{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:49:56Z","timestamp":1791848996519,"version":"4.3.4"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Fourth People's Hospital of Chengdu","award":["XJLL2023007"],"award-info":[{"award-number":["XJLL2023007"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nWith the increasing utilization of cardiac rehabilitation in clinical treatment and prognosis for patients with cardiovascular diseases, exercise training has become a crucial component. High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) are commonly employed in rehabilitating patients with cardiovascular diseases. However, further investigation is required to determine whether HIIT and MICT can effectively enhance the prognosis of patients with coronary artery disease. Therefore, this study aims to assess the effectiveness of HIIT and MICT interventions, optimal intervention duration for different intensity levels of training, as well as effective training modalities that improve cardiorespiratory function and exercise capacity among patients.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nWe conducted a comprehensive search of the Cochrane Library, PubMed, EMbase, Web of Science, and CINAHL databases for randomized controlled trials (RCTs) pertaining to high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) interventions in patients with coronary artery disease from inception until publication on September 26, 2024. Two independent researchers assessed articles that met the inclusion criteria and analyzed the results using Sata 17.0 software. Forest plots were employed to evaluate the impact of HIIT and MICT on outcome indicators. Sensitivity analysis and funnel plot assessment were performed to examine publication bias. Subgroup analysis was conducted to determine optimal intervention duration and training methods.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nA total of 22 studies with 1364 patients were included in the study, including the HIIT group (n = 685) and the MICT group (n = 679). The results showed that compared to MICT, HIIT significantly increased PeakVO2<\/jats:sub>(Peak oxygen uptake)[WMD = 1.42mL \/kg\/min 95%CI (0.87, 1.98), P = 0.870, I2<\/jats:sup> = 0%], 6MWT(6-minute walk test)[WMD = 18.60m 95%CI (2.29, 34.92), P = 0.789, I2<\/jats:sup> = 0%], PHR(Peak heart rate)[WMD = 4.21bpm 95%CI (1.07, 7.36), P = 0.865, I2<\/jats:sup> = 0%], DBP(diastolic blood pressure)[WMD = 3.43mmHg 95%CI (1.09, 5.76), P = 0.004, I2<\/jats:sup> = 60.2%]. However, in LVEF(left- ventricular ejection fraction)[WMD = 0.32mL 95%CI (-1.83, 2.46), P = 0.699, I2<\/jats:sup> = 0%], LVEDV(left ventricular end-diastolic volume)[WMD = 0.91 ml 95%CI (-1.83, 2.46), P = 0.995, I2<\/jats:sup> = 0%] and SBP(systolic blood pressure)[WMD = 1.85mmHg 95%CI (-0.23, 3.93),P = 0.266, I2<\/jats:sup> = 18.2%], there was no significant difference between HIIT and MICT.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nBased on the findings of this systematic review, HIIT demonstrates superior efficacy compared to MICT in enhancing PeakVO2<\/jats:sub>, PHR, 6MWT and DBP. However, no significant differences were observed in LVEF, LVEDV, and SBP. In summary, HIIT exhibits potential for improving cardiopulmonary function and exercise capacity among patients with coronary artery disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0314134","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T18:28:12Z","timestamp":1740076092000},"page":"e0314134","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7878-6142","authenticated-orcid":true,"given":"Chao","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6935-049X","authenticated-orcid":true,"given":"Yuchuan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"issue":"8","key":"pone.0314134.ref001","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"149","author":"SS Martin","year":"2024","journal-title":"Circulation"},{"issue":"25","key":"pone.0314134.ref002","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"GA Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"pone.0314134.ref003","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jacc.2024.04.051","article-title":"Percutaneous Coronary Revascularization Strategies After Myocardial Infarction: A Systematic Review and Network Meta-Analysis","volume":"84","author":"RK Reddy","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"pone.0314134.ref004","doi-asserted-by":"crossref","first-page":"100408","DOI":"10.1016\/j.clinsp.2024.100408","article-title":"Effects of different early cardiac rehabilitation exercise treatments on the prognosis of acute myocardial infarction patients receiving percutaneous coronary intervention","volume":"79","author":"H Liang","year":"2024","journal-title":"Clinics (Sao Paulo)"},{"key":"pone.0314134.ref005","doi-asserted-by":"crossref","first-page":"961414","DOI":"10.3389\/fcvm.2022.961414","article-title":"Effects of high-intensity and moderate-intensity exercise training on cardiopulmonary function in patients with coronary artery disease: A meta-analysis","volume":"9","author":"L Zheng","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"pone.0314134.ref006","article-title":"Safety and long-term outcomes of remote cardiac rehabilitation in coronary heart disease patients: A systematic review","volume":"10","author":"V Antoniou","year":"2024","journal-title":"Digit Health"},{"issue":"5","key":"pone.0314134.ref007","article-title":"Exercise Training and Interventions for Coronary Artery Disease","volume":"9","author":"H Fern\u00e1ndez-Rubio","year":"2022","journal-title":"J Cardiovasc Dev Dis"},{"issue":"16","key":"pone.0314134.ref008","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/2047487320905719","article-title":"Effectiveness of comprehensive cardiac rehabilitation in coronary artery disease patients treated according to contemporary evidence based medicine: Update of the Cardiac Rehabilitation Outcome Study (CROS-II)","volume":"27","author":"A Salzwedel","year":"2020","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"pone.0314134.ref009","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/ehaa605","article-title":"2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease","volume":"42","author":"A Pelliccia","year":"2021","journal-title":"Eur Heart J"},{"issue":"2","key":"pone.0314134.ref010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jphys.2023.02.011","article-title":"Appraisal of Clinical Practice Guideline: Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how. 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