{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:01:36Z","timestamp":1754110896784,"version":"3.30.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPESP (FUNDA\u00c7\u00c3O DE APOIO \u00c0 PESQUISA DO ESTADO DE S\u00c3O PAULO"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The study aimed to evaluate bone repair using three osteoinductive polymers in bone defects created in rabbit tibias. Forty-eight adult rabbits were assessed at various time points: three, seven, fourteen, and thirty days. The groups included a control group (without biomaterial), M1 (Poly L Lactide co Polycaprolactone\/Polyethylene Glycol), M2 (Poly L Lactide co Polycaprolactone\/Polyethylene Glycol\/\u03b2-Tricalcium Phosphate), and M3 (Poly L Lactide co Polycaprolactone\/Polyethylene Glycol\/nano hydroxyapatite). Histomorphometric analysis was conducted to evaluate new bone formation within and around the bone defect. At 14 (p&lt;0.05) and 30 days (p&lt;0.05), the callus area in the membrane groups, particularly in M3, was also significantly larger than in the control group, indicating the osteoinductive potential of these biomaterials. The callus consisted of both bone and cartilaginous matrix, suggesting a robust activation of endochondral ossification. The number of osteoclast was higher in the membrane groups, especially at 14 days in the M3 group, indicating increased bone remodeling activity. The membranes were not fully absorbed by 30 days, creating a space between the defect and the periosteum. In conclusion, all three membranes showed significant chondro and osteoinductive potential, with the membrane containing nano-hydroxyapatite demonstrating the most pronounced potential.<\/jats:p>","DOI":"10.1371\/journal.pone.0313834","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T19:00:50Z","timestamp":1733425250000},"page":"e0313834","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biological interaction of bioactive polymeric membranes in induced bone defects in rabbit tibias"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-1290","authenticated-orcid":true,"given":"Olicies","family":"da Cunha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-989X","authenticated-orcid":true,"given":"C\u00e1ssio Ricardo Auada","family":"Ferrigno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solimar Dutra","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Gregnanin","family":"Pedron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Tiemi","family":"Komorizono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Cristina Rosin","family":"Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Israel Rojas","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-0750","authenticated-orcid":true,"given":"Luciana","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"pone.0313834.ref001","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/B978-1-4377-0792-2.50031-6","volume-title":"Pathologic basis of disease. 8th ed.","author":"AE Rosenberg","year":"2010"},{"key":"pone.0313834.ref002","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/BOT.0b013e3181ed1361","article-title":"Trauma-Induced Inflammation and Fracture Healing.","volume":"24","author":"HC Pape","year":"2010","journal-title":"Journal Orthopedic Trauma"},{"key":"pone.0313834.ref003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1615\/CritRevEukarGeneExpr.v17.i3.30","article-title":"Role of Bone Regeneration and Turnover Modulators in Control of Fracture","volume":"17","author":"N Rozen","year":"2007","journal-title":"Critical Reviews\u2122 in Eukaryotic Gene Expression"},{"key":"pone.0313834.ref004","first-page":"459","article-title":"Bone remodeling during fracture repair: The cellular picture. 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