{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T06:09:54Z","timestamp":1766297394417,"version":"3.40.5"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Progranulin is a secreted glycoprotein that regulates inflammation and wound healing. However, plasma progranulin levels in the acute phase and their clinical significance in patients with acute myocardial infarction (AMI) remain to be elucidated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>We aimed to investigate the relationship between the increase in plasma progranulin levels in the acute phase and the recovery of left ventricular function in the chronic phase in AMI patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Method and result<\/jats:title>\n<jats:p>Eighteen AMI patients were followed up for 6 months. Blood samples were collected from the antecubital vein on day 0 (on admission) and day 7 in the acute phase. The control group consisted of patients without significant coronary artery stenosis, as assessed by cardiac catheterization (n = 16). Plasma progranulin levels were measured by enzyme-linked immunosorbent assay. Echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI to evaluate left ventricular ejection fraction using the modified Simpson\u2019s method. Plasma progranulin levels in the AMI group on day 0 (69.5 \u00b1 24.6 ng\/mL) were similar to those in the control group (84.2 \u00b1 47.1 ng\/mL). There was a significant increase in progranulin levels in the AMI group on day 7 (104.2 \u00b1 52.0 ng\/mL) compared with day 0. The increase in plasma progranulin levels in the acute phase was positively correlated with the increase in left ventricular ejection fraction between the acute and chronic phases. Among various factors, only plasma progranulin levels were favorably correlated with left ventricular functional recovery in the chronic phase.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The increase in plasma progranulin levels in the acute phase may serve as a predictive biomarker and a contributer for the recovery of left ventricular function in the chronic phase in patients with AMI.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313014","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:31:53Z","timestamp":1731090713000},"page":"e0313014","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated plasma progranulin levels in the acute phase are correlated with recovery of left ventricular function in the chronic phase in patients with acute myocardial infarction"],"prefix":"10.1371","volume":"19","author":[{"given":"Shingo","family":"Minatoguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Satake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yoshizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaaki","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Ojio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-9697","authenticated-orcid":true,"given":"Shinya","family":"Minatoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"pone.0313014.ref001","doi-asserted-by":"crossref","first-page":"662","DOI":"10.2741\/4234","article-title":"The role of PGRN in muscuoskeletal development and disease","volume":"19","author":"J Konopka","year":"2014","journal-title":"Front Biosci"},{"key":"pone.0313014.ref002","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1177\/002215540004800713","article-title":"Cellular localization of gene expression for progranulin","volume":"48","author":"R Daniel","year":"2000","journal-title":"J. Histochem. Cytochem"},{"key":"pone.0313014.ref003","first-page":"2438","article-title":"Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin","volume":"118","author":"K Kessenbrock","year":"2008","journal-title":"J. Clin. Invest"},{"key":"pone.0313014.ref004","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20091568","article-title":"Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice","volume":"207","author":"F Yin","year":"2010","journal-title":"J Exp Med"},{"key":"pone.0313014.ref005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm816","article-title":"Progranulin is a mediator of the wound response","volume":"9","author":"Z He","year":"2003","journal-title":"Nat. Med"},{"key":"pone.0313014.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-01587-6","article-title":"Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation","volume":"7","author":"M Hosokawa","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0313014.ref007","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1199214","article-title":"The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice","volume":"332","author":"W Tang","year":"2011","journal-title":"Science"},{"key":"pone.0313014.ref008","first-page":"1","article-title":"Progranulin as a prognostic biomarker for breast cancer recurrence in patients who had hormone receptor-positive tumors: A cohort study","volume":"7","author":"DH Koo","year":"2012","journal-title":"PLoS One"},{"key":"pone.0313014.ref009","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1742-2094-10-105","article-title":"The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment.","volume":"10","author":"Y Egashira","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"pone.0313014.ref010","doi-asserted-by":"crossref","first-page":"11842","DOI":"10.1038\/s41598-020-68804-7","article-title":"Effects of progranulin on the pathological conditions in experimental myocardial infarction model.","volume":"10","author":"T Sasaki","year":"2020","journal-title":"Scientific Rep"},{"key":"pone.0313014.ref011","doi-asserted-by":"crossref","first-page":"e028475","DOI":"10.1161\/JAHA.122.028475","article-title":"Impact of complete revascularization on development of heart failure in patients with acute coronary syndrome and multivessel disease: a subanalysis of the coralys registry","volume":"12","author":"F Bruno","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"pone.0313014.ref012","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/ki.2014.403","article-title":"Progranulin protects against renal ischemia \/ reperfusion injury in mice","volume":"87","author":"M Zhou","year":"2015","journal-title":"Kidney Int"},{"key":"pone.0313014.ref013","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"M Nian","year":"2004","journal-title":"Circ Res"},{"key":"pone.0313014.ref014","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1161\/01.CIR.0000129770.93985.3E","article-title":"Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment","volume":"109","author":"S Minatoguchi","year":"2004","journal-title":"Circulation"},{"key":"pone.0313014.ref015","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/brain\/awv079","article-title":"Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke","volume":"138","author":"M Kanazawa","year":"2015","journal-title":"Brain"},{"key":"pone.0313014.ref016","first-page":"e928864","article-title":"Serum progranulin as a risk predictor in patients with acute myocardial infarction","volume":"27","author":"T Zhou","year":"2021","journal-title":"Med Sci Monit"},{"key":"pone.0313014.ref017","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-2840-13-14","article-title":"Implications of C1q\/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris.","volume":"13","author":"KM Choi","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"pone.0313014.ref018","first-page":"672","article-title":"Change in left ventricular ejection fraction following first myocardial infarction and outcome","volume":"4","author":"DS Chew","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"pone.0313014.ref019","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0735-1097(94)00431-O","article-title":"Relation of initial infarct size to extent of left ventricular remodeling in the year after acute myocardial infarction","volume":"25","author":"P Chareonthaitawee","year":"1995","journal-title":"J Am Coll Cardiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:32:07Z","timestamp":1731090727000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313014"}},"subtitle":[],"editor":[{"given":"Wannaporn","family":"Ittiprasert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313014","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2024,11,8]]}}}