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However, statins cross the blood-brain barrier and decrease neural cholesterol in animal models, raising concern that long-term statin use may impact cholesterol-dependent structures and functions in the brain. Cholesterol is a fundamental component of cell membranes and experimentally decreasing membrane cholesterol has been shown to alter cell morphology <jats:italic>in vitro.<\/jats:italic> In addition, brain regions that undergo adult neurogenesis rely on local brain cholesterol for the manufacture of new neuronal membranes. Thus neurogenesis may be particularly vulnerable to long-term statin use. Here we asked whether oral statin treatment impacts neurogenesis in juveniles, either by decreasing numbers of new cells formed or altering the structure of new neurons. The use of statins in children and adolescents has received less attention than in older adults, with few studies on potential unintended effects in young brains. We examined neurons in the juvenile zebra finch songbird in telencephalic regions that function in song perception and memory (caudomedial nidopallium, NCM) and song production (HVC). Birds received either 40\u2009mg\/kg of atorvastatin in water or water vehicle once daily for 2\u20133 months until they reached adulthood. We labeled newborn cells using systemic injections of bromodeoxyuridine (BrdU) and quantified cells double-labeled with antibodies for BrdU and the neuron-specific protein Hu 30\u201332 days post mitosis. We also quantified a younger cohort of new neurons in the same birds using antibody to the neuronal protein doublecortin (DCX). We then compared numbers of new neurons and soma morphology of BrdU\u2009+\u2009\/Hu+ neurons between statin-treated and control birds. We did not find an effect of statins on the density of newly formed neurons in either brain region, suggesting that statin treatment did not impact neurogenesis or young neuron survival in our paradigm. However, we found that neuronal soma morphology differed significantly between statin-treated and control birds. Somata of BrdU\u2009+\u2009\/Hu+ (30\u201332 day old) neurons were flatter and had more furrowed contours in statin-treated birds relative to controls. In a larger, heterogeneous cohort of non-birthdated BrdU-\/Hu+ neurons, largely born prior to statin treatment, somata were smaller in statin-treated birds than in controls. Our findings indicate that atorvastatin may affect neural cytoarchitecture in both newly formed and mature neurons, perhaps as a consequence of decreased cholesterol availability in the brain.<\/jats:p>","DOI":"10.1371\/journal.pone.0314690","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T17:22:56Z","timestamp":1745860976000},"page":"e0314690","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model"],"prefix":"10.1371","volume":"20","author":[{"given":"Shuk C.","family":"Tsoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia C.","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Vicario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi L.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-0532","authenticated-orcid":true,"given":"Carolyn L.","family":"Pytte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"pone.0314690.ref001","article-title":"Hypercholesterolemia","volume-title":"StatPearls","author":"MA Ibrahim","year":"2020"},{"key":"pone.0314690.ref002","article-title":"Cholesterol Lowering Drugs.","volume-title":"Endotext","author":"KR. Feingold","year":"2000"},{"issue":"2","key":"pone.0314690.ref003","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1124\/jpet.104.075028","article-title":"Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex","volume":"312","author":"LN Johnson-Anuna","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"pone.0314690.ref004","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0022-3565(25)39496-6","article-title":"Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier","volume":"267","author":"A Tsuji","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"pone.0314690.ref005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/archneur.59.2.213","article-title":"Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that 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Reis","year":"2012","journal-title":"PLoS Pathog"},{"issue":"8","key":"pone.0314690.ref024","first-page":"1113","article-title":"Statins excert neuroprotection on cerebral ischemia independent of their lipid-lowering action: the potential molecular mechanisms","volume":"18","author":"Q Li","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"pone.0314690.ref025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-018-0110-3","article-title":"The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms","volume":"7","author":"BG Schultz","year":"2018","journal-title":"Transl Neurodegener"},{"key":"pone.0314690.ref026","unstructured":"U.S. Food and Drug AdministrationFDA Consumer Health Information: FDA Expands Advice on Statin Risks. 2012. Available from: www.fda.gov\/consumer"},{"issue":"21","key":"pone.0314690.ref027","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.jacc.2019.09.041","article-title":"Effects of Statins on Memory, Cognition, and Brain Volume in the Elderly","volume":"74","author":"K Samaras","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"pone.0314690.ref028","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1592\/phco.23.7.871.32720","article-title":"Statin-associated memory loss: analysis of 60 case reports and review of the literature","volume":"23","author":"LR Wagstaff","year":"2003","journal-title":"Pharmacotherapy"},{"issue":"1","key":"pone.0314690.ref029","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jacl.2020.10.007","article-title":"Association between statin use and cognitive function: A systematic review of randomized clinical trials and observational studies","volume":"15","author":"A Adhikari","year":"2021","journal-title":"J Clin Lipidol"},{"key":"pone.0314690.ref030","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.2337\/dcS15-3022","article-title":"Remembering Statins: Do Statins Have Adverse Cognitive Effects?","volume":"39 Suppl 2","author":"R Bitzur","year":"2016","journal-title":"Diabetes Care"},{"issue":"2","key":"pone.0314690.ref031","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s40268-024-00474-6","article-title":"Exploring the Relationship Between Atorvastatin and Memory Loss: A Comprehensive Analysis Integrating Real-World Pharmacovigilance and Mendelian Randomization","volume":"24","author":"K Chen","year":"2024","journal-title":"Drugs R D"},{"issue":"3","key":"pone.0314690.ref032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/17512433.2024.2311875","article-title":"Statin-related neurocognitive disorder: a real-world pharmacovigilance study based on the FDA adverse event reporting system","volume":"17","author":"M Xiao","year":"2024","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"1","key":"pone.0314690.ref033","article-title":"Statins-Beyond Their Use in Hypercholesterolemia: Focus on the Pediatric Population","volume":"11","author":"EL Spoiala","year":"2024","journal-title":"Children (Basel)"},{"issue":"2","key":"pone.0314690.ref034","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2012.10.032","article-title":"Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?","volume":"226","author":"A Vuorio","year":"2013","journal-title":"Atherosclerosis"},{"issue":"8","key":"pone.0314690.ref035","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/ATVBAHA.107.145151","article-title":"A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia","volume":"27","author":"HJ Avis","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"pone.0314690.ref036","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11892-014-0499-8","article-title":"Risks and benefits of statin use in young people with type 1 diabetes","volume":"14","author":"P Bjornstad","year":"2014","journal-title":"Curr Diab Rep"},{"issue":"4","key":"pone.0314690.ref037","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2165\/11591650-000000000-00000","article-title":"Long-term follow-up of statin treatment in a cohort of children with familial hypercholesterolemia: efficacy and tolerability","volume":"13","author":"V Carreau","year":"2011","journal-title":"Paediatr Drugs"},{"issue":"1","key":"pone.0314690.ref038","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1515\/JPEM.2009.22.1.65","article-title":"Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus","volume":"22","author":"MJ Haller","year":"2009","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"5","key":"pone.0314690.ref039","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1203\/00006450-199605000-00021","article-title":"Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia","volume":"39","author":"HC Knipscheer","year":"1996","journal-title":"Pediatr Res"},{"key":"pone.0314690.ref040","first-page":"1","article-title":"Considering statins for cholesterol-reduction in children if lifestyle and diet changes do not improve their health: a review of the risks and benefits","volume":"7","author":"CS O\u2019Gorman","year":"2011","journal-title":"Vasc Health Risk Manag"},{"issue":"3","key":"pone.0314690.ref041","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/jama.292.3.331","article-title":"Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial","volume":"292","author":"A Wiegman","year":"2004","journal-title":"JAMA"},{"issue":"10","key":"pone.0314690.ref042","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrn2233","article-title":"A neuroscientist\u2019s guide to lipidomics","volume":"8","author":"D Piomelli","year":"2007","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"pone.0314690.ref043","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1515\/BC.2009.035","article-title":"Central nervous system: cholesterol turnover, brain development and neurodegeneration","volume":"390","author":"JM Dietschy","year":"2009","journal-title":"Biol Chem"},{"issue":"8","key":"pone.0314690.ref044","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal","volume":"45","author":"JM Dietschy","year":"2004","journal-title":"J Lipid Res"},{"issue":"12","key":"pone.0314690.ref045","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1128\/IAI.73.12.7791-7796.2005","article-title":"Membrane cholesterol: a crucial molecule affecting interactions of microbial pathogens with mammalian cells","volume":"73","author":"P Goluszko","year":"2005","journal-title":"Infect Immun"},{"issue":"1","key":"pone.0314690.ref046","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbamem.2010.10.013","article-title":"Transbilayer organization of membrane cholesterol at low concentrations: Implications in health and disease","volume":"1808","author":"A Chaudhuri","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"26","key":"pone.0314690.ref047","doi-asserted-by":"crossref","first-page":"15443","DOI":"10.1074\/jbc.270.26.15443","article-title":"Intracellular cholesterol transport and compartmentation","volume":"270","author":"L Liscum","year":"1995","journal-title":"J Biol Chem"},{"issue":"5497","key":"pone.0314690.ref048","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How cells handle cholesterol","volume":"290","author":"K Simons","year":"2000","journal-title":"Science"},{"issue":"11","key":"pone.0314690.ref049","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11745-004-1336-x","article-title":"What\u2019s so special about cholesterol?","volume":"39","author":"OG Mouritsen","year":"2004","journal-title":"Lipids"},{"issue":"1","key":"pone.0314690.ref050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0892-0362(95)91641-W","article-title":"An in vitro study of the effects of lovastatin on human fetal brain cells","volume":"17","author":"OV Pavlov","year":"1995","journal-title":"Neurotoxicol Teratol"},{"issue":"8","key":"pone.0314690.ref051","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1523\/JNEUROSCI.20-08-02852.2000","article-title":"Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition","volume":"20","author":"T Tanaka","year":"2000","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0314690.ref052","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0047-6374(98)00134-1","article-title":"Apolipoprotein E4 isoform-specific actions on neuronal cells in culture","volume":"107","author":"M Michikawa","year":"1999","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"pone.0314690.ref053","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1471-4159.2003.02305.x","article-title":"HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis","volume":"89","author":"JG Schulz","year":"2004","journal-title":"J Neurochem"},{"issue":"7","key":"pone.0314690.ref054","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1096\/fasebj.3.7.2469614","article-title":"Lipid regulation of cell membrane structure and function","volume":"3","author":"PL Yeagle","year":"1989","journal-title":"FASEB J"},{"issue":"5","key":"pone.0314690.ref055","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1471-4159.2011.07474.x","article-title":"Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol","volume":"119","author":"T Mailman","year":"2011","journal-title":"J Neurochem"},{"issue":"1","key":"pone.0314690.ref056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.20422","article-title":"Statins induce differentiation and cell death in neurons and astroglia","volume":"55","author":"P M\u00e4rz","year":"2007","journal-title":"Glia"},{"issue":"1","key":"pone.0314690.ref057","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.expneurol.2008.09.010","article-title":"Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination","volume":"215","author":"Z Xiang","year":"2009","journal-title":"Exp Neurol"},{"issue":"20","key":"pone.0314690.ref058","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1073\/pnas.0903541106","article-title":"Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis","volume":"106","author":"K Saito","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0314690.ref059","doi-asserted-by":"crossref","first-page":"37","DOI":"10.12703\/P7-37","article-title":"Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration","volume":"7","author":"S Theofilopoulos","year":"2015","journal-title":"F1000Prime Rep"},{"key":"pone.0314690.ref060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nbd.2016.02.017","article-title":"Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain","volume":"91","author":"AM Driver","year":"2016","journal-title":"Neurobiol Dis"},{"issue":"5","key":"pone.0314690.ref061","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/cne.25245","article-title":"DARPP-32 distinguishes a subset of adult-born neurons in zebra finch HVC","volume":"530","author":"JV Aronowitz","year":"2022","journal-title":"J Comp 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Neurol"},{"issue":"36","key":"pone.0314690.ref066","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1523\/JNEUROSCI.4869-05.2006","article-title":"High levels of new neuron addition persist when the sensitive period for song learning is experimentally prolonged","volume":"26","author":"L Wilbrecht","year":"2006","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0314690.ref067","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1006\/anbe.1999.1416","article-title":"A procedure for an automated measurement of song similarity","volume":"59","author":"O Tchernichovski","year":"2000","journal-title":"Anim Behav"},{"issue":"2","key":"pone.0314690.ref068","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"AB Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"issue":"9","key":"pone.0314690.ref069","doi-asserted-by":"crossref","first-page":"e108675","DOI":"10.1371\/journal.pone.0108675","article-title":"Is the rate of metabolic ageing and survival determined by Basal metabolic rate in the zebra finch?","volume":"9","author":"B R\u00f8nning","year":"2014","journal-title":"PLoS One"},{"key":"pone.0314690.ref070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphys.2013.00034","article-title":"Measuring energy metabolism in the mouse - theoretical, practical, and analytical considerations","volume":"4","author":"JR Speakman","year":"2013","journal-title":"Front Physiol"},{"issue":"1","key":"pone.0314690.ref071","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0166-4328(01)00416-8","article-title":"Social change affects the survival of new neurons in the forebrain of adult songbirds","volume":"133","author":"D Lipkind","year":"2002","journal-title":"Behav Brain Res"},{"issue":"2","key":"pone.0314690.ref072","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/neu.480250206","article-title":"Hu neuronal proteins are expressed in proliferating neurogenic cells","volume":"25","author":"MF Marusich","year":"1994","journal-title":"J Neurobiol"},{"issue":"1","key":"pone.0314690.ref073","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/neu.480280108","article-title":"Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain","volume":"28","author":"K Barami","year":"1995","journal-title":"J Neurobiol"},{"issue":"4","key":"pone.0314690.ref074","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1460-9568.2008.06059.x","article-title":"Doublecortin as a marker of adult neuroplasticity in the canary song control nucleus HVC","volume":"27","author":"J Balthazart","year":"2008","journal-title":"Eur J Neurosci"},{"issue":"11 Pt 1","key":"pone.0314690.ref075","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1523\/JNEUROSCI.14-11-06652.1994","article-title":"Song-induced ZENK gene expression in auditory pathways of songbird brain and its relation to the song control system","volume":"14","author":"CV Mello","year":"1994","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0314690.ref076","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/cne.903250306","article-title":"Cytoarchitectonic organization and morphology of cells of the field L complex in male zebra finches (Taenopygia guttata)","volume":"325","author":"ES Fortune","year":"1992","journal-title":"J Comp Neurol"},{"issue":"2","key":"pone.0314690.ref077","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbr.2010.03.029","article-title":"Deafening decreases neuronal incorporation in the zebra finch caudomedial nidopallium (NCM)","volume":"211","author":"CL Pytte","year":"2010","journal-title":"Behav Brain Res"},{"issue":"6","key":"pone.0314690.ref078","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1460-9568.2007.05418.x","article-title":"HVC interneurons are not renewed in adult male zebra finches","volume":"25","author":"S Scotto-Lomassese","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"4","key":"pone.0314690.ref079","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s00429-015-1006-y","article-title":"Young, active and well-connected: adult-born neurons in the zebra finch are activated during singing","volume":"221","author":"K Tokarev","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"8","key":"pone.0314690.ref080","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1523\/JNEUROSCI.08-08-02869.1988","article-title":"Sex and regional differences in the incorporation of neurons born during song learning in zebra finches","volume":"8","author":"EJ Nordeen","year":"1988","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0314690.ref081","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1523\/JNEUROSCI.11-06-01756.1991","article-title":"Production and survival of projection neurons in a forebrain vocal center of adult male canaries","volume":"11","author":"JR Kirn","year":"1991","journal-title":"J Neurosci"},{"issue":"1","key":"pone.0314690.ref082","doi-asserted-by":"crossref","first-page":"46","DOI":"10.15283\/ijsc.2010.3.1.46","article-title":"Timing of the cell cycle exit of differentiating hippocampal neural stem cells","volume":"3","author":"E J\u00e4rvinen","year":"2010","journal-title":"Int J Stem Cells"},{"key":"pone.0314690.ref083","doi-asserted-by":"crossref","first-page":"126078","DOI":"10.1155\/2015\/126078","article-title":"The cell birth marker BrdU does not affect recruitment of subsequent cell divisions in the adult avian brain","volume":"2015","author":"A Cattan","year":"2015","journal-title":"Biomed Res Int"},{"issue":"4","key":"pone.0314690.ref084","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain","volume":"6","author":"J Zhang","year":"2015","journal-title":"Protein Cell"},{"issue":"9","key":"pone.0314690.ref085","doi-asserted-by":"crossref","first-page":"e108929","DOI":"10.1371\/journal.pone.0108929","article-title":"Hemispheric asymmetry in new neurons in adulthood is associated with vocal learning and auditory memory","volume":"9","author":"SC Tsoi","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"pone.0314690.ref086","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/cne.21296","article-title":"Developmental origin and identity of song system neurons born during vocal learning in songbirds","volume":"502","author":"BB Scott","year":"2007","journal-title":"J Comp Neurol"},{"issue":"22","key":"pone.0314690.ref087","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1073\/pnas.85.22.8722","article-title":"Birth of projection neurons in the higher vocal center of the canary forebrain before, during, and after song learning","volume":"85","author":"A Alvarez-Buylla","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0314690.ref088","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/(SICI)1096-9861(19990830)411:3<487::AID-CNE10>3.0.CO;2-M","article-title":"Fate of new neurons in adult canary high vocal center during the first 30 days after their formation","volume":"411","author":"JR Kirn","year":"1999","journal-title":"J Comp Neurol"},{"issue":"2","key":"pone.0314690.ref089","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0896-6273(00)80910-1","article-title":"Targeted neuronal death affects neuronal replacement and vocal behavior in adult songbirds","volume":"25","author":"C Scharff","year":"2000","journal-title":"Neuron"},{"issue":"24","key":"pone.0314690.ref090","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.1523\/JNEUROSCI.22-24-10864.2002","article-title":"Vocal control neuron incorporation decreases with age in the adult zebra finch","volume":"22","author":"N Wang","year":"2002","journal-title":"J Neurosci"},{"issue":"13","key":"pone.0314690.ref091","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/dneu.20520","article-title":"Increasing stereotypy in adult zebra finch song correlates with a declining rate of adult neurogenesis","volume":"67","author":"CL Pytte","year":"2007","journal-title":"Dev Neurobiol"},{"issue":"1","key":"pone.0314690.ref092","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0016-6480(90)90051-M","article-title":"Sex steroid levels in developing and adult male and female zebra finches (Poephila guttata)","volume":"78","author":"E Adkins-Regan","year":"1990","journal-title":"Gen Comp Endocrinol"},{"key":"pone.0314690.ref093","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2202-7-77","article-title":"Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation","volume":"7","author":"T Pl\u00fcmpe","year":"2006","journal-title":"BMC Neurosci"},{"issue":"4","key":"pone.0314690.ref094","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1152\/jn.1998.80.4.1828","article-title":"Multiple cell types distinguished by physiological, pharmacological, and anatomic properties in nucleus HVc of the adult zebra finch","volume":"80","author":"P Dutar","year":"1998","journal-title":"J Neurophysiol"},{"issue":"8","key":"pone.0314690.ref095","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1523\/JNEUROSCI.3726-04.2005","article-title":"The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways","volume":"25","author":"R Mooney","year":"2005","journal-title":"J Neurosci"},{"issue":"5","key":"pone.0314690.ref096","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1152\/jn.00162.2013","article-title":"Electrophysiological characterization and computational models of HVC neurons in the zebra finch","volume":"110","author":"A Daou","year":"2013","journal-title":"J Neurophysiol"},{"issue":"15","key":"pone.0314690.ref097","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/cne.22383","article-title":"New brain pathways found in the vocal control system of a songbird","volume":"518","author":"E Akutagawa","year":"2010","journal-title":"J Comp Neurol"},{"issue":"7","key":"pone.0314690.ref098","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nn.4563","article-title":"Identification of a motor-to-auditory pathway important for vocal learning","volume":"20","author":"TF Roberts","year":"2017","journal-title":"Nat Neurosci"},{"issue":"6530","key":"pone.0314690.ref099","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd9704","article-title":"Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits","volume":"371","author":"BM Colquitt","year":"2021","journal-title":"Science"},{"issue":"5","key":"pone.0314690.ref100","doi-asserted-by":"crossref","first-page":"e0196387","DOI":"10.1371\/journal.pone.0196387","article-title":"Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms","volume":"13","author":"RA Carson","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"pone.0314690.ref101","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yexcr.2004.06.029","article-title":"Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation","volume":"300","author":"C Fern\u00e1ndez","year":"2004","journal-title":"Exp Cell Res"},{"issue":"8","key":"pone.0314690.ref102","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10080304","article-title":"Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds","author":"C Tonini","year":"2020","journal-title":"Metabolites"},{"issue":"3","key":"pone.0314690.ref103","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/jnc.15834","article-title":"Fundamental neurochemistry review: Old brain stories - Influence of age and sex on the neurodegeneration-associated lipid changes","volume":"166","author":"L Cuenca-Bermejo","year":"2023","journal-title":"J Neurochem"},{"issue":"10","key":"pone.0314690.ref104","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1089\/neu.2010.1330","article-title":"Injury-induced regulation of steroidogenic gene expression in the cerebellum","volume":"27","author":"A Mirzatoni","year":"2010","journal-title":"J Neurotrauma"},{"key":"pone.0314690.ref105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2010.07.027","article-title":"Steroidal and gonadal effects on neural cell proliferation in vitro in an adult songbird","volume":"1351","author":"A Mirzatoni","year":"2010","journal-title":"Brain Res"},{"issue":"1","key":"pone.0314690.ref106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bja\/aep149","article-title":"Statins for all: the new premed?","volume":"103","author":"ZL Brookes","year":"2009","journal-title":"Br J Anaesth"},{"issue":"6","key":"pone.0314690.ref107","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1536\/ihj.54.371","article-title":"Prophylactic statin administration may prevent shortening of the fibrillation cycle length in patients with new-onset atrial fibrillation","volume":"54","author":"J Oikawa","year":"2013","journal-title":"Int Heart J"},{"issue":"2 Pt 1","key":"pone.0314690.ref108","first-page":"349","article-title":"Pravastatin for the prevention of preeclampsia in high-risk pregnant women","volume":"121","author":"Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric--Fetal Pharmacology Research Units Network","year":"2013","journal-title":"Obstet Gynecol"},{"key":"pone.0314690.ref109","doi-asserted-by":"crossref","first-page":"106652","DOI":"10.1016\/j.eplepsyres.2021.106652","article-title":"Statin use for the prevention of seizure and epilepsy in the patients at risk: A systematic review and meta-analysis of cohort studies","volume":"174","author":"Y Guo","year":"2021","journal-title":"Epilepsy Res"},{"issue":"7","key":"pone.0314690.ref110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.biopsych.2022.03.009","article-title":"Associations Between Statin Use and Negative Affective Bias During COVID-19: An Observational, Longitudinal UK Study Investigating Depression Vulnerability","volume":"92","author":"AL Gillespie","year":"2022","journal-title":"Biol Psychiatry"},{"issue":"2","key":"pone.0314690.ref111","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3233\/JAD-2010-101179","article-title":"Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death","volume":"23","author":"S Sierra","year":"2011","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"pone.0314690.ref112","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1620\/tjem.204.299","article-title":"Hypolipidemic drugs can change the composition of rat brain lipids","volume":"204","author":"M Vecka","year":"2004","journal-title":"Tohoku J Exp Med"},{"issue":"5","key":"pone.0314690.ref113","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1471-4159.2010.07017.x","article-title":"Cholesterol asymmetry in synaptic plasma membranes","volume":"116","author":"WG Wood","year":"2011","journal-title":"J Neurochem"},{"issue":"8","key":"pone.0314690.ref114","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.bpj.2013.08.042","article-title":"The structural basis of cholesterol accessibility in membranes","volume":"105","author":"BN Olsen","year":"2013","journal-title":"Biophys J"},{"issue":"2","key":"pone.0314690.ref115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0033583500001797","article-title":"Phase transitions and fluidity characteristics of lipids and cell membranes","volume":"8","author":"D Chapman","year":"1975","journal-title":"Q Rev Biophys"},{"issue":"12","key":"pone.0314690.ref116","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00018-018-2789-9","article-title":"Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view","volume":"75","author":"G Jaipuria","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"pone.0314690.ref117","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bpj.2018.11.3127","article-title":"Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1","volume":"116","author":"A Krishna","year":"2018","journal-title":"Biophys J"},{"issue":"11","key":"pone.0314690.ref118","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.bpj.2018.10.024","article-title":"Spatially Resolving the Condensing Effect of Cholesterol in Lipid Bilayers","volume":"115","author":"F Leeb","year":"2018","journal-title":"Biophys J"},{"issue":"2","key":"pone.0314690.ref119","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0028-3908(00)00159-3","article-title":"Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones","volume":"40","author":"T Sooksawate","year":"2001","journal-title":"Neuropharmacology"},{"issue":"Pt 13","key":"pone.0314690.ref120","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1242\/jcs.001370","article-title":"The effect of cellular cholesterol on membrane-cytoskeleton adhesion","volume":"120","author":"M Sun","year":"2007","journal-title":"J Cell Sci"},{"issue":"2","key":"pone.0314690.ref121","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1471-4159.2001.00063.x","article-title":"Cholesterol-dependent modulation of tau phosphorylation in cultured neurons","volume":"76","author":"QW Fan","year":"2001","journal-title":"J Neurochem"},{"issue":"1","key":"pone.0314690.ref122","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1046\/j.0022-3042.2001.00686.x","article-title":"Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons","volume":"80","author":"Q-W Fan","year":"2002","journal-title":"J Neurochem"},{"issue":"1","key":"pone.0314690.ref123","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1460-9568.2003.02433.x","article-title":"Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer\u2019s disease","volume":"17","author":"V Meske","year":"2003","journal-title":"Eur J Neurosci"},{"issue":"15","key":"pone.0314690.ref124","doi-asserted-by":"crossref","first-page":"R677\u201391","DOI":"10.1016\/j.cub.2015.06.020","article-title":"Coordinating neuronal actin-microtubule dynamics","volume":"25","author":"CH Coles","year":"2015","journal-title":"Curr Biol"},{"issue":"16","key":"pone.0314690.ref125","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1021\/acs.jpclett.4c00332","article-title":"Dehydration of Lipid Membranes Drives Redistribution of Cholesterol Between Lateral Domains","volume":"15","author":"H Orlikowska-Rzeznik","year":"2024","journal-title":"J Phys Chem Lett"},{"issue":"3","key":"pone.0314690.ref126","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000447048","article-title":"Adult Neurogenesis in the Songbird: Region-Specific Contributions of New Neurons to Behavioral Plasticity and Stability","volume":"87","author":"CL Pytte","year":"2016","journal-title":"Brain Behav Evol"},{"key":"pone.0314690.ref127","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1196\/annals.1298.024","article-title":"Neuron addition and loss in the song system: regulation and function","volume":"1016","author":"L Wilbrecht","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"5-6","key":"pone.0314690.ref128","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/FBP.0b013e328356c3f2","article-title":"The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet","volume":"23","author":"\u00d6 D Can","year":"2012","journal-title":"Behav Pharmacol"},{"issue":"12","key":"pone.0314690.ref129","doi-asserted-by":"crossref","first-page":"13280","DOI":"10.1096\/fj.201901002R","article-title":"Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia","volume":"33","author":"LJ Trigiani","year":"2019","journal-title":"FASEB J"},{"issue":"4","key":"pone.0314690.ref130","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/ijms19041106","article-title":"A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome","volume":"19","author":"K Bimbova","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"pone.0314690.ref131","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.01.033","article-title":"The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia\/Reperfusion Injury","volume":"27","author":"Y Liu","year":"2018","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"pone.0314690.ref132","article-title":"Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage","volume":"38","author":"W Qi","year":"2018","journal-title":"Biosci Rep"},{"issue":"6","key":"pone.0314690.ref133","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4103\/1673-5374.184498","article-title":"Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury","volume":"11","author":"S Gao","year":"2016","journal-title":"Neural Regen Res"},{"issue":"6","key":"pone.0314690.ref134","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s11011-017-0091-4","article-title":"Mevastatin promotes neuronal survival against A\u03b2-induced neurotoxicity through AMPK activation","volume":"32","author":"E Kornelius","year":"2017","journal-title":"Metab Brain Dis"},{"issue":"1","key":"pone.0314690.ref135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13018-017-0536-9","article-title":"Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions","volume":"12","author":"H-M Sohn","year":"2017","journal-title":"J Orthop Surg Res"},{"issue":"5\u20136","key":"pone.0314690.ref136","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000503865","article-title":"Lovastatin Prevents Depressive Behaviors and Increased Hippocampal Neurogenesis in Streptozotocin-Induced Diabetic Mice","volume":"105","author":"C-R Tang","year":"2020","journal-title":"Pharmacology"},{"issue":"2","key":"pone.0314690.ref137","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1159\/000488630","article-title":"Simvastatin Attenuates Neurogenetic Damage and Improves Neurocongnitive Deficits Induced by Isoflurane in Neonatal Rats","volume":"46","author":"N Wang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"pone.0314690.ref138","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.stemcr.2013.11.002","article-title":"Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt\/\u03b2-catenin signaling","volume":"2","author":"NC Robin","year":"2014","journal-title":"Stem Cell Reports"},{"issue":"2","key":"pone.0314690.ref139","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/00016480802163358","article-title":"Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells","volume":"129","author":"DS Park","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"pone.0314690.ref140","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00018-005-5298-6","article-title":"Isoprenylated proteins","volume":"63","author":"SJ McTaggart","year":"2006","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"pone.0314690.ref141","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00018-013-1519-6","article-title":"Small Rho GTPases in the control of cell shape and mobility","volume":"71","author":"A Murali","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"pone.0314690.ref142","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainresbull.2017.03.003","article-title":"Crosstalk between glia, extracellular matrix and neurons","volume":"136","author":"I Song","year":"2018","journal-title":"Brain Res 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