{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:07:04Z","timestamp":1787778424618,"version":"build-2784847793"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the overall efficacy of early enteral nutrition support on the nutritional status of patients following gallstone surgery, providing a theoretical basis for its application in postoperative care.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective analysis was conducted on 98 hospitalized patients who underwent gallstone surgery between February 2021 and March 2023. The patients were divided into two groups: the study group, which received early nutritional intervention, and the control group, which started nutritional support three days post-surgery. The primary objective was to assess nutritional status, while secondary objectives included gastrointestinal function, immune function markers, and the incidence of postoperative and gastrointestinal complications. Nutritional status, gastrointestinal function, immune function, and complications were compared between the two groups before and one week after intervention.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>After the intervention, the study group showed significantly higher levels of total protein (TP), prealbumin (PAB), albumin (ALB), transferrin (TF), and body mass index (BMI) compared to the control group (P&lt;0.05). Additionally, the scores for Nutrition Risk Screening 2002 (NRS 2002) and the Malnutrition Universal Screening Tool (MUST) were notably lower in the study group (P&lt;0.05). Postoperatively, the study group experienced shorter times to first exhaust, defecation, bowel sound recovery, first meal, and overall hospital stay compared to the control group (P&lt;0.05). Although the pre-intervention levels of CD3+, CD4+, CD8+, and CD4+\/CD8+ were comparable between the groups (P&gt;0.05), these immune markers were significantly higher in the study group post-intervention (P&lt;0.05). The incidence of both postoperative and gastrointestinal complications was significantly lower in the study group than in the control group (both P&lt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Early enteral nutrition support significantly improves the nutritional status of patients after gallstone surgery, enhances gastrointestinal and immune function, and reduces the occurrence of complications. These findings underscore its clinical significance and value in postoperative care.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0314659","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:34:32Z","timestamp":1739385272000},"page":"e0314659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of early enteral nutrition support on the nutritional status of patients after gallstone surgery"],"prefix":"10.1371","volume":"20","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6452-8313","authenticated-orcid":true,"given":"Yun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"issue":"4","key":"pone.0314659.ref001","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/gastro\/goz022","article-title":"How to choose the most appropriate technique for the single-stage treatment of cholecysto-choledocolithiasis[J]","volume":"7","author":"A Bove","year":"2019","journal-title":"Gastroenterol Rep (Oxf)."},{"issue":"11","key":"pone.0314659.ref002","first-page":"1115","article-title":"Gallstone ileus with cholecysto-ileal fistula: One stage surgery in an extremely-elderly patient[J].","volume":"43","author":"S Fujisaki","year":"2020","journal-title":"Asian J Surg"},{"issue":"3","key":"pone.0314659.ref003","first-page":"301","article-title":"Postoperative Changes in Nutritional and Functional Status of Gastroesophageal Cancer Patients[J].","volume":"41","author":"I Lidoriki","year":"2022","journal-title":"J Am Nutr Assoc."},{"issue":"3","key":"pone.0314659.ref004","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ncp.10404","article-title":"Effect of Oral Versus Intramuscular Vitamin D Replacement on Oxidative Stress and Outcomes in Traumatic Mechanical Ventilated Patients Admitted to Intensive Care Unit.","volume":"35","author":"MAV Hasanloei","year":"2020","journal-title":"Nutr Clin Pract."},{"issue":"1","key":"pone.0314659.ref005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/1747-0080.12721","article-title":"Efficacy of early enteral nutrition versus total parenteral nutrition for patients with gastric cancer complicated with diabetes mellitus: A systematic review and meta-analysis[J]","volume":"79","author":"K Li","year":"2022","journal-title":"Nutr Diet"},{"issue":"2","key":"pone.0314659.ref006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/JNN.0000000000000121","article-title":"Weight reduction after severe brain injury:a challenge during the rehabilitation course[J]","volume":"47","author":"L Aadal","year":"2015","journal-title":"J Neurosci Nurs"},{"issue":"23","key":"pone.0314659.ref007","first-page":"2513","article-title":"Effect of enteral and parenteral nutrition support in the treatment of early severe stroke patients [J].","volume":"19","author":"C Fan","journal-title":"Journal of Clinical and Experimental Medicine"},{"issue":"21","key":"pone.0314659.ref008","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.3390\/nu15214665","article-title":"Parenteral Nutrition: Current Use, Complications, and Nutrition Delivery in Critically Ill Patients[J].","volume":"15","author":"JC Lopez-Delgado","year":"2023","journal-title":"Nutrients"},{"issue":"11","key":"pone.0314659.ref009","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3390\/nu14112180","article-title":"Enteral Nutrition Overview[J].","volume":"14","author":"J. 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Niu","journal-title":"Journal of Hebei North University (Natural Science Edition),"},{"issue":"10","key":"pone.0314659.ref022","first-page":"1629","article-title":"Clinical study of NRS2002 score in predicting the prognosis of adult ICU patients [J]","volume":"16","author":"X Liu","year":"2018","journal-title":"Chinese Journal of General Medicine"},{"issue":"002","key":"pone.0314659.ref023","first-page":"140","article-title":"Comparison of preoperative nutritional risk assessment in patients with gastric cancer by different nutritional scoring systems [J].","volume":"009","author":"W Guo","year":"2010","journal-title":"Chinese Journal of Digestive Surgery"},{"issue":"17","key":"pone.0314659.ref024","first-page":"2628","article-title":"Effects of FTS-CIS nursing combined with early enteral nutrition on nutritional status and enteral nutrition-related complications in patients with esophageal cancer after surgery [J]","volume":"18","author":"J. 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