{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:26:24Z","timestamp":1789539984879,"version":"build-2803163510"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Despite significant advancements in HIV treatment, virological outcomes remain a critical issue. Ethiopia did not meet the 90:90:90 targets set for 2020, which aimed for 90% of people on antiretroviral therapy to achieve viral suppression. As the country shifts its focus toward the 95:95:95 targets for 2030\u2014seeking to achieve 95% viral suppression among those on ART\u2014it is crucial to deepen our understanding of viral suppression and the factors that influence it.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Virological suppression was examined among 410 HIV-positive individuals on ART using the EPHIA survey. The survey employed a two-stage, stratified sampling design across urban areas in nine regions and two city administrations. Data analysis was conducted with STATA version 18, and multicollinearity was assessed using variance inflation factors. A logistic regression model identified significant determinants of viral suppression, with variables having a p-value of \u22640.05 considered statistically significant in the multivariable analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The findings revealed that 364 participants (88.78%) achieved viral suppression. Key determinants of virological outcomes included a higher wealth level (AOR = 2.67, 95% CI: 1.15\u20136.22), the presence of active TB (AOR = 0.27, 95% CI: 0.14\u20130.57), hepatitis B virus (AOR = 0.20, 95% CI: 0.10\u20130.31), and the utilization of HIV support group care (AOR = 3.14, 95% CI: 1.35\u20136.30).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Viral suppression among HIV patients is 88.78%, which even falls short of the WHO\u2019s 90% target for 2020, indicating the substantial work required to achieve 95% by 2030. To improve virological outcomes, it is crucial to increase support for low-income patients, enhance management of co-infections like TB and hepatitis B, and expand access to HIV support groups for better adherence and care.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313481","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:21:03Z","timestamp":1735845663000},"page":"e0313481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Virological outcomes of antiretroviral therapy and its determinants among HIV patients in Ethiopia: Implications for achieving the 95\u201395\u201395 target"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-1249","authenticated-orcid":true,"given":"Tegene Atamenta","family":"Kitaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ribka Nigatu","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"pone.0313481.ref001","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-0716-2463-0_522","volume-title":"Infectious Diseases","author":"PJ Kanki","year":"2023"},{"key":"pone.0313481.ref002","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/HIV.S354716","article-title":"Virological and immunological antiretroviral treatment failure and predictors among HIV positive adult and adolescent clients in southeast Ethiopia.","author":"A Mamo","year":"2022","journal-title":"HIV\/AIDS-Research and Palliative Care."},{"key":"pone.0313481.ref003","author":"D. 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Chipanta","year":"2022","journal-title":"EClinicalMedicine"},{"key":"pone.0313481.ref028","first-page":"1","article-title":"Socio-Behavioural Barriers to Viral Suppression in the Older Adult Population in Rural South Africa","author":"C Chinogurei","year":"2024","journal-title":"AIDS and Behavior"},{"issue":"12","key":"pone.0313481.ref029","doi-asserted-by":"crossref","first-page":"e0168687","DOI":"10.1371\/journal.pone.0168687","article-title":"Impact of socioeconomic inequality on access, adherence, and outcomes of antiretroviral treatment services for people living with HIV\/AIDS in Vietnam.","volume":"11","author":"BX Tran","year":"2016","journal-title":"PLoS One"},{"key":"pone.0313481.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2428-3","article-title":"Factors associated with virological non-suppression among HIV-positive patients on antiretroviral therapy in Uganda, August 2014\u2013July 2015.","volume":"17","author":"L Bulage","year":"2017","journal-title":"BMC infectious diseases."},{"key":"pone.0313481.ref031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-019-4732-6","article-title":"HIV virological non-suppression and factors associated with non-suppression among adolescents and adults on antiretroviral therapy in northern Ethiopia: a retrospective study.","volume":"20","author":"AA Desta","year":"2020","journal-title":"BMC infectious diseases."},{"issue":"7","key":"pone.0313481.ref032","doi-asserted-by":"crossref","first-page":"e68152","DOI":"10.1371\/journal.pone.0068152","article-title":"Suppression of HBV by tenofovir in HBV\/HIV coinfected patients: a systematic review and meta-analysis.","volume":"8","author":"H Price","year":"2013","journal-title":"PloS one."},{"issue":"1","key":"pone.0313481.ref033","article-title":"Influence of hepatitis B virus co-infection on virological and immunological response to antiretroviral treatment among HIV patients attending 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