{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:21:24Z","timestamp":1791591684263,"version":"4.3.4"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.104\/2021"],"award-info":[{"award-number":["E-26\/211.104\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.708719\/2022-01"],"award-info":[{"award-number":["88881.708719\/2022-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.708718\/2022-00"],"award-info":[{"award-number":["88887.708718\/2022-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.466981\/2019-00"],"award-info":[{"award-number":["88887.466981\/2019-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/201.398\/2021"],"award-info":[{"award-number":["E-26\/201.398\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To assess the effects of neural mobilisation on nerve function and nerve structure of patients with peripheral neuropathic pain.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A systematic review with meta-analysis was conducted. Medline, Embase, CINAHL, Cochrane Library, and World Health Organization International Clinical Trials Registry Platform were searched without restrictions. Eligibility criteria included controlled trials or quasi-experimental studies comparing neural mobilisation versus sham, active or inactive control in adults with peripheral neuropathic pain. Primary outcomes were the change in peripheral nerve cross-sectional area. Secondary outcomes included nerve echogenicity, nerve excursion and nerve conduction. Random effects meta-analysis was conducted. Risk of bias was assessed with the Cochrane Collaboration tool, and certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation framework.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Eleven randomised controlled trials and four quasi-experimental studies (total sample = 722 participants) were included. Thirteen studies included participants with carpal tunnel syndrome. Two studies examined the cross-sectional area, revealing improvements (i.e., a reduction) in the cross-sectional area after the neural mobilisation. Neural mobilisation improved motor [mean difference = 2.95 (95%CI 1.67 to 4.22)] and sensory conduction velocity in short-term [mean difference = 11.74 (95%CI 7.06 to 16.43)], compared to control. Neural mobilisation did not alter distal motor or sensory latency.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Neural mobilisation seems to improve (i.e., a reduced) the cross-sectional area (very low-quality evidence) and sensory conduction velocity (very low-quality evidence). Neural mobilisation was superior to control in improving motor conduction velocity in patients with peripheral neuropathic pain with moderate quality evidence. Distal motor or sensory latency presented similar results compared to other interventions. Our findings should be interpreted cautiously since most studies included patients with carpal tunnel syndrome.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313025","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:37:41Z","timestamp":1731091061000},"page":"e0313025","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neural mobilisation effects in nerve function and nerve structure of patients with peripheral neuropathic pain: A systematic review with meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-8523","authenticated-orcid":true,"given":"Juliana Valentim","family":"Bittencourt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Amaral","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice Mainenti","family":"Pagnez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-3325","authenticated-orcid":true,"given":"J\u00e9ssica Pinto Martins","family":"do Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-9429","authenticated-orcid":true,"given":"Gustavo Felicio","family":"Telles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Mathieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Alberto Calazans","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"3","key":"pone.0313025.ref001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","article-title":"Prevalence of chronic pain with neuropathic characteristics in the general population","volume":"136","author":"D Bouhassira","year":"2008","journal-title":"Pain"},{"issue":"4","key":"pone.0313025.ref002","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"O van Hecke","year":"2014","journal-title":"Pain"},{"issue":"2","key":"pone.0313025.ref003","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jpain.2006.06.005","article-title":"Symptom profiles differ in patients with neuropathic versus non-neuropathic pain","volume":"8","author":"RH Dworkin","year":"2007","journal-title":"J pain"},{"issue":"2","key":"pone.0313025.ref004","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.math.2008.01.009","article-title":"A neuropathic pain component is common in acute whiplash and associated with a more complex clinical presentation","volume":"14","author":"M Sterling","year":"2009","journal-title":"Man Ther"},{"issue":"3","key":"pone.0313025.ref005","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0304-3959(03)00078-2","article-title":"Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery","volume":"104","author":"M Sterling","year":"2003","journal-title":"Pain"},{"issue":"1","key":"pone.0313025.ref006","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3959(96)03221-6","article-title":"The initial effects of a cervical spine manipulative physiotherapy treatment on the pain and dysfunction of lateral epicondylalgia","volume":"68","author":"B Vicenzino","year":"1996","journal-title":"Pain"},{"issue":"7","key":"pone.0313025.ref007","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1742-1241.2006.00867.x","article-title":"Comparison of three conservative treatment protocols in carpal tunnel syndrome.","volume":"60","author":"O Baysal","year":"2006","journal-title":"Int J Clin Pract."},{"issue":"8","key":"pone.0313025.ref008","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1097\/j.pain.0000000000002919","article-title":"Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. 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