{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T19:10:11Z","timestamp":1736449811167,"version":"3.32.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008021","name":"Bristol-Myers Squibb Canada","doi-asserted-by":"publisher","award":["L1FD"],"award-info":[{"award-number":["L1FD"]}],"id":[{"id":"10.13039\/100008021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nIn recent years, cancer survival rates have increased exponentially. However, this rise in survival comes with a significant drawback. As the number of treatment lines has grown, so too have the side effects, which can severely impact patients\u2019 functionality and quality of life. One of the most concerning effects is dyspnoea, a serious health issue that imposes substantial limitations on individuals. While traditional clinical approaches, primarily focused on pharmacological interventions, are commonly employed to manage dyspnoea, we argue that these methods may not always provide optimal symptomatic relief. Therefore, we propose a study protocol to implement an interdisciplinary intervention for these patients. This protocol aims to enhance standard clinical practice by introducing a program of functional re-education and environmental adaptation. We believe this intervention is essential for the follow-up care of patients with respiratory conditions after hospital discharge.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nA two-arm, randomized, parallel, controlled clinical trial will be conducted by the University of Salamanca, Spain, in collaboration with the Medical Oncology Service of the University Health Care Complex of Salamanca. The trial aims to recruit 80 oncology patients who exhibit symptoms of dyspnoea during hospital admission. Participants will be randomly assigned to one of two groups: the control group, which will receive a health education program, and the experimental group, which will receive both the health education program and a functional re-education and environmental adaptation program. Assessments will be conducted at three time points: baseline (prior to hospital discharge), follow-up (15 days after discharge), and the end of the intervention (1 month after discharge). During these assessments, sociodemographic data will be collected, and the following scales will be administered: Barthel Index, Medical Research Council Dyspnoea Scale (mMRC), EuroQol 5-D questionnaire (EQ-5D), Visual Analogue Scale (VAS), Short Physical Performance Battery (SPPB), Tampa Scale for Kinesiophobia (TSK), and the Zarit Reduced Caregiver Burden Scale.<\/jats:p>\n<\/jats:sec>\n\nDiscussion<\/jats:title>\nThe findings of this research can be easily implemented in clinical settings by introducing a targeted intervention to improve the quality of life for this patient population. This study aims to advance traditional clinical approaches by facilitating the recovery or adaptation of cancer patients in their daily routines, in relation to the severity of their symptoms. Our primary goal is to enhance independence and functionality, ultimately improving their overall standard of living.<\/jats:p>\n<\/jats:sec>\n\nTrial registration<\/jats:title>\nClinicalTrials.gov; ID: NCT06035263<\/jats:ext-link>. Registered on: September 19, 2023. https:\/\/register.clinicaltrials.gov\/prs\/app\/action\/SelectProtocol?sid=S000DM2U&selectaction=Edit&uid=U0004OJ7&ts=6&cx=f7qqxo<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313207","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T18:35:17Z","timestamp":1736447717000},"page":"e0313207","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8545","authenticated-orcid":true,"given":"Eduardo Jose","family":"Fernandez-Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Rihuete-Galve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Garcia-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Sanchez-Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8407-4127","authenticated-orcid":true,"given":"Fausto Jose","family":"Barbero-Iglesias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Mendez-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Silvia","family":"Puente-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Saez-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Fonseca-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jesus","family":"Cruz-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"pone.0313207.ref001","article-title":"Analyses of quality of life in cancer drug trials: a review of measurements and analytical choices in post-reimbursement studies","volume":"22","author":"BMC Cancer","year":"2022","journal-title":"BMC Cancer"},{"key":"pone.0313207.ref002","first-page":"27","volume-title":"En: Cooper J. Occupational Therapy in Oncology and Palliative Care","author":"J. Cooper","year":"2007","edition":"2"},{"issue":"3)","key":"pone.0313207.ref003","article-title":"The association between having assistive devices and activities of daily living ability and health-related quality of life: an exploratory cross-sectional study among people with advanced cancer","volume":"28","author":"A Funch","year":"2019","journal-title":"Eur J Cancer Care (Engl)"},{"key":"pone.0313207.ref004","unstructured":"American Cancer Society. Learn about vcancer. Retrieved February. [En l\u00ednea] 2011 [Acceso el 25 de noviembre de 2013]. Disponible en: http:\/\/www.cancer.org\/Cancer\/index"},{"issue":"9","key":"pone.0313207.ref005","first-page":"1363","article-title":"In their own words: using the common sense model to analyze patient descriptions of cancer-related fatigue","volume":"28","author":"AM Barsevick","year":"2003","journal-title":"Oncol Nurs Forum"},{"issue":"4","key":"pone.0313207.ref006","first-page":"100","article-title":"Management of patients with advanced cancer","volume":"2","author":"C. Badger","year":"2000","journal-title":"Professional Nurse"},{"key":"pone.0313207.ref007","first-page":"32","article-title":"Occupational therapy in oncology and palliative care","volume":"2","author":"J. Cooper","year":"1997","journal-title":"Whurr"},{"issue":"4","key":"pone.0313207.ref008","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jpsychores.2008.01.002","article-title":"Chronic cancer-related fatigue in long-term survivors of testicular cancer","volume":"64","author":"IJ Orre","year":"2008","journal-title":"J Psychosom Res"},{"key":"pone.0313207.ref009","unstructured":"The American Occupational Therapy Association. The role of occupational therapy in oncology. [En l\u00ednea] 2011 [Acceso el 25 de noviembre de 2013]. Disponible en: http:\/\/www.aota.org\/~\/media\/Corporate\/Files\/AboutOT\/Professionals\/WhatIsOT\/MH\/Facts\/Oncology%20fact%20sheet.ashx"},{"key":"pone.0313207.ref010","first-page":"217","volume-title":"Oncolog\u00eda cl\u00ednica","author":"E Barco","year":"2008","edition":"4"},{"key":"pone.0313207.ref011","unstructured":"National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology: Cancer-related-fatigue. Versi\u00f3n 1.2019 [En l\u00ednea] 2015 [Acceso 7 de junio de 2020]. Disponible en: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/fatigue.pdf"},{"issue":"Suppl 1","key":"pone.0313207.ref012","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1634\/theoncologist.12-S1-4","article-title":"Cancer-related fatigue: the scale of the problem","volume":"12","author":"M Hofman","year":"2007","journal-title":"Oncologist"},{"key":"pone.0313207.ref013","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00520-007-0380-2","article-title":"Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S","volume":"16","author":"DH Henry","year":"2008","journal-title":"Support Care Cancer"},{"key":"pone.0313207.ref014","volume-title":"Cuidados al final de la vida. El duelo. EnOncolog\u00eda cl\u00ednica","author":"F S\u00e1nchez","year":"2012","edition":"4"},{"key":"pone.0313207.ref015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.radonc.2015.12.015","article-title":"Relationship Between Fatigue, Sleep Quality and Inflammatory Cytokines During External Beam Radiation Therapy for Prostate Cancer: A Prospective Study","volume":"118","author":"EB Holiday","year":"2016","journal-title":"Radiother Oncol"},{"key":"pone.0313207.ref016","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1200\/JCO.2007.10.7805","article-title":"Neuroendocirne-immune mechanisms of behavioral comorbidities in patients with cancer","volume":"26","author":"AH Miller","year":"2008","journal-title":"J Clin Oncol"},{"key":"pone.0313207.ref017","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1188\/16.CJON.537-546","article-title":"Genomic variants associated with cancer-related fatigue: a systematic review","volume":"20","author":"JD Tariman","year":"2016","journal-title":"Clin J Oncol Nurs"},{"key":"pone.0313207.ref018","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.6004\/jnccn.2016.0144","article-title":"Dissemination and implementation of guidelines for cancer-related fatigue","volume":"14","author":"AM Berger","year":"2016","journal-title":"J Natl Compr Canc Netw"},{"key":"pone.0313207.ref019","first-page":"Cd008144","article-title":"Educational interventions for the management of cancer-related fatigue in adults","volume":"11","author":"S Bennett","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0313207.ref020","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/cncr.20111","article-title":"A randomized clinical trial of energy conservation for patients with cancer-related fatigue","volume":"100","author":"AM Barsevick","year":"2004","journal-title":"Cancer"},{"key":"pone.0313207.ref021","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/wvn.12352","article-title":"Nonpharmacological interventions for cancer-related fatigue: A systematic review and bayesian network meta-analysis","volume":"16","author":"C Wu","year":"2019","journal-title":"Worlviews Evid Based Nurs"},{"issue":"4","key":"pone.0313207.ref022","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/jcsm.12199","article-title":"Muscle mass as a target to reduce fatigue in patients with advanced cancer","volume":"8","author":"ECW Neefjes","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"9","key":"pone.0313207.ref023","first-page":"2953","article-title":"Effects of resistance exercise in prostate cancer patients: a meta-analysis","volume":"25","author":"M Keilani","year":"2017","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"issue":"6","key":"pone.0313207.ref024","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12529-019-09819-x","article-title":"Association of Body Esteem with Fitness and Body Fat Among Colorectal Cancer Survivors: Secondary Analyses from a Randomized Trial","volume":"26","author":"MM Kindred","year":"2019","journal-title":"Int J Behav Med"},{"issue":"12","key":"pone.0313207.ref025","first-page":"4687","article-title":"Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy","volume":"27","author":"C-J Yen","year":"2019","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"issue":"2","key":"pone.0313207.ref026","first-page":"521","article-title":"Water versus land-based multimodal exercise program effects on body composition in breast cancer survivors: a controlled clinical trial","volume":"21","author":"C Fern\u00e1ndez-Lao","year":"2013","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"issue":"6","key":"pone.0313207.ref027","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3322\/caac.21579","article-title":"Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer","volume":"69","author":"KH Schmitz","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"pone.0313207.ref028","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"KL Campbell","year":"2019","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"pone.0313207.ref029","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/pon.1971","article-title":"Fear of movement in cancer survivors: validation of the modified Tampa scale of kinesiophobia-fatigue","volume":"21","author":"MJ Velthuis","year":"2012","journal-title":"Psychooncology"},{"issue":"10","key":"pone.0313207.ref030","first-page":"1586","article-title":"Kinesiophobia in chronic fatigue syndrome: assessment and associations with disability","volume":"85","author":"J Nijs","year":"2004","journal-title":"Arch Phys Med Rehabil"},{"key":"pone.0313207.ref031","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/pon.4612","article-title":"Predictors of adherence to exercise interventions during and after cancer treatment: a systematic review","volume":"27","author":"HL Ormel","year":"2018","journal-title":"Psychooncology"},{"key":"pone.0313207.ref032","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10549-014-3255-5","article-title":"Taking the next step: a systematic review and meta-analysis of physical activity and behavior change interventions in recent post-treatment breast cancer survivors","volume":"149","author":"SM Bluethmann","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"pone.0313207.ref033","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1037\/hea0000712","article-title":"Promoting physical activity among c\u00e1ncer survivors: meta-analysis and meta-CART analysis of randomized controlled trials","volume":"38","author":"P Sheeran","year":"2019","journal-title":"Health Psychol"},{"key":"pone.0313207.ref034","first-page":"9","article-title":"Interventions for promoting habitual exercise in people living with and beyond cancer","author":"RR Turner","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0313207.ref035","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.pec.2017.01.019","article-title":"Physical activity levels and barriers to exercise referral among patients with cancer","volume":"100","author":"DD Yang","year":"2017","journal-title":"Patient Educ Couns"},{"key":"pone.0313207.ref036","first-page":"61","article-title":"Functional Evaluation: The Barthel Index","volume":"14","author":"FI Mahoney","year":"1965","journal-title":"Md State Med J"},{"issue":"3","key":"pone.0313207.ref037","first-page":"13","article-title":"The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue","volume":"34","author":"D. Cella","year":"1997","journal-title":"Semin Hematol"},{"key":"pone.0313207.ref038","volume-title":"Trail Making Test: Manual for administration and scoring","author":"RM Reitan","year":"1992"},{"key":"pone.0313207.ref039","first-page":"311","article-title":"Using the EuroQoI 5-D in the Catalan general population: feasibility and construct validity","volume":"7","author":"X Badia","year":"1998","journal-title":"Qual life Res an Int J Qual life Asp Treat care Rehabil"},{"key":"pone.0313207.ref040","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0196-0644(96)70223-8","article-title":"Review of pain-measurement tools","volume":"27","author":"K Ho","year":"1996","journal-title":"Ann Emerg Med"},{"key":"pone.0313207.ref041","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3959(97)00005-5","article-title":"The visual analogue pain intensity scale: what is moderate pain in millimetres?","volume":"72","author":"SL Collins","year":"1997","journal-title":"Pain"},{"key":"pone.0313207.ref042","first-page":"145","article-title":"Assessment with Short Physical Performance Battery Scale of Functional Ability in the Elderly over 70 years","volume":"24","author":"F Martinez-Monje","year":"2017","journal-title":"Atenci\u00f3n Fam"},{"key":"pone.0313207.ref043","article-title":"Effectiveness of educational program on quality of life of fatigue reported by the oncologic disease","author":"MI Rihuete Galve","year":"2018","journal-title":"Fundaci\u00f3n Index"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T18:35:30Z","timestamp":1736447730000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313207"}},"subtitle":[],"editor":[{"given":"Robert Jeenchen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313207","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]}}}