{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:07:05Z","timestamp":1775909225770,"version":"3.50.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The 2024 Sapporo Bioscience Foundation"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K19321"],"award-info":[{"award-number":["20K19321"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K2082"],"award-info":[{"award-number":["24K2082"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19760"],"award-info":[{"award-number":["22K19760"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009036","name":"Strategic International Collaborative Research Program","doi-asserted-by":"publisher","award":["JPMJSC2308"],"award-info":[{"award-number":["JPMJSC2308"]}],"id":[{"id":"10.13039\/501100009036","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The 30th society for Research on Umami Taste"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Osteosarcopenia is a combination of sarcopenia and osteoporosis that increases mortality rates among older people compared with either alone. This study aimed to identify the contribution of osteosarcopenia to the development and severity of dysphagia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We retrospectively reviewed the medical charts of 211 patients aged \u2265 65 years who were referred to the dysphagia rehabilitation team. Based on Functional Oral Intake Scale (FOIS) scores, we classified the patients with (FOIS scores 1\u20135) and without (FOIS scores 6, 7) dysphagia as Type A and those with (FOIS scores 1, 2) and without (FOIS score 3\u20137) enteral feeding as Type B. Based on chest computed tomography (CT) findings we then defined patients with T4 (MI) and pectoralis (PMI) muscle indexes, L1 attenuation, and T4MI, PMI, and L1 attenuation below the cutoff values as having sarcopenia, osteoporosis, and osteosarcopenia, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The FOIS scores were significantly lower among patients with osteosarcopenia than among those without sarcopenia or osteoporosis. Moreover, PMI and FOIS scores significantly and positively correlated, and PMI was significantly lower in the group with, than without, enteral feeding. Osteoporosis and osteosarcopenia were significant in the patients who were fed enterally (p = 0.032 and 0.047, respectively).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Patients with sarcopenia and osteoporosis undergoing swallowing rehabilitation tended to have severe dysphagia that required much medical attention.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0315091","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:45:32Z","timestamp":1734633932000},"page":"e0315091","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of osteosarcopenia on feeding status in hospitalized patients with suspected dysphagia"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1278-0717","authenticated-orcid":true,"given":"Midori","family":"Miyagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-649X","authenticated-orcid":true,"given":"Satoru","family":"Ebihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"1","key":"pone.0315091.ref001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/ggi.13839","article-title":"Association between sarcopenia and pneumonia in older people","volume":"20","author":"T Okazaki","year":"2020","journal-title":"Geriatr Gerontol Int"},{"issue":"10","key":"pone.0315091.ref002","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/ggi.14466","article-title":"Functional prognosis in patients with sarcopenic dysphagia: An observational cohort study from the Japanese sarcopenic dysphagia database","volume":"22","author":"T Nagai","year":"2022","journal-title":"Geriatr Gerontol Int"},{"issue":"3","key":"pone.0315091.ref003","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. Postmenopausal osteoporosis","volume":"374","author":"DM Black","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"pone.0315091.ref004","doi-asserted-by":"crossref","first-page":"253","DOI":"10.12968\/hmed.2018.79.5.253","article-title":"Osteosarcopenia","volume":"79","author":"J Paintin","year":"2018","journal-title":"Br J Hosp Med (Lond)"},{"issue":"4","key":"pone.0315091.ref005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.afos.2022.11.001","article-title":"Lower SMI is a risk factor for dysphagia in Japanese hospitalized patients with osteoporotic vertebral and hip fracture: A retrospective study","volume":"8","author":"K Suseki","year":"2022","journal-title":"Osteoporos Sarcopenia."},{"issue":"5","key":"pone.0315091.ref006","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40520-015-0494-1","article-title":"Osteosarcopenia is more than sarcopenia and osteopenia alone","volume":"28","author":"FiAT intervention group","year":"2016","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"pone.0315091.ref007","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"3","key":"pone.0315091.ref008","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"LK Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"issue":"4","key":"pone.0315091.ref009","doi-asserted-by":"crossref","first-page":"e010554","DOI":"10.1161\/JAHA.118.010554","article-title":"Axial muscle size as a strong predictor of death in subjects with and without heart failure","volume":"8","author":"A Kumar","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"pone.0315091.ref010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12931-019-1001-6","article-title":"Thoracic skeletal muscle quantification: Low muscle mass is related with worse prognosis in idiopathic pulmonary fibrosis patients","volume":"20","author":"SW Moon","year":"2019","journal-title":"Respir Res"},{"issue":"1","key":"pone.0315091.ref011","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/s41598-020-59100-5","article-title":"Early decrease in erector spinae muscle area and future risk of mortality in idiopathic pulmonary fibrosis","volume":"10","author":"A Nakano","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0315091.ref012","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1513\/AnnalsATS.201507-446OC","article-title":"Quantitative assessment of erector spinae muscles in patients with chronic obstructive pulmonary disease. Novel chest computed tomography-derived index for prognosis","volume":"13","author":"K Tanimura","year":"2016","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"pone.0315091.ref013","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jcsm.12946","article-title":"Reference values of skeletal muscle area for diagnosis of sarcopenia using chest computed tomography in Asian general population","volume":"13","author":"SW Moon","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"10","key":"pone.0315091.ref014","doi-asserted-by":"crossref","first-page":"e0240084","DOI":"10.1371\/journal.pone.0240084","article-title":"Opportunistic use of chest CT for screening osteoporosis and predicting the risk of incidental fracture in breast cancer patients: A retrospective longitudinal study","volume":"15","author":"SH Park","year":"2020","journal-title":"PLoS 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Eslick","year":"2008","journal-title":"Aliment Pharmacol The"},{"issue":"1","key":"pone.0315091.ref018","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12931-021-01621-2","article-title":"The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD","volume":"22","author":"T Shirahata","year":"2021","journal-title":"Respir Res"},{"issue":"9","key":"pone.0315091.ref019","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/1756-185X.14795","article-title":"Association between computed tomography\u2010assessed sarcopenia and mortality in patients with anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis","volume":"26","author":"SS Ahn","year":"2023","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"pone.0315091.ref020","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1148\/radiol.2019190434","article-title":"Screening of Bone Density at CT: An overlooked 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Saeki","year":"2023","journal-title":"BMC Gastroenterol"},{"key":"pone.0315091.ref024","doi-asserted-by":"crossref","first-page":"1181139","DOI":"10.3389\/fendo.2023.1181139","article-title":"Sarcopenia and osteosarcopenia among patients undergoing hemodialysis","volume":"14","author":"T Xiang","year":"2023","journal-title":"Front Endocrinol"},{"issue":"1","key":"pone.0315091.ref025","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00455-020-10120-3","article-title":"Relationship between dysphagia and sarcopenia with comprehensive geriatric evaluation","volume":"36","author":"F F\u0131rat Ozer","year":"2021","journal-title":"Dysphagia"},{"issue":"8","key":"pone.0315091.ref026","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s12603-018-1055-z","article-title":"Systematic review and meta-analysis of the association between sarcopenia and dysphagia","volume":"22","author":"WT Zhao","year":"2018","journal-title":"J Nutr Health Aging"},{"issue":"8","key":"pone.0315091.ref027","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1007\/s00405-023-08014-9","article-title":"Role of sarcopenia on survival and treatment-related toxicity in head and neck cancer: a narrative review of current evidence and future perspectives","volume":"280","author":"E Erul","year":"2023","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"pone.0315091.ref028","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2217\/bmm-2022-0748","article-title":"Evaluation of sarcopenia as a prognostic biomarker in locally advanced head and neck squamous cell carcinoma","volume":"17","author":"E Erul","year":"2023","journal-title":"Biomark Med"},{"key":"pone.0315091.ref029","doi-asserted-by":"crossref","first-page":"3548284","DOI":"10.1155\/2019\/3548284","article-title":"Assessment of body composition in health and disease using bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DXA): A critical overview","volume":"2019","author":"M Marra","year":"2019","journal-title":"Contrast Media Mol Imaging"}],"container-title":["PLOS 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