{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:25:09Z","timestamp":1774945509280,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council of Science and Technology-CONACYT","award":["CONACYT PINV 18-256"],"award-info":[{"award-number":["CONACYT PINV 18-256"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine the prevalence of genital infections (GIs), including sexual transmitted STIs: <jats:italic>Neisseria gonorrhoeae<\/jats:italic>, <jats:italic>Chlamydia trachomatis<\/jats:italic>, <jats:italic>Mycoplasma genitalium<\/jats:italic>, <jats:italic>Trichomonas vaginalis<\/jats:italic>, and opportunistic pathogens that generally do not cause STIs, non-classic STI: <jats:italic>Ureaplasma urealyticum<\/jats:italic>, <jats:italic>Ureaplasma parvum<\/jats:italic> and <jats:italic>Mycoplasma hominis<\/jats:italic>, in women with high-risk oncogenic human papillomavirus (hr-HPV) infection and their association with cervical lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A cross-sectional study was carried out including 231 hr-HPV positive women. Of these, 46 has histologically confirmed cervical intraepithelial neoplasia 3 (CIN3) or more (including CIN3 and cervical cancer lesions-CIN3+). GIs were detected by multiplex real time PCR. Odds ratios (OR) were estimated to explore possible associations between GIs and the presence or absence of CIN3+ lesions. Additionally, we examined associations between sociodemographic, sexual, and clinical characteristics and the presence of GIs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In total, there were 174\/231 cases of GIs corresponding to an overall prevalence of 75.3% (95%CI: 69.4\u201380.4), being non-classic STIs the most common (72.3%) compared to STIs (12.6%). The most prevalent non-classic STI and STI were <jats:italic>U<\/jats:italic>. <jats:italic>parvum<\/jats:italic> (49.8%) and <jats:italic>C<\/jats:italic>. <jats:italic>trachomatis<\/jats:italic> (7.4%), respectively. The odds of presenting GIs were 3 times higher in women under 46 years compared to older counterparts (OR: 3.32, 95%CI: 1.74\u20136.16), and in women with a normal Pap smear with inflammation compared to those without inflammation (OR: 3.31, 95%CI: 1.15\u20139.77). GIs were equally present in women with and without CIN3+ lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We observed an association of GIs with inflammation in the Pap smear, but no association with CIN3+, as some of them are very common and likely part of the normal vaginal flora, suggesting that such infections do not appear to be cofactors in cervical carcinogenesis, although larger prospective studies are needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0312947","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T17:37:52Z","timestamp":1730223472000},"page":"e0312947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genital infections in high-risk human papillomavirus positive Paraguayan women aged 30\u201364 with and without cervical lesions"],"prefix":"10.1371","volume":"19","author":[{"given":"Alanis","family":"Ar\u00e9valos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-8371","authenticated-orcid":true,"given":"Adriana","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7771-3688","authenticated-orcid":true,"given":"Pamela","family":"Mongel\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"B\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Centuri\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Vester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Soil\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Meza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malvina","family":"P\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Cristaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Soskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Deluca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-6911","authenticated-orcid":true,"given":"Armando","family":"Baena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Almonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Kasamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-1244","authenticated-orcid":true,"given":"Laura","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ESTAMPA Paraguayan Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"issue":"3","key":"pone.0312947.ref001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"74","author":"F Bray","year":"2024","journal-title":"CA Cancer J Clin."},{"key":"pone.0312947.ref002","volume-title":"Cervical Cancer Screening","author":"IARC Working Group on the Evaluation of Cancer-Preventive Interventions","year":"2022"},{"issue":"10451","key":"pone.0312947.ref003","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0140-6736(24)01097-3","article-title":"Causal attribution of human papillomavirus genotypes to invasive cervical cancer worldwide: a systematic analysis of the global literature","volume":"404","author":"F Wei","year":"2024","journal-title":"Lancet"},{"issue":"8","key":"pone.0312947.ref004","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cmi.2021.04.031","article-title":"2020 list of human papillomavirus assays suitable for primary cervical cancer screening","volume":"27","author":"M Arbyn","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"pone.0312947.ref005","first-page":"100593","article-title":"Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study.","volume":"26","author":"AT Ram\u00edrez","year":"2023","journal-title":"Lancet Reg Health Am"},{"issue":"4","key":"pone.0312947.ref006","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.micinf.2009.01.004","article-title":"Immunological\u2019s host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor","volume":"11","author":"AC Simonetti","year":"2009","journal-title":"Microbes Infect"},{"issue":"2","key":"pone.0312947.ref007","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0168-1702(02)00188-0","article-title":"Environmental co-factors in HPV carcinogenesis","volume":"89","author":"X Castellsagu\u00e9","year":"2002","journal-title":"Virus Res"},{"issue":"4","key":"pone.0312947.ref008","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/ijc.22357","article-title":"Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies.","volume":"120","author":"International Collaboration of Epidemiological Studies of Cervical Cancer","year":"2007","journal-title":"Int J Cancer"},{"issue":"5","key":"pone.0312947.ref009","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jnci\/djj067","article-title":"Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention","volume":"98","author":"X Castellsagu\u00e9","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"pone.0312947.ref010","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/ijc.21953","article-title":"Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies.","volume":"119","author":"International Collaboration of Epidemiological Studies of Cervical Cancer","year":"2006","journal-title":"Int J Cancer"},{"issue":"6","key":"pone.0312947.ref011","first-page":"1371","article-title":"Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion","volume":"6","author":"AL de Abreu","year":"2016","journal-title":"Am J Cancer Res"},{"issue":"1","key":"pone.0312947.ref012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/(SICI)1097-0215(20000101)85:1<35::AID-IJC6>3.0.CO;2-A","article-title":"Chlamydia trachomatis infection as a risk factor for invasive cervical cancer","volume":"85","author":"P Koskela","year":"2000","journal-title":"Int J Cancer"},{"issue":"3","key":"pone.0312947.ref013","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ijc.20257","article-title":"Chlamydia trachomatis and invasive cervical cancer: a pooled analysis of the IARC multicentric case-control study","volume":"111","author":"JS Smith","year":"2004","journal-title":"Int J Cancer"},{"key":"pone.0312947.ref014","first-page":"7640758","article-title":"Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions","volume":"2020","author":"H Zhong","year":"2020","journal-title":"Can J Infect Dis Med Microbiol J Can Mal Infect Microbiol M\u00e9dicale"},{"issue":"7","key":"pone.0312947.ref015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00007435-200307000-00009","article-title":"Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients","volume":"30","author":"PE Castle","year":"2003","journal-title":"Sex Transm Dis"},{"issue":"3","key":"pone.0312947.ref016","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/ijc.2910560311","article-title":"Sexually transmitted agents and cervical neoplasia in Colombia and Spain","volume":"56","author":"S de Sanjos\u00e9","year":"1994","journal-title":"Int J Cancer"},{"issue":"11","key":"pone.0312947.ref017","doi-asserted-by":"crossref","first-page":"e0207853","DOI":"10.1371\/journal.pone.0207853","article-title":"High prevalence of sexual Chlamydia trachomatis infection in young women from Maraj\u00f3 Island, in the Brazilian Amazon.","volume":"13","author":"LM dos Santos","year":"2018","journal-title":"PLOS ONE."},{"issue":"6","key":"pone.0312947.ref018","doi-asserted-by":"crossref","first-page":"e0287633","DOI":"10.1371\/journal.pone.0287633","article-title":"Prevalence of sexually transmissible infections in adolescents treated in a family planning outpatient clinic for adolescents in the western Amazon.","volume":"18","author":"IP Monteiro","year":"2023","journal-title":"PLOS ONE."},{"issue":"1","key":"pone.0312947.ref019","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40168-016-0203-0","article-title":"The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?","volume":"4","author":"A Mitra","year":"2016","journal-title":"Microbiome"},{"issue":"4","key":"pone.0312947.ref020","doi-asserted-by":"crossref","first-page":"e0153274","DOI":"10.1371\/journal.pone.0153274","article-title":"Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study.","volume":"11","author":"A Audirac-Chalifour","year":"2016","journal-title":"PloS One"},{"issue":"5","key":"pone.0312947.ref021","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/cancers12051093","article-title":"Mycoplasma Co-Infection Is Associated with Cervical Cancer Risk.","volume":"12","author":"C Klein","year":"2020","journal-title":"Cancers"},{"issue":"5","key":"pone.0312947.ref022","doi-asserted-by":"crossref","first-page":"e035796","DOI":"10.1136\/bmjopen-2019-035796","article-title":"Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: the ESTAMPA screening study protocol.","volume":"10","author":"M Almonte","year":"2020","journal-title":"BMJ Open"},{"issue":"6","key":"pone.0312947.ref023","doi-asserted-by":"crossref","first-page":"e0218016","DOI":"10.1371\/journal.pone.0218016","article-title":"Factors associated with high-risk human papillomavirus infection and high-grade cervical neoplasia: A population-based study in Paraguay.","volume":"14","author":"E Kasamatsu","year":"2019","journal-title":"PloS One"},{"issue":"1","key":"pone.0312947.ref024","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12985-022-01850-x","article-title":"Association between common vaginal and HPV infections and results of cytology test in the Zhoupu District, Shanghai City, China, from 2014 to 2019.","volume":"19","author":"H Li","year":"2022","journal-title":"Virol J"},{"key":"pone.0312947.ref025","doi-asserted-by":"crossref","first-page":"1145215","DOI":"10.3389\/fcimb.2023.1145215","article-title":"Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes","volume":"13","author":"D A","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"pone.0312947.ref026","doi-asserted-by":"crossref","first-page":"887736","DOI":"10.3389\/frph.2022.887736","article-title":"Microbiological and behavioral determinants of genital HPV infections among adolescent girls and young women warrant the need for targeted policy interventions to reduce HPV risk.","volume":"4","author":"H Onywera","year":"2022","journal-title":"Front Reprod Health."},{"key":"pone.0312947.ref027","first-page":"44","article-title":"Distribution of human papillomavirus (HPV) genotypes and bacterial vaginosis presence in cervical samples from Paraguayan indigenous.","volume":"39","author":"P Mongelos","year":"2015","journal-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis"},{"issue":"7","key":"pone.0312947.ref028","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-3156.2003.01078.x","article-title":"Sexually transmitted infections in a female population in rural north-east Brazil: prevalence, morbidity and risk factors","volume":"8","author":"V de Lima Soares","year":"2003","journal-title":"Trop Med Int Health TM IH"},{"issue":"1","key":"pone.0312947.ref029","doi-asserted-by":"crossref","first-page":"e0170189","DOI":"10.1371\/journal.pone.0170189","article-title":"Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland.","volume":"12","author":"TG Ginindza","year":"2017","journal-title":"PLOS ONE."},{"issue":"5","key":"pone.0312947.ref030","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.3802\/jgo.2016.27.e49","article-title":"Associations between sexually transmitted infections, high-risk human papillomavirus infection, and abnormal cervical Pap smear results in OB\/GYN outpatients.","volume":"27","author":"HS Kim","year":"2016","journal-title":"J Gynecol Oncol"},{"issue":"1","key":"pone.0312947.ref031","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1186\/1471-2458-14-1248","article-title":"Sexual behavior and factors associated with young age at first intercourse and HPV vaccine uptake among young women in Germany: implications for HPV vaccination policies.","volume":"14","author":"C Remschmidt","year":"2014","journal-title":"BMC Public Health"},{"key":"pone.0312947.ref032","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2015.04.019","article-title":"Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract","volume":"42","author":"MN Anahtar","year":"2015","journal-title":"Immunity"},{"key":"pone.0312947.ref033","doi-asserted-by":"crossref","first-page":"992176","DOI":"10.3389\/frph.2022.992176","article-title":"Role of the human vaginal microbiota in the regulation of inflammation and sexually transmitted infection acquisition: Contribution of the non-human primate model to a better understanding?","volume":"4","author":"C Adapen","year":"2022","journal-title":"Front Reprod Health."},{"key":"pone.0312947.ref034","doi-asserted-by":"crossref","first-page":"184302","DOI":"10.1155\/2013\/184302","article-title":"Inflammation on the cervical papanicolaou smear: evidence for infection in asymptomatic women?","volume":"2013","author":"S Baka","year":"2013","journal-title":"Infect Dis Obstet Gynecol."},{"issue":"4","key":"pone.0312947.ref035","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10096-016-2584-1","article-title":"Bacterial vaginosis, aerobic vaginitis, vaginal inflammation and major Pap smear abnormalities","volume":"35","author":"P Vieira-Baptista","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol"},{"issue":"1","key":"pone.0312947.ref036","first-page":"23","article-title":"The pathogenic microorganisms in papanicolaou vaginal smears and correlation with inflammation","volume":"7","author":"E Barouti","year":"2013","journal-title":"J Fam Reprod Health"},{"issue":"3","key":"pone.0312947.ref037","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3390\/microorganisms11030662","article-title":"Alterations of Vaginal Microbiota and Chlamydia trachomatis as Crucial Co-Causative Factors in Cervical Cancer Genesis Procured by HPV.","volume":"11","author":"C Gargiulo Isacco","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"pone.0312947.ref038","first-page":"e21331","article-title":"The Rol of Chlamydia Trachomatis in the Pathogenesis of Cervical Cancer.","volume":"14","author":"AP Arcia Franchini","year":"2022","journal-title":"Cureus"},{"key":"pone.0312947.ref039","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1590\/s1678-9946202163001","article-title":"High molecular prevalence of HPV and other sexually transmitted infections in a population of asymptomatic women who work or study at a Brazilian university.","volume":"63","author":"TT Suehiro","year":"2021","journal-title":"Rev Inst Med Trop Sao Paulo."},{"issue":"1","key":"pone.0312947.ref040","first-page":"30","article-title":"Chlamydia trachomatis infection: Screening and management.","volume":"21","author":"M.B. Keegan","year":"2014","journal-title":"Clin Outcomes Manag."},{"key":"pone.0312947.ref041","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijid.2014.03.1389","article-title":"Sexually transmitted bacterial infections among young women in Central Western Brazil. Brazil","volume":"25","author":"YA Lima","journal-title":"Int J Infect Dis"},{"key":"pone.0312947.ref042","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-9378-9-30","article-title":"High prevalence of hpv multiple genotypes in women with persistent chlamydia trachomatis infection","volume":"9","author":"S Seraceni","year":"2014","journal-title":"Infect Agents Cancer"},{"key":"pone.0312947.ref043","doi-asserted-by":"crossref","first-page":"e54022","DOI":"10.1371\/journal.pone.0054022","article-title":"Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model.","volume":"8","author":"AE Knowlton","year":"2013","journal-title":"PLoS One."},{"key":"pone.0312947.ref044","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fmicb.2020.00827","article-title":"Chlamydia trachomatis and human papillomavirus infection in women from Southern Hunan province in China: a large observational study.","volume":"11","author":"H Chen","year":"2020","journal-title":"Front Microbiol."},{"key":"pone.0312947.ref045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13027-016-0111-8","article-title":"Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16\/Ki-67 dual-staining","volume":"12","author":"R Robial","year":"2017","journal-title":"Infect Agent Cancer"},{"issue":"12","key":"pone.0312947.ref046","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jiac.2017.08.008","article-title":"Influence of co-infection complicated with human papillomavirus on cervical intraepithelial neoplasia development in patients with atypical squamous cells of undetermined significance","volume":"23","author":"H Kiseki","journal-title":"J Infect Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T17:38:05Z","timestamp":1730223485000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0312947"}},"subtitle":[],"editor":[{"given":"David","family":"Mori\u00f1a Soler","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0312947","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]}}}