{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:32:03Z","timestamp":1783654323567,"version":"3.55.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To determine the clinical, laboratory, and hospital factors associated with preoperative complications in older adults with hip fractures.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology<\/jats:title>\n<jats:p>Analytical observational retrospective cohort study, whose population was older adults with a diagnosis of hip fracture treated in a hospital in northern Peru, during 2017\u20132019.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>432 patients with a median age of 83 years (RIC: 77\u201388) were evaluated, with the female gender being the most prevalent (60.9%). The most common comorbidities included cardiovascular disease (68%) and diabetes (17.6%), and multimorbidity was observed in 47.2% of cases. The median number of geriatric syndromes was 2 (RIC: 1\u20135). The overall mortality rate was 3.2% (1.7\u20135.3). Analysis with the Poisson regression model found a significant association with MRC scale 3\u20135 degree (RR = 1.60), glucose on admission (RR = 1.01), and minimally significantly female sex (RR = 2.41).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The most commonly observed complications were infectious in nature, including pneumonia, sepsis, and urinary tract infections. The MRC scale from 3 to 5 degrees increases the risk of developing a preoperative complication; the glucose levels upon admission show a clinically irrelevant association; and in females, there is a minimally significant association in older adults with hip fractures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313089","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:22:13Z","timestamp":1730744533000},"page":"e0313089","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical, laboratory, and hospital factors associated with preoperative complications in Peruvian older adults with hip fracture"],"prefix":"10.1371","volume":"19","author":[{"given":"Edwin","family":"Aguirre-Milachay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-0204","authenticated-orcid":true,"given":"Darwin A.","family":"Le\u00f3n-Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-2419","authenticated-orcid":true,"given":"Mario J.","family":"Valladares-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"pone.0313089.ref001","unstructured":"Catalana S, Gerontolog\u00eda DEGI. GUIA D\u2019ORTOGERIATRIA SOCIETAT CATALANA DE GERIATRIA I GERONTOLOGIA. 2015."},{"key":"pone.0313089.ref002","unstructured":"Bunning T, Dickinson R, Fagan E, Inman D, Johansen A, Judge A, et al. National Hip Fracture Database (NHFD). Annual report September 2018. vol. September. 2018."},{"key":"pone.0313089.ref003","unstructured":"Academy A, Board OS. MANAGEMENT OF HIP FRACTURES IN THE ELDERLY. EVIDENCE- BASED CLINICAL PRACTICE GUIDELINE. 2014."},{"key":"pone.0313089.ref004","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4067\/s0034-98872017001101437","article-title":"Optimizaci\u00f3n perioperatoria del paciente anciano con fractura osteopor\u00f3tica de cadera","volume":"145","author":"F Bengoa","year":"2017","journal-title":"Rev Med Chil"},{"key":"pone.0313089.ref005","doi-asserted-by":"crossref","DOI":"10.1007\/s11657-017-0376-6","article-title":"Trends in osteoporotic hip fracture epidemiology over a 17-year period in a Spanish population: Alcorc\u00f3n 1999\u20132015","volume":"12","author":"R Mazzucchelli Esteban","year":"2017","journal-title":"Arch Osteoporos"},{"key":"pone.0313089.ref006","unstructured":"Royal College of Physicians. National Hip Fracture Database annual report 2016. 2016."},{"key":"pone.0313089.ref007","doi-asserted-by":"crossref","first-page":"42","DOI":"10.35663\/amp.2021.381.1844","article-title":"Caracter\u00edsticas cl\u00ednicas y epidemiol\u00f3gicas en adultos mayores con diagn\u00f3stico de fractura de cadera en un hospital de Lima, Per\u00fa","volume":"38","author":"E. Gutierrez","year":"2021","journal-title":"Acta Medica Peru"},{"key":"pone.0313089.ref008","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1016\/j.injury.2015.10.025","article-title":"Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review","volume":"46","author":"TC Marufu","year":"2015","journal-title":"Injury"},{"key":"pone.0313089.ref009","first-page":"121","article-title":"Assessment of clinical complications and their associated factors in hip-fracture patients in an Acute Geriatric Orthopaedic Unit","volume":"53","author":"R Bielza","year":"2018","journal-title":"Rev Espanola Geriatr Gerontol"},{"key":"pone.0313089.ref010","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00774-017-0869-9","article-title":"Characteristics of patients with fragility hip fractures in the northern Kyushu district in Japan: a multicenter prospective registry based on an electronic data capture system","volume":"36","author":"A Oyamada","year":"2018","journal-title":"J Bone Miner Metab"},{"key":"pone.0313089.ref011","first-page":"65","article-title":"Frecuencia de complicaciones en pacientes mayores de 60 a\u00f1os con fractura de cadera","volume":"32","author":"A Barrios-Moyano","year":"2018","journal-title":"Acta Ortop\u00e9dica Mex"},{"key":"pone.0313089.ref012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.35663\/amp.2016.331.13","article-title":"Fractura de cadera en el adulto mayor: la epidemia ignorada en el Per\u00fa","volume":"33","author":"L Palomino","year":"2016","journal-title":"Acta Med Peru"},{"key":"pone.0313089.ref013","unstructured":"The National Hip Fracture Database n.d. https:\/\/www.nhfd.co.uk\/ (accessed February 12, 2024)."},{"key":"pone.0313089.ref014","unstructured":"Hip Fracture Registry Toolbox. APFFA n.d. https:\/\/apfracturealliance.org\/hfr-toolbox\/ (accessed February 12, 2024)."},{"key":"pone.0313089.ref015","doi-asserted-by":"crossref","first-page":"13933","DOI":"10.1038\/s41598-018-32098-7","article-title":"Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis","volume":"8","author":"T Klestil","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0313089.ref016","first-page":"261","article-title":"Instrumentos de Valoraci\u00f3n Geri\u00e1trica Integral en los servicios de Geriatr\u00eda de Espa\u00f1a: uso heterog\u00e9neo de nuestra principal herramienta de trabajo","volume":"35","author":"P Abizanda Soler","year":"2000","journal-title":"Rev Esp Geriatr\u00eda Gerontol"},{"key":"pone.0313089.ref017","unstructured":"Jim\u00e9nez MAnt\u00f3n. Tratado de geriatr\u00eda para residentes. Madrid: Sociedad Espa\u00f1ola de Geriatr\u00eda y Gerontolog\u00eda; 2007."},{"key":"pone.0313089.ref018","article-title":"Retrospective observational studies: Lights and shadows for medical writers","volume":"93","author":"V DS","year":"2022","journal-title":"Acta Bio-Medica Atenei Parm"},{"key":"pone.0313089.ref019","first-page":"1390","article-title":"An Orthogeriatric Collaborative Intervention Program for Fragility Fractures: A Retrospective Cohort Study","volume":"71","author":"AH-C Leung","year":"2011","journal-title":"J Trauma Inj Infect Crit Care"},{"key":"pone.0313089.ref020","unstructured":"Baranowski P, P\u0142usa T, Baranowska A, Miku\u0142a W, Matuszewski P, Wydra T, et al. Analysis of mortality between 2019\u20132020 at the Neuroorthopedic and Traumatic Orthopedic Departments n.d."},{"key":"pone.0313089.ref021","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/ageing\/afu011","article-title":"Orthogeriatrics moving forward","volume":"43","author":"D Aw","year":"2014","journal-title":"Age Ageing"},{"key":"pone.0313089.ref022","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/CORR.0000000000001038","article-title":"Is Delayed Time to Surgery Associated with Increased Short-term Complications in Patients with Pathologic Hip Fractures?","volume":"478","author":"NH Varady","year":"2020","journal-title":"Clin Orthop"},{"key":"pone.0313089.ref023","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/BOT.0000000000001026","article-title":"Prediction Model of In-Hospital Mortality After Hip Fracture Surgery","volume":"32","author":"A Endo","year":"2018","journal-title":"J Orthop Trauma"},{"key":"pone.0313089.ref024","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00540-018-2494-8","article-title":"Impact of age on postoperative complication rates among elderly patients with hip fracture: a retrospective matched study","volume":"32","author":"M Matsuo","year":"2018","journal-title":"J Anesth"},{"key":"pone.0313089.ref025","article-title":"Risk factors for the development of aspiration pneumonia in elderly patients with femoral neck and trochanteric fractures: A retrospective study of a patient cohort","volume":"99","author":"T Higashikawa","year":"2020","journal-title":"Med U S"},{"key":"pone.0313089.ref026","doi-asserted-by":"crossref","first-page":"185","DOI":"10.26574\/maedica.2020.15.2.185","article-title":"Gender and Age Differences in Hip Fracture Types among Elderly: a Retrospective Cohort Study","volume":"15","author":"K Alpantaki","year":"2020","journal-title":"Maedica"},{"key":"pone.0313089.ref027","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/jcm10030540","article-title":"Mortality and Medical Complications of Subtrochanteric Fracture Fixation","volume":"10","author":"M Panteli","year":"2021","journal-title":"J Clin Med"},{"key":"pone.0313089.ref028","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s40520-023-02692-5","article-title":"Association of preoperative frailty with the risk of postoperative delirium in older patients undergoing hip fracture surgery: a prospective cohort study","volume":"36","author":"C Feng","year":"2024","journal-title":"Aging Clin Exp Res"},{"key":"pone.0313089.ref029","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.injury.2021.05.045","article-title":"Chronic kidney disease patients with intertrochanteric fracture have a high mortality rate","volume":"52","author":"TW Kim","year":"2021","journal-title":"Injury"},{"key":"pone.0313089.ref030","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3390\/jcm9072076","article-title":"The Association between High Body Mass Index and Early Clinical Outcomes in Patients with Proximal Femur Fractures","volume":"9","author":"M M\u00fcller","year":"2020","journal-title":"J Clin Med"},{"key":"pone.0313089.ref031","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/BOT.0000000000000825","article-title":"Obesity Is Associated With High Perioperative Complications Among Surgically Treated Intertrochanteric Fracture of the Femur","volume":"31","author":"H Kempegowda","year":"2017","journal-title":"J Orthop Trauma"},{"key":"pone.0313089.ref032","doi-asserted-by":"crossref","first-page":"e0158607","DOI":"10.1371\/journal.pone.0158607","article-title":"In Hospital and 3-Month Mortality and Functional Recovery Rate in Patients Treated for Hip Fracture by a Multidisciplinary Team","volume":"11","author":"C Rostagno","year":"2016","journal-title":"PLOS ONE"},{"key":"pone.0313089.ref033","first-page":"162","article-title":"Co-morbidities in Patients with a Hip Fracture","volume":"88","author":"R Lloyd","year":"2019","journal-title":"Ulster Med J"},{"key":"pone.0313089.ref034","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.110084","article-title":"Associations between presence of diabetes, mortality and fracture type in individuals with a hip fracture","volume":"192","author":"B Spaetgens","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"pone.0313089.ref035","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s40520-019-01134-5","article-title":"Relationship between comorbidities and treatment decision-making in elderly hip fracture patients","volume":"31","author":"J Wei","year":"2019","journal-title":"Aging Clin Exp Res"},{"key":"pone.0313089.ref036","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12891-023-07123-0","article-title":"Risk factors for hospital-acquired pneumonia in hip fracture patients: a systematic review and meta-analysis","volume":"25","author":"W Yao","year":"2024","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0313089.ref037","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2147\/CIA.S115945","article-title":"Dementia and delirium, the outcomes in elderly hip fracture patients","volume":"12","author":"CA Mosk","year":"2017","journal-title":"Clin Interv Aging"},{"key":"pone.0313089.ref038","article-title":"The Surgical Timing and Prognoses of Elderly Patients with Hip Fractures: A Retrospective Analysis","volume":"18","author":"L S","year":"2023","journal-title":"Clin Interv Aging"},{"key":"pone.0313089.ref039","article-title":"Influence of time to surgery on clinical outcomes in elderly hip fracture patients: an assessment of surgical postponement due to non-medical reasons","volume":"104-B","author":"R Vajim van","year":"2022","journal-title":"Bone Jt J"},{"key":"pone.0313089.ref040","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1302\/0301-620X.104B12.BJJ-2022-0340.R1","article-title":"Decompression alone or decompression with fusion for lumbar spinal stenosis: a randomized clinical trial with two-year MRI follow-up","volume":"104-B","author":"T Karlsson","year":"2022","journal-title":"Bone Jt J"},{"key":"pone.0313089.ref041","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1186\/s12891-023-06829-5","article-title":"Association between admission hyperglycemia and postoperative pneumonia in geriatric patients with hip fractures","volume":"24","author":"W Tang","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0313089.ref042","unstructured":"Ji S, Li Z, Li M, Lu Y, Ma T, Qi H, et al. Relationship between neutrophil\/lymphocyte ratio and postoperative delirium in elderly patients with proximal femoral nail anti-rotation for intertrochanteric fractures n.d."},{"key":"pone.0313089.ref043","article-title":"Preoperative Serum Albumin Level As A Predictor Of Postoperative Pneumonia After Femoral Neck Fracture Surgery In A Geriatric Population","volume":"14","author":"Y W","year":"2019","journal-title":"Clin Interv Aging"},{"key":"pone.0313089.ref044","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1302\/2633-1462.46.BJO-2023-0045.R1","article-title":"Delirium in hip fracture patients admitted from home during the COVID-19 pandemic is associated with higher mortality, longer total length of stay, need for post-acute inpatient rehabilitation, and readmission to acute services","volume":"4","author":"RS Penfold","year":"2023","journal-title":"Bone Jt Open"},{"key":"pone.0313089.ref045","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1177\/00031348211058629","article-title":"Frailty Score as a Predictor of Outcomes in Geriatric Patients with Isolated Hip Fractures","volume":"89","author":"WA Sang","year":"2023","journal-title":"Am Surg"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:22:31Z","timestamp":1730744551000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313089"}},"subtitle":[],"editor":[{"given":"Barry","family":"Kweh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313089","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]}}}