{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:31:19Z","timestamp":1787923879674,"version":"build-2784847793"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This proposed scoping review aims to examine studies assessing the impact of drug shortages on population-level drug utilization trends. The objectives of this review are to a) assess which drugs have been studied and describe associated drug characteristics, b) determine jurisdictions and healthcare settings that have conducted these studies, and c) describe how changes in drug use and the extent of shortage impacts are reported in literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Drug shortages continue to impair drug access and delivery of quality care across the world. However, the impact of drug supply disruptions on availability and drug use are understudied in current literature. This proposed scoping review will identify this gap and inform future research initiatives aimed at determining the real-world impacts of drug shortages.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Inclusion criteria<\/jats:title>\n<jats:p>Published and unpublished observational studies reporting on the effects of drug supply chain disruptions (shortages, discontinuations, and safety-based withdrawals) on consequent utilization trends faced by pharmaceutical products (i.e. prescription drugs, over-the-counter drugs, vaccines, therapy products, pharmaceutical solutions). Literature reviews, meta-analyses, randomized control trials, case series, case reports, and opinion pieces will be excluded.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The search strategy will combine two key search concepts: drug shortages and drug utilization. The search will be conducted in MEDLINE and EMBASE. This will be followed by an extensive grey literature search in grey literature databases, targeted websites and Google. Furthermore, reference lists of included articles will be searched. Articles will be independently screened, selected and extracted by two reviewers. Data will be descriptively analyzed and presented in tables.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p><jats:bold>Review registration number<\/jats:bold>: Open Science Framework, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/osf.io\/2p6e5\" xlink:type=\"simple\">https:\/\/osf.io\/2p6e5<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313298","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T17:28:47Z","timestamp":1730482127000},"page":"e0313298","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of supply chain disruptions and drug shortages on drug utilization: A scoping review protocol"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-8557","authenticated-orcid":true,"given":"Araniy","family":"Santhireswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5160-0776","authenticated-orcid":true,"given":"Martin","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-2083","authenticated-orcid":true,"given":"Etienne","family":"Gaudette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Burry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Tadrous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"issue":"23","key":"pone.0313298.ref001","doi-asserted-by":"crossref","first-page":"E801","DOI":"10.1503\/cmaj.212070","article-title":"COVID-19 and the prevalence of drug shortages in Canada: a cross-sectional time-series analysis from April 2017 to April 2022.","volume":"194","author":"B Lau","year":"2022","journal-title":"Cmaj"},{"key":"pone.0313298.ref002","volume-title":"Meeting Report: Technical Definitions of Shortages and Stockouts of Medicines and Vaccines.","author":"World Health Organization","year":"2016"},{"key":"pone.0313298.ref003","first-page":"2022","article-title":"Drug Shortages","author":"US Food and Drug Administration"},{"issue":"4","key":"pone.0313298.ref004","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/1715163520929387","article-title":"Role of Canadian pharmacists in managing drug shortage concerns amid the COVID-19 pandemic.","volume":"153","author":"A Elbeddini","year":"2020","journal-title":"Can Pharm J (Ott)."},{"issue":"5","key":"pone.0313298.ref005","doi-asserted-by":"crossref","first-page":"e0215837","DOI":"10.1371\/journal.pone.0215837","article-title":"The impacts of medication shortages on patient outcomes: A scoping review.","volume":"14","author":"JM Phuong","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"pone.0313298.ref006","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40273-013-0116-8","article-title":"Clinical and economic impact of substituting dexmedetomidine for propofol due to a US drug shortage: examination of coronary artery bypass graft patients at an urban medical centre","volume":"32","author":"BN Thoma","year":"2014","journal-title":"Pharmacoeconomics"},{"issue":"12","key":"pone.0313298.ref007","doi-asserted-by":"crossref","first-page":"e0293497","DOI":"10.1371\/journal.pone.0293497","article-title":"Early observations of Tier-3 drug shortages on purchasing trends across Canada: A cross-sectional analysis of 3 case-example drugs.","volume":"18","author":"A Santhireswaran","year":"2023","journal-title":"PLoS One"},{"key":"pone.0313298.ref008","author":"S Chapman","year":"2022","journal-title":"Shortages of medicines in OECD countries"},{"key":"pone.0313298.ref009","article-title":"Drug Shortages","author":"Canadian Pharmacists Association","year":"2020"},{"issue":"4","key":"pone.0313298.ref010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1310\/hpj5004-279","article-title":"Impact of Drug Shortages on Health System Pharmacies in the Southeastern United States.","volume":"50","author":"CR Caulder","year":"2015","journal-title":"Hosp Pharm."},{"issue":"3","key":"pone.0313298.ref011","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/ajhp\/60.3.245","article-title":"Managing drug shortages: seven years\u2019 experience at one health system.","volume":"60","author":"ER Fox","year":"2003","journal-title":"Am J Health Syst Pharm"},{"issue":"1","key":"pone.0313298.ref012","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12913-017-2385-y","article-title":"Parents\u2019 and guardians\u2019 perceptions on availability and pricing of medicines and healthcare for children in eThekwini, South Africa\u2014a qualitative study.","volume":"17","author":"VA Perumal-Pillay","year":"2017","journal-title":"BMC Health Serv Res"},{"issue":"5","key":"pone.0313298.ref013","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s11096-016-0342-1","article-title":"Medicine shortages in Australia: causes, impact and management strategies in the community setting.","volume":"38","author":"YX Tan","year":"2016","journal-title":"Int J Clin Pharm"},{"issue":"14","key":"pone.0313298.ref014","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2017.2841","article-title":"Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock","volume":"317","author":"E 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Providing a formal definition of scoping reviews as a type of evidence synthesis.","volume":"20","author":"Z Munn","year":"2022","journal-title":"JBI Evid Synth"},{"issue":"1","key":"pone.0313298.ref019","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping Studies: Towards a Methodological Framework.","volume":"8","author":"H Arksey","year":"2005","journal-title":"International Journal of Social Research Methodology"},{"key":"pone.0313298.ref020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: advancing the methodology.","volume":"5","author":"D Levac","year":"2010","journal-title":"Implement Sci"},{"key":"pone.0313298.ref021","volume-title":"In: JBI Manual for Evidence Synthesis [Internet]","author":"M Peters","year":"2020"},{"issue":"7","key":"pone.0313298.ref022","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation.","volume":"169","author":"AC Tricco","year":"2018","journal-title":"Ann Intern Med"},{"issue":"3","key":"pone.0313298.ref023","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3163\/1536-5050.104.3.014","article-title":"De-duplication of database search results for systematic reviews in EndNote.","volume":"104","author":"WM Bramer","year":"2016","journal-title":"J Med Libr Assoc"},{"issue":"3","key":"pone.0313298.ref024","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic.","volume":"22","author":"ML McHugh","year":"2012","journal-title":"Biochem Med (Zagreb)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T17:28:59Z","timestamp":1730482139000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313298"}},"subtitle":[],"editor":[{"given":"Udoka","family":"Okpalauwaekwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313298","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,1]]}}}