{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:13:22Z","timestamp":1782832402751,"version":"3.54.5"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are the most common types of inflammatory musculoskeletal disorders that share overlapping clinical features and complications. The aim of this study was to identify shared marker genes and mechanistic similarities between PsA and RA.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We utilized datasets from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) and perform functional enrichment analyses. To identify the marker genes, we applied two machine learning algorithms: the least absolute shrinkage and selection operator (LASSO) and the support vector machine recursive feature elimination (SVM-RFE). Subsequently, we assessed the diagnostic capacity of the identified marker genes using the receiver operating characteristic (ROC) curve and decision curve analysis (DCA). A transcription factor (TF) network was constructed using data from JASPAR, HumanTFDB, and GTRD. We then employed CIBERSORT to analyze the abundance of immune infiltrates in PsA and RA, assessing the relationship between marker genes and immune cells. Additionally, cellular subpopulations were identified by analyzing single-cell sequencing data from RA, with T cells examined for trajectory and cellular communication using Monocle and CellChat, thereby exploring their linkage to marker genes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of seven overlapping DEGs were identified between PsA and RA. Gene enrichment analysis revealed that these genes were associated with mitochondrial respiratory chain complex IV, Toll-like receptors, and NF-\u03baB signaling pathways. Both machine learning algorithms identified Ribosomal Protein L22-like 1 (RPL22L1) and Lymphocyte Antigen 96 (LY96) as potential diagnostic markers for PsA and RA. These markers were validated using test sets and experimental approaches. Furthermore, GSEA analysis indicated that gap junctions may play a crucial role in the pathogenesis of both conditions. The TF network suggested a potential association between marker genes and core enrichment genes related to gap junctions. The application of CIBERSORT and single-cell RNA sequencing provided a comprehensive understanding of the role of marker genes in immune cell function. Our results indicated that RPL22L1 and LY96 are involved in T cell development and are associated with T cell communication with NK cells and monocytes. Notably, high expression of both RPL22L1 and LY96 was linked to enhanced VEGF signaling in T cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our study identified RPL22L1 and LY96 as key biomarkers for PsA and RA. Further investigations demonstrated that these two marker genes are closely associated with gap junction function, T cell infiltration, differentiation, and VEGF signaling. Collectively, these findings provide new insights into the diagnosis and treatment of PsA and RA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313344","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T18:32:50Z","timestamp":1731004370000},"page":"e0313344","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["The shared biomarkers and immune landscape in psoriatic arthritis and rheumatoid arthritis: Findings based on bioinformatics, machine learning and single-cell analysis"],"prefix":"10.1371","volume":"19","author":[{"given":"Kaiyi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-7542","authenticated-orcid":true,"given":"Sheng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"issue":"Suppl 2","key":"pone.0313344.ref001","first-page":"ii14","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"DD Gladman","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"pone.0313344.ref002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1468-3083.2009.03565.x","article-title":"Assessment of risk of psoriatic arthritis in patients with plaque psoriasis: a systematic review of the literature","volume":"24","author":"S Prey","year":"2010","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"5","key":"pone.0313344.ref003","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.autrev.2012.10.002","article-title":"Immunomodulation in psoriatic arthritis: focus on cellular and molecular pathways.","volume":"12","author":"MS Chimenti","year":"2013","journal-title":"Autoimmun Rev"},{"issue":"10","key":"pone.0313344.ref004","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic Arthritis","volume":"376","author":"CT Ritchlin","year":"2017","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"pone.0313344.ref005","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"AJ Silman","year":"2002","journal-title":"Arthritis Res"},{"key":"pone.0313344.ref006","author":"G Sucilathangam","year":"2015","journal-title":"Use of Serological markers for evaluation of patients with Rheumatoid arthritis"},{"issue":"1","key":"pone.0313344.ref007","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clim.2015.04.005","article-title":"Biomarkers for rheumatoid and psoriatic arthritis","volume":"161","author":"MK Verheul","year":"2015","journal-title":"Clin Immunol"},{"issue":"10136","key":"pone.0313344.ref008","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"DJ Veale","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"pone.0313344.ref009","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"CM Weyand","year":"2021","journal-title":"Nat Immunol"},{"key":"pone.0313344.ref010","doi-asserted-by":"crossref","first-page":"737079","DOI":"10.3389\/fmed.2021.737079","article-title":"Extra-Articular Manifestations and Comorbidities in Psoriatic Disease: A Journey Into the Immunologic Crosstalk.","volume":"8","author":"L Novelli","year":"2021","journal-title":"Front Med (Lausanne)."},{"issue":"11","key":"pone.0313344.ref011","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1136\/annrheumdis-2017-211284","article-title":"Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study","volume":"76","author":"B Michelsen","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"pone.0313344.ref012","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaad.2004.07.023","article-title":"Rheumatoid arthritis: a review of the cutaneous manifestations","volume":"53","author":"A Sayah","year":"2005","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"pone.0313344.ref013","doi-asserted-by":"crossref","first-page":"102776","DOI":"10.1016\/j.autrev.2021.102776","article-title":"Rheumatoid arthritis: Extra-articular manifestations and comorbidities.","volume":"20","author":"FA Figus","year":"2021","journal-title":"Autoimmun Rev."},{"issue":"1","key":"pone.0313344.ref014","first-page":"58","article-title":"Serum amyloid A in the assessment of early inflammatory arthritis","volume":"27","author":"G Cunnane","year":"2000","journal-title":"J Rheumatol"},{"issue":"11","key":"pone.0313344.ref015","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/rheumatology\/keg385","article-title":"Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis.","volume":"42","author":"D Foell","year":"2003","journal-title":"Rheumatology (Oxford)."},{"issue":"1","key":"pone.0313344.ref016","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/00365510410003732","article-title":"Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritis","volume":"64","author":"B Gudbj\u00f6rnsson","year":"2004","journal-title":"Scand J Clin Lab Invest"},{"issue":"3","key":"pone.0313344.ref017","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1189\/jlb.2A0317-115RR","article-title":"Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages","volume":"102","author":"MW Tang","year":"2017","journal-title":"J Leukoc Biol"},{"issue":"2","key":"pone.0313344.ref018","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/cei.12449","article-title":"Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different contribution to systemic and joint inflammation","volume":"179","author":"R Scrivo","year":"2015","journal-title":"Clin Exp Immunol"},{"issue":"19","key":"pone.0313344.ref019","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/bioinformatics\/btu375","article-title":"Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction","volume":"30","author":"HS Parker","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0313344.ref020","first-page":"1","volume":"33","author":"J Friedman","year":"2010","journal-title":"Regularization Paths for Generalized Linear Models via Coordinate Descent"},{"issue":"6","key":"pone.0313344.ref021","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection.","volume":"1","author":"A Liberzon","year":"2015","journal-title":"Cell Syst"},{"issue":"11","key":"pone.0313344.ref022","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"pone.0313344.ref023","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks.","volume":"127","author":"Y Tang","year":"2015","journal-title":"Biosystems."},{"issue":"5","key":"pone.0313344.ref024","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nat Methods"},{"key":"pone.0313344.ref025","doi-asserted-by":"crossref","first-page":"878226","DOI":"10.3389\/fimmu.2022.878226","article-title":"Single-Cell RNA and ATAC Sequencing Reveal Hemodialysis-Related Immune Dysregulation of Circulating Immune Cell Subpopulations.","volume":"13","author":"H Wu","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"pone.0313344.ref026","doi-asserted-by":"crossref","first-page":"e20211191","DOI":"10.1084\/jem.20211191","article-title":"CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases","volume":"219","author":"B Zhang","year":"2022","journal-title":"J Exp Med"},{"issue":"1","key":"pone.0313344.ref027","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat.","volume":"12","author":"S Jin","year":"2021","journal-title":"Nat Commun."},{"issue":"1","key":"pone.0313344.ref028","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/art.41899","article-title":"Identification and Evaluation of Serum Protein Biomarkers That Differentiate Psoriatic Arthritis From Rheumatoid Arthritis.","volume":"74","author":"A Mc Ardle","year":"2022","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"pone.0313344.ref029","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/annrheumdis-2019-216374","article-title":"Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis","volume":"79","author":"M Souto-Carneiro","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"pone.0313344.ref030","doi-asserted-by":"crossref","first-page":"812996","DOI":"10.3389\/fimmu.2022.812996","article-title":"Altered Fecal Metabolomics and Potential Biomarkers of Psoriatic Arthritis Differing From Rheumatoid Arthritis.","volume":"13","author":"N Wang","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"pone.0313344.ref031","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","article-title":"Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.","volume":"12","author":"U Fearon","year":"2016","journal-title":"Nat Rev Rheumatol.Jul"},{"issue":"6","key":"pone.0313344.ref032","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1089\/ars.2009.2607","article-title":"Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention.","volume":"12","author":"DC Phillips","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"pone.0313344.ref033","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/jhg.2015.50","article-title":"Aggregation of rare\/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients","volume":"60","author":"S Mitsunaga","year":"2015","journal-title":"J Hum Genet"},{"issue":"6","key":"pone.0313344.ref034","first-page":"467","article-title":"Evaluation of oxidative stress in rheumatoid and psoriatic arthritis and psoriasis.","volume":"160","author":"S Coaccioli","year":"2009","journal-title":"Clin Ter."},{"key":"pone.0313344.ref035","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fphys.2017.00600","article-title":"Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies.","volume":"8","author":"X Yang","year":"2017","journal-title":"Front Physiol"},{"issue":"3","key":"pone.0313344.ref036","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/jcla.20243","article-title":"Protein oxidation markers in the serum and synovial fluid of psoriatic arthritis patients.","volume":"22","author":"O Firuzi","year":"2008","journal-title":"J Clin Lab Anal"},{"issue":"23","key":"pone.0313344.ref037","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1016\/j.febslet.2011.04.028","article-title":"Radstake TRDJ. Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?","volume":"585","author":"KCM Santegoets","year":"2011","journal-title":"FEBS Lett"},{"issue":"2","key":"pone.0313344.ref038","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000260417","article-title":"The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn\u2019s disease and ulcerative colitis: a meta-analysis","volume":"81","author":"X Shen","year":"2010","journal-title":"Digestion"},{"issue":"3","key":"pone.0313344.ref039","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00403-016-1620-4","article-title":"Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis.","volume":"308","author":"RL Smith","year":"2016","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"pone.0313344.ref040","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00439-011-0962-4","article-title":"Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the Atherosclerosis Risk in Communities MRI Study","volume":"129","author":"SJ Bielinski","year":"2011","journal-title":"Hum Genet"},{"issue":"6","key":"pone.0313344.ref041","first-page":"958","article-title":"Toll-like receptor (TLR) 2 is upregulated on peripheral blood monocytes of patients with psoriatic arthritis: a role for a gram-positive inflammatory trigger?","volume":"29","author":"S Carrasco","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"pone.0313344.ref042","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2007.05.024","article-title":"Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin","volume":"27","author":"B Rebholz","year":"2007","journal-title":"Immunity"},{"issue":"6","key":"pone.0313344.ref043","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI200316069","article-title":"Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis","volume":"111","author":"CT Ritchlin","year":"2003","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0313344.ref044","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","article-title":"TRANCE\/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis","volume":"159","author":"AR Pettit","year":"2001","journal-title":"Am J Pathol"},{"issue":"7","key":"pone.0313344.ref045","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/ijms20071599","article-title":"NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases.","volume":"20","author":"A Fiordelisi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"pone.0313344.ref046","doi-asserted-by":"crossref","first-page":"108397","DOI":"10.1016\/j.clim.2020.108397","article-title":"Comorbidities associated with psoriatic arthritis: Review and update","volume":"214","author":"LM Perez-Chada","year":"2020","journal-title":"Clin Immunol"},{"issue":"1","key":"pone.0313344.ref047","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41420-022-01153-8","article-title":"Ribosomal protein L22-like1 (RPL22L1) mediates sorafenib sensitivity via ERK in hepatocellular carcinoma.","volume":"8","author":"D Zhang","year":"2022","journal-title":"Cell Death Discov"},{"issue":"12","key":"pone.0313344.ref048","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1073\/pnas.0306906101","article-title":"Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations","volume":"101","author":"TL Gioannini","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0313344.ref049","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrrheum.2017.204","article-title":"Joint diseases: from connexins to gap junctions.","volume":"14","author":"HJ Donahue","year":"2017","journal-title":"Nat Rev Rheumatol."},{"issue":"4","key":"pone.0313344.ref050","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jor.22263","article-title":"Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis","volume":"31","author":"S Tsuchida","year":"2013","journal-title":"J Orthop Res"},{"issue":"1\u20132","key":"pone.0313344.ref051","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pbiomolbio.2007.03.008","article-title":"Gap junction-mediated intercellular communication in the immune system","volume":"94","author":"J Neijssen","year":"2007","journal-title":"Prog Biophys Mol Biol"},{"issue":"1","key":"pone.0313344.ref052","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2009.10.005","article-title":"Expression of MDC\/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"49","author":"HA Flytlie","year":"2010","journal-title":"Cytokine"},{"issue":"4","key":"pone.0313344.ref053","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/ard.60.4.316","article-title":"Immunohistological study of entheses in spondyloarthropathies: comparison in rheumatoid arthritis and osteoarthritis","volume":"60","author":"L Laloux","year":"2001","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"pone.0313344.ref054","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/rheumatology\/kel229","article-title":"Increased expression of CD154 (CD40L) on stimulated T-cells from patients with psoriatic arthritis.","volume":"46","author":"D Daoussis","year":"2007","journal-title":"Rheumatology (Oxford)."},{"key":"pone.0313344.ref055","doi-asserted-by":"crossref","first-page":"108425","DOI":"10.1016\/j.clim.2020.108425","article-title":"Traitor or warrior-Treg cells sneaking into the lesions of psoriatic arthritis","volume":"215","author":"Y Liu","year":"2020","journal-title":"Clin Immunol"},{"key":"pone.0313344.ref056","doi-asserted-by":"crossref","first-page":"626193","DOI":"10.3389\/fimmu.2021.626193","article-title":"Function and Role of Regulatory T Cells in Rheumatoid Arthritis.","volume":"12","author":"Q Jiang","year":"2021","journal-title":"Front Immunol."},{"issue":"3","key":"pone.0313344.ref057","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molmed.2018.12.008","article-title":"Neutrophils in Rheumatoid Arthritis: Breaking Immune Tolerance and Fueling Disease","volume":"25","author":"LJ O\u2019Neil","year":"2019","journal-title":"Trends Mol Med"},{"issue":"4","key":"pone.0313344.ref058","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.devcel.2013.01.018","article-title":"Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs","volume":"24","author":"Y Zhang","year":"2013","journal-title":"Dev Cell"},{"issue":"4","key":"pone.0313344.ref059","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4049\/jimmunol.2100668","article-title":"Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis","volume":"208","author":"SP Fahl","year":"2022","journal-title":"J Immunol"},{"issue":"2","key":"pone.0313344.ref060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000516642","article-title":"T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38.","volume":"14","author":"H Wang","year":"2022","journal-title":"J Innate Immun."},{"key":"pone.0313344.ref061","doi-asserted-by":"crossref","first-page":"655477","DOI":"10.3389\/fimmu.2021.655477","article-title":"A Tale of Two Immune Cells in Rheumatoid Arthritis: The Crosstalk Between Macrophages and T Cells in the Synovium.","volume":"12","author":"J Tu","year":"2021","journal-title":"Front Immunol."},{"issue":"16","key":"pone.0313344.ref062","doi-asserted-by":"crossref","first-page":"e176586","DOI":"10.1172\/JCI176586","article-title":"Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses","volume":"134","author":"J He","year":"2024","journal-title":"J Clin Invest"},{"issue":"1","key":"pone.0313344.ref063","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s41065-021-00201-0","article-title":"Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis","volume":"158","author":"Y Ge","year":"2021","journal-title":"Hereditas"},{"key":"pone.0313344.ref064","doi-asserted-by":"crossref","first-page":"836533","DOI":"10.3389\/fimmu.2022.836533","article-title":"Osteoarticular Involvement-Associated Biomarkers and Pathways in Psoriasis: The Shared Pathway With Ankylosing Spondylitis.","volume":"13","author":"YP Zhang","year":"2022","journal-title":"Front Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T18:33:08Z","timestamp":1731004388000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0313344"}},"subtitle":[],"editor":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":64,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0313344","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}