{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:11:55Z","timestamp":1781248315819,"version":"3.54.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["VEAP7973"],"award-info":[{"award-number":["VEAP7973"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Congenital cytomegalovirus disease (cCMV) can have significant sensory and neurodevelopmental sequelae throughout childhood. Many of these sequalae are consistent with special education eligibility, but the special education needs of affected children have not been systematically studied.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective chart reviews from two cohorts of cCMV children receiving care in a large tertiary care children\u2019s hospital were included in this study: a historical research cohort (N = 186, 41% symptomatic at birth) and a contemporary clinical cohort of cCMV patients (N = 112, 68% symptomatic at birth). SNOMED-CT was used to identify ICD-10 codes describing special education-qualifying health outcomes fitting the Individuals with Disabilities Education Act (IDEA) criteria. ICD-10 codes were retrospectively applied to the historical research cohort through manual chart review, whereas the ICD-10 billing codes were extracted from the electronic medical record for all encounters in the contemporary cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of the 56 unique special education-qualifying ICD-10 codes we identified as pertinent to the IDEA, at least one was noted in 39% of those asymptomatic at birth (AcCMV) as compared to 94% of the patients symptomatic at birth (ScCMV). In the contemporary clinical cohort, at least one of these codes was noted in 67% of the AcCMV patients as compared to 95% for ScCMV patients. 61% of patients in the historical and 86% in the contemporary cohort had at least one special education-qualifying ICD-10 code. Developmental, mobility, physical therapy and hearing-related health outcomes were common in both ScCMV and AcCMV patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Health outcomes qualifying for special educational services occur commonly in children with cCMV, including those who are classified as asymptomatic at birth. The emergence of qualifying conditions beyond the neonatal period among these children suggests that continued surveillance of this vulnerable population throughout early childhood may facilitate the timely identification of health outcomes requiring special educational services.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313163","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:38:01Z","timestamp":1734633481000},"page":"e0313163","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Healthcare outcomes and special education eligibility in children with congenital CMV"],"prefix":"10.1371","volume":"19","author":[{"given":"Ryan","family":"Rochat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-1434","authenticated-orcid":true,"given":"Jerry","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail J.","family":"Demmler-Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"Suppl 4","key":"pone.0313163.ref001","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.jcv.2009.09.002","article-title":"Congenital cytomegalovirus (CMV) epidemiology and awareness","volume":"46","author":"J Cannon M","year":"2009","journal-title":"J Clin Virol"},{"key":"pone.0313163.ref002","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"A Kenneson","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"pone.0313163.ref003","article-title":"Hearing Loss in Children With Asymptomatic Congenital Cytomegalovirus Infection","volume":"139","author":"M Lanzieri T","year":"2017","journal-title":"Pediatrics"},{"key":"pone.0313163.ref004","first-page":"505","article-title":"Cytomegalovirus urinary excretion and long term outcome in children with congenital cytomegalovirus infection","volume":"19","author":"Congenital CMV Longitudinal Study Group","year":"2000","journal-title":"PediatrInfect. Dis. 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J."},{"key":"pone.0313163.ref007","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3928\/01913913-20190311-01","article-title":"Cortical Visual Impairment in Congenital Cytomegalovirus Infection","volume":"56","author":"D Jin H","year":"2019","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"pone.0313163.ref008","doi-asserted-by":"crossref","first-page":"e20171517","DOI":"10.1542\/peds.2017-1517","article-title":"Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection","volume":"140","author":"S Lopez A","year":"2017","journal-title":"Pediatrics"},{"key":"pone.0313163.ref009","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/DBP.0000000000000740","article-title":"Inattention and Hyperactivity in Children with Symptomatic and Asymptomatic Congenital Cytomegalovirus","volume":"40","author":"D Topham J","year":"2019","journal-title":"J Dev Behav Pediatr"},{"key":"pone.0313163.ref010","unstructured":"US D.O.E. 2021 The Individuals with Disabilities Education Act (IDEA) https:\/\/sites.ed.gov\/idea\/."},{"key":"pone.0313163.ref011","doi-asserted-by":"crossref","first-page":"e0238102","DOI":"10.1371\/journal.pone.0238102","article-title":"Neurological and growth outcomes in South African children with congenital cytomegalovirus: A cohort study","volume":"15","author":"J Pathirana","year":"2020","journal-title":"PLoS One"},{"key":"pone.0313163.ref012","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/archdischild-2018-316010","article-title":"Economic cost of congenital CMV in the UK Arch","volume":"104","author":"J Retzler","year":"2019","journal-title":"Dis. Child"},{"key":"pone.0313163.ref013","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/archdischild-2017-312805","article-title":"Healthcare costs attributable to congenital cytomegalovirus infection","volume":"103","author":"J Korndewal M","year":"2018","journal-title":"Arch Dis Child"},{"key":"pone.0313163.ref014","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.clinthera.2019.04.022","article-title":"The Economic Burden of Congenital Cytomegalovirus Disease in the First Year of Life: A Retrospective Analysis of Health Insurance Claims Data in the United States","volume":"41","author":"J Meyers","year":"2019","journal-title":"Clin Ther"},{"key":"pone.0313163.ref015","first-page":"121","volume-title":"How to save money: congenital CMV infection and the economy Congenital Cytomegalovirus Infection ed G Halwachs-Baumann","author":"E Walter","year":"2011"},{"key":"pone.0313163.ref016","doi-asserted-by":"crossref","first-page":"F501","DOI":"10.1136\/archdischild-2014-306756","article-title":"First estimates of the potential cost and cost saving of protecting childhood hearing from damage caused by congenital CMV infection","author":"J Williams E","year":"2015","journal-title":"Arch. 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J. Obstet. Gynecol."},{"key":"pone.0313163.ref022","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archpedi.1982.03970460032007","article-title":"Symptomatic congenital cytomegalovirus. Disorders of language, learning, and hearing","volume":"136","author":"D Williamson W","year":"1982","journal-title":"Am J Dis Child"},{"key":"pone.0313163.ref023","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/jp.2017.41","article-title":"Long-term outcomes of children with symptomatic congenital cytomegalovirus disease","volume":"37","author":"M Lanzieri T","year":"2017","journal-title":"J Perinatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:38:12Z","timestamp":1734633492000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313163"}},"subtitle":[],"editor":[{"given":"Fumihiko","family":"Namba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313163","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}