{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:30:31Z","timestamp":1736400631807,"version":"3.32.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stifelsen Dam and landsforeningen uventet barned\u00f8d","award":["2022\/FO387075"],"award-info":[{"award-number":["2022\/FO387075"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Studies have reported that pregnancies conceived by fathers with modifiable cardiovascular risk factors are at higher risk of ending in losses compared to those without such risk factors. Our objective was to examine the association between paternal family history _a non-modifiable risk factor_ of premature atherosclerotic disease and perinatal death.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This is a population-based cohort study. Information on fathers, aged 18\u201350 years who participated in three population-based health surveys conducted in Norway during 1974\u20132003 was linked to their singleton births registered in the Medical Birth Registry of Norway. We used multilevel mixed effect logistic regression analyses with random intercepts by father\u2019s identification number. The birth was the observation unit in all analyses.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 220,386 fathers who had 512,111 births with information on family history of CHD (12.3% with positive family history) and 203,257 births with information on family history of stroke (9.2% with positive family history) were analysed. There were 782 (1.3%) and 195 (1%) perinatal deaths in births to fathers with family history of CHD and stroke while 5,922 (1.3%) and 1,858 (1%) in those without family histories. We found no association between family history of CHD and stillbirth (OR 1.01, 95% CI 0.92; 1.12), neonatal death (OR 0.98, 95%CI 0.86, 1.11) or perinatal death (OR 1.00, 95% CI 0.92, 1.08). Similarly, we found no associations between family history of stroke and stillbirth (OR 1.00, 95% CI 0.82, 1.21), neonatal death (OR 1.09, 95%CI 0.84, 1.41) or perinatal death (OR 1.02, 95% CI 0.88, 1.20).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Limitations<\/jats:title>\n<jats:p>Socioeconomic background of fathers was captured using imperfect proxy. Potential misclassification of family history and selection bias should be considered.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Results of this large, cohort study including half-a million births, do not indicate an association between paternal family history of premature atherosclerotic disease and perinatal death.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313821","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T19:26:49Z","timestamp":1736364409000},"page":"e0313821","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-3826","authenticated-orcid":true,"given":"Shwe Sin","family":"Win","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Klungs\u00f8yr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace M.","family":"Egeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Sulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"pone.0313821.ref001","unstructured":"World Health Organization. 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Blanco-Mu\u00f1oz","year":"2009","journal-title":"Public Health Reports (1974-)"},{"key":"pone.0313821.ref018","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1365-2125.2012.04426.x","article-title":"Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340 000 pregnancies using Norwegian population-based databases","volume":"75","author":"A Engeland","year":"2013","journal-title":"British Journal of Clinical Pharmacology"},{"key":"pone.0313821.ref019","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(99)04138-0","article-title":"Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant","volume":"354","author":"L Parker","year":"1999","journal-title":"The Lancet"},{"key":"pone.0313821.ref020","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM200103223441201","article-title":"Paternal and Maternal Components of the Predisposition to 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father","volume":"89","author":"G Dekker","year":"2011","journal-title":"Journal of Reproductive Immunology"},{"key":"pone.0313821.ref024","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ajog.2005.08.019","article-title":"Familial aggregation of small-for-gestational-age births: The importance of fetal genetic effects","volume":"194","author":"AC Svensson","year":"2006","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"pone.0313821.ref025","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/bmj.316.7141.1343","article-title":"Fetal and maternal contributions to risk of pre-eclampsia: population based study","volume":"316","author":"RT Lie","year":"1998","journal-title":"BMJ"},{"key":"pone.0313821.ref026","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3389\/fphys.2018.01870","article-title":"Paternal Determinants in Preeclampsia.","volume":"9","author":"C Galaviz-Hernandez","year":"2019","journal-title":"Front Physiol"},{"key":"pone.0313821.ref027","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00125-019-4919-9","article-title":"Paternal impact on the life course development of obesity and type 2 diabetes in the offspring","volume":"62","author":"GC Sharp","year":"2019","journal-title":"Diabetologia"},{"key":"pone.0313821.ref028","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/humrep\/deaa332","article-title":"Association between preconception paternal health and pregnancy loss in the USA: an analysis of US claims data","volume":"36","author":"AM Kasman","year":"2020","journal-title":"Human Reproduction (Oxford, England)"},{"key":"pone.0313821.ref029","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed.,","author":"ME Silverman","year":"1990"},{"key":"pone.0313821.ref030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12016-012-8316-0","article-title":"Recurrent Miscarriage, Antiphospholipid Antibodies and the Risk of Thromboembolic Disease.","volume":"43","author":"M\u00c1 Mart\u00ednez-Zamora","year":"2012","journal-title":"Clinical Reviews in Allergy & Immunology"},{"key":"pone.0313821.ref031","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1471-0528.2010.02890.x","article-title":"Recurrent miscarriage is associated with a family history of ischaemic heart disease: a retrospective cohort study.","volume":"118","author":"G Smith","year":"2011","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"key":"pone.0313821.ref032","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/eurheartj\/ehv549","article-title":"Association between pregnancy losses in women and risk of atherosclerotic disease in their relatives: a nationwide cohort study\u2020","volume":"37","author":"MF Ranthe","year":"2016","journal-title":"European Heart Journal"},{"key":"pone.0313821.ref033","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.semperi.2003.10.012","article-title":"First trimester origins of fetal growth impairment.","volume":"28","author":"GCS Smith","year":"2004","journal-title":"Seminars in Perinatology"},{"key":"pone.0313821.ref034","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/bmj.39366.416817.BE","article-title":"Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study","volume":"335","author":"EB Magnussen","year":"2007","journal-title":"BMJ"},{"key":"pone.0313821.ref035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.semperi.2007.07.009","article-title":"Population-Based Investigations to Study the Association of Cardiovascular Polymorphisms and Adverse Pregnancy Outcome","volume":"31","author":"JA Lykke","year":"2007","journal-title":"Seminars in Perinatology"},{"key":"pone.0313821.ref036","doi-asserted-by":"crossref","first-page":"e017034","DOI":"10.1136\/bmjopen-2017-017034","article-title":"Association between pregravid physical activity and family history of stroke and risk of stillbirth: population-based cohort study","volume":"7","author":"GM Egeland","year":"2017","journal-title":"BMJ Open"},{"key":"pone.0313821.ref037","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.annepidem.2019.04.002","article-title":"Cardiovascular disease family history and risk of pregnancy loss.","volume":"34","author":"EH Yeung","year":"2019","journal-title":"Annals of Epidemiology"},{"key":"pone.0313821.ref038","article-title":"40-\u00e5ringsunders\u00f8kelsene\u2013 400 000 menn og kvinner har m\u00f8tt opp","author":"A Tverdal","year":"2002","journal-title":"Tidsskrift for Den norske legeforening"},{"key":"pone.0313821.ref039","first-page":"1","article-title":"The cardiovascular disease study in Norwegian counties. Background and organization","volume":"634","author":"K Bjartveit","year":"1979","journal-title":"Acta Medica Scandinavica Supplementum"},{"key":"pone.0313821.ref040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/ije\/dym217","article-title":"Cohort Profile: Cohort of Norway (CONOR).","volume":"37","author":"O Naess","year":"2008","journal-title":"International Journal of Epidemiology"},{"key":"pone.0313821.ref041","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1034\/j.1600-0412.2000.079006435.x","article-title":"The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years.","volume":"79","author":"LM Irgens","year":"2000","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"pone.0313821.ref042","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1034\/j.1600-0412.2000.079006440.x","article-title":"Birthweight by gestational age in Norway: Birthweight by gestational age in Norway.","volume":"79","author":"R Skjaerven","year":"2000","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"pone.0313821.ref043","first-page":"1887","article-title":"Robust causal inference using directed acyclic graphs: the R package \u2018dagitty","volume":"45","author":"J Textor","year":"2016","journal-title":"International Journal of Epidemiology"},{"key":"pone.0313821.ref044","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12916-023-03223-9","article-title":"Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study","volume":"22","author":"\u00c1 Hern\u00e1ez","year":"2024","journal-title":"BMC Medicine"},{"key":"pone.0313821.ref045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-3016.2007.00832.x","article-title":"Intergenerational exchange and perinatal risks: a note on interpretation of generational recurrence risks","volume":"21","author":"RT Lie","year":"2007","journal-title":"Paediatric and Perinatal Epidemiology"},{"key":"pone.0313821.ref046","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/biology13030165","article-title":"The \u201cBad Father\u201d: Paternal Role in Biology of Pregnancy and in Birth Outcome","volume":"13","author":"SR Giannubilo","year":"2024","journal-title":"Biology"},{"key":"pone.0313821.ref047","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/oby.2010.279","article-title":"Paternal Contribution to Small for Gestational Age Babies: A Multicenter Prospective Study.","volume":"19","author":"LM McCowan","year":"2011","journal-title":"Obesity"},{"key":"pone.0313821.ref048","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2337\/dc12-1280","article-title":"Paternal Metabolic and Cardiovascular Risk Factors for Fetal Growth Restriction: A case-control study","volume":"36","author":"S Hillman","year":"2013","journal-title":"Diabetes Care"},{"key":"pone.0313821.ref049","doi-asserted-by":"crossref","first-page":"826665","DOI":"10.3389\/fendo.2022.826665","article-title":"Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study.","volume":"13","author":"J Lin","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"pone.0313821.ref050","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1017\/S000711452200054X","article-title":"Preconception paternal\/maternal BMI and risk of small\/large for gestational age infant in over 4\u00b77 million Chinese women aged 20\u201349 years: a population-based cohort study in China","volume":"129","author":"T Guo","year":"2023","journal-title":"British Journal of Nutrition"},{"key":"pone.0313821.ref051","unstructured":"Medisinsk f\u00f8dselsregister\u2014statistikkbank n.d. https:\/\/statistikkbank.fhi.no\/mfr\/ (accessed August 26, 2024)."},{"key":"pone.0313821.ref052","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-3016.2009.01062.x","article-title":"Self-selection and bias in a large prospective pregnancy cohort in Norway.","volume":"23","author":"RM Nilsen","year":"2009","journal-title":"Paediatric and Perinatal Epidemiology"},{"key":"pone.0313821.ref053","first-page":"124","volume-title":"Dealing with Biases. 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