{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:42:37Z","timestamp":1771332157156,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["24IVPHA1297559 https:\/\/doi.org\/10.58275\/AHA.24IVPHA1297559.pc.gr.193866 (SKM)."],"award-info":[{"award-number":["24IVPHA1297559 https:\/\/doi.org\/10.58275\/AHA.24IVPHA1297559.pc.gr.193866 (SKM)."]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hypertension is a risk factor for cardiovascular events. Inflammation plays an important role in the development of essential hypertension. Studies assessing the association between complete blood count-based inflammatory scores (CBCIS) and hypertension are scarce. Therefore, this study aimed to determine the relationship between CBCIS and hypertension among individuals with and without human immunodeficiency virus (HIV).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>This was a cross-sectional study among 344 participants at Serenje District Hospital and Serenje Urban Clinic. We used structured questionnaires to collect sociodemographic, clinical and laboratory characteristics. CBCIS included lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), derived neutrophil-lymphocyte ratio (d-NLR), and differential white blood cells. The primary outcome variable was hypertension defined as systolic and diastolic blood pressure higher than or equal to 140\/90 mmHg. Logistic regression was used to estimate the association between hypertension and CBCIS in statistical package for social science (SPSS) version 22.0.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The participants had a median age of 32 years (interquartile range (IQR) 24\u201342) and 65.1% (n = 224) were female. The prevalence of hypertension was 10.5% (n = 36). Among those with hypertension, 55.6% (n = 20) were female and 44.4% (n = 16) were male. The CBCIS significantly associated with hypertension in people living with HIV (PLWH) was PLR (adjusted odds ratio (AOR) 0.98; 95% confidence interval (CI) 0.97\u20130.99, p = 0.01) while in people without HIV, AMC (AOR 15.40 95%CI 3.75\u201363.26), ANC (AOR 1.88 95%CI 1.05\u20133.36), WBC (AOR 0.52 95%CI 0.31\u20130.87) and PLR (AOR 0.98 95%CI 0.97\u20130.99) were the factors associated with hypertension. Compared to people without HIV, only WBC, ANC, NLR, and d-NLR were good predictors of hypertension among PLWH.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our study indicates a notable HIV-status driven association between CBCIS and hypertension, suggesting the use of CBICS as potential biomarkers for hypertension risk with substantial implications for early detection and preventive measures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313484","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T18:29:58Z","timestamp":1731349798000},"page":"e0313484","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between complete blood-count-based inflammatory scores and hypertension in persons living with and without HIV in Zambia"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8989-6856","authenticated-orcid":true,"given":"Lackson","family":"Mwape","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benson M.","family":"Hamooya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-2422","authenticated-orcid":true,"given":"Emmanuel L.","family":"Luwaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Muzata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1924-6819","authenticated-orcid":true,"given":"Kaole","family":"Bwalya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chileleko","family":"Siakabanze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agness","family":"Mushabati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepiso K.","family":"Masenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"pone.0313484.ref001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1755-7682-4-34","article-title":"Prevalence of hypertension and its correlates in Lusaka urban district of Zambia: a population based survey","volume":"4","author":"FM Goma","year":"2011","journal-title":"Int Arch Med"},{"key":"pone.0313484.ref002","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cophys.2020.09.016","article-title":"The role of inflammation in hypertension: novel concepts","volume":"19","author":"DM Patrick","year":"2021","journal-title":"Curr Opin Physiol"},{"key":"pone.0313484.ref003","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41581-021-00430-6","article-title":"Hypertension-induced cognitive impairment: from pathophysiology to public 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