{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:10:16Z","timestamp":1740147016697,"version":"3.37.3"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/13378-8"],"award-info":[{"award-number":["2021\/13378-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/01387-0"],"award-info":[{"award-number":["2020\/01387-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309701\/2022-8"],"award-info":[{"award-number":["309701\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/09633-0"],"award-info":[{"award-number":["2020\/09633-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Submitting late-term pregnant mares to anesthesia for non-obstetric surgery raises concerns about the survival of the mother and fetus. This study aimed to evaluate and describe transient maternal and fetal hemodynamic changes during general inhalation anesthesia in mares during the last month of gestation. Nine adult mares in the last month of gestation were subjected to general inhalation anesthesia and dorsal recumbency for 90 minutes. Trans-anesthetic vital parameters, arterial hemogasometry, cardiac output, pulmonary arterial pressure, central venous pressure, and fetal heart rates were assessed at defined intervals. During various timespans of the anesthetic procedure, the mares demonstrated an increase in heart rate, mean arterial pressure, and diastolic pressure as well as a decrease in temperature. Additionally, arterial hemogasometry indicated respiratory acidosis. No changes in cardiac output were observed; however, there was a reduction in pulmonary arterial and central venous pressures and stroke volume. Fetal heart rate was significantly decreased. General inhalation anesthesia in late term pregnancy in mares in a recumbent position implies in significant hemodynamic and metabolic changes. Up to 90 minutes those changes does not seem to affect negatively the maternal-fetus prognosis.<\/jats:p>","DOI":"10.1371\/journal.pone.0313563","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T18:32:36Z","timestamp":1732300356000},"page":"e0313563","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anesthesia for non-obstetric surgery during late term pregnancy in mares"],"prefix":"10.1371","volume":"19","author":[{"given":"Pedro Henrique Salles","family":"Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-134X","authenticated-orcid":true,"given":"Mar\u00edlia Alves","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elidiane","family":"Rusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia de Assis","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Bonfim","family":"Carregaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Augusto Ara\u00fajo","family":"Valad\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana Fumes","family":"Ghantous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-0358","authenticated-orcid":true,"given":"Renata Gebara Sampaio","family":"D\u00f3ria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"pone.0313563.ref001","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.2042-3306.1993.tb03004.x","article-title":"Review of 115 cases of colic in the pregnant mare","volume":"25","author":"KJ Boening","year":"1993","journal-title":"Equine Veterinary Journal"},{"key":"pone.0313563.ref002","first-page":"481","article-title":"Foaling rates and risk factors for abortion in pregnant mares presented for medical or surgical treatment of colic: 153 cases (1993\u20132005).","volume":"50","author":"TS Chenier","year":"2009","journal-title":"The Canadian Veterinary Journal"},{"key":"pone.0313563.ref003","first-page":"346","article-title":"Factors influencing foaling rate following colic surgery in pregnant Thoroughbred mares in Central Kentucky","volume":"201245","author":"J Drumm N","year":"2012","journal-title":"Equine Veterinary Journal"},{"key":"pone.0313563.ref004","first-page":"60","article-title":"Anaesthesia for non-obstetric surgery during pregnancy","author":"M Upadya","year":"2016","journal-title":"Indian Journal of Anaesthesia"},{"key":"pone.0313563.ref005","first-page":"S79","article-title":"Anesthesia for nonobstetric surgery during pregnancy.","volume":"19","author":"WWV Boas","year":"2009","journal-title":"Revista M\u00e9dica de Minas Gerais"},{"key":"pone.0313563.ref006","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cveq.2012.11.002","article-title":"Cardiac output monitoring in horses.","volume":"29","author":"A. 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