China. Early detection and targeted interventions for sarcopenia are crucial to mitigate frailty and its adverse health outcomes in aging populations, emphasizing the need for tailored healthcare strategies to promote healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0312879","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:36:08Z","timestamp":1730986568000},"page":"e0312879","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sarcopenia and frailty among older Chinese adults: Findings from the CHARLS study"],"prefix":"10.1371","volume":"19","author":[{"given":"Weiwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ahmed","family":"Al-Kaif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4883-8379","authenticated-orcid":true,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"pone.0312879.ref001","doi-asserted-by":"crossref","first-page":"102111","DOI":"10.1016\/j.arr.2023.102111","article-title":"Frailty and sarcopenia: A bibliometric analysis of their association and potential targets for intervention","volume":"92","author":"L. Ye","year":"2023","journal-title":"Ageing Res Rev"},{"key":"pone.0312879.ref002","doi-asserted-by":"crossref","first-page":"104755","DOI":"10.1016\/j.ijnurstu.2024.104755","article-title":"Prevalence of multidimensional frailty among community-dwelling older adults: A systematic review and meta-analysis","volume":"154","author":"Y. Qiu","year":"2024","journal-title":"Int J Nurs Stud"},{"issue":"3","key":"pone.0312879.ref003","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s41999-023-00930-7","article-title":"The prevalence of oral frailty among older adults: a systematic review and meta\u2011analysis","volume":"15","author":"T. Li","year":"2024","journal-title":"Eur Geriatr Med"},{"issue":"1","key":"pone.0312879.ref004","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12992-024-01056-6","article-title":"Internet use and frailty in middle-aged and older adults: findings from developed and developing countries","volume":"20","author":"L. Li","year":"2024","journal-title":"Global Health"},{"issue":"9","key":"pone.0312879.ref005","article-title":"Frailty and risk of cardiovascular disease and mortality","volume":"17","author":"X. Liu","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"pone.0312879.ref006","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12272-024-01493-2","article-title":"Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies","volume":"47","author":"Y. Zheng","year":"2024","journal-title":"Arch Pharm Res"},{"issue":"1","key":"pone.0312879.ref007","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jcsm.13160","article-title":"Cooper, C., Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts","volume":"14","author":"L. D. 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Antunes","year":"2017","journal-title":"Nutr Diet"},{"issue":"1","key":"pone.0312879.ref011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/1479972316679664","article-title":"Sarcopenia and frailty in chronic respiratory disease","volume":"14","author":"A. E. Bone","year":"2017","journal-title":"Chron Respir Dis"},{"issue":"4","key":"pone.0312879.ref012","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/jcsm.13275","article-title":"Association between sarcopenia and frailty in elderly patients with chronic kidney disease","volume":"14","author":"C. Wang","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"pone.0312879.ref013","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/heartjnl-2016-309995","article-title":"The challenge of frailty and sarcopenia in heart failure with preserved ejection fraction","volume":"103","author":"Y. 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