{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:09:25Z","timestamp":1770977365375,"version":"3.50.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Individuals with Parkinson\u2019s Disease (PD) often experience not only physical symptoms but also a higher prevalence of psychological issues, including depression, anxiety, schizophrenia, and psychotic symptoms, compared to the general population. The relationship between these physical and psychological symptoms remains poorly understood, particularly in relation to commonly used measures of physical function and a wider variety of psychological symptoms. Investigating this link is essential for optimising patient care. This cohort study is registered with OSF (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/osf.io\/c7tvd\" xlink:type=\"simple\">https:\/\/osf.io\/c7tvd<\/jats:ext-link>).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The primary aim of this study is to investigate the association between physical and psychological symptoms in PD. We will focus specifically on measures of physical function such as balance and mobility, assess the similarities between physiotherapist and participant-rated measures, and monitor changes over time.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This cohort study plans to recruit 30 participants with PD, who will be monitored over a 12-month period. Data will be collected at baseline and completion, providing two data points per participant. Selected outcome measures will include physical function (objective measures), non-motor symptoms, participants perceived function, and engagement in physical activity. Correlations between outcomes will be analysed, and multivariate regression modelling may be employed for time-series analysis to evaluate how relationships change over time. Descriptive summaries of all outcomes will be presented in tables.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Ethical approval for this study was obtained on 15<jats:sup>th<\/jats:sup> July 2024, with participant recruitment scheduled to begin in October 2024. Data collection is expected to conclude by August 2026, with final results anticipated within six months of study completion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study will be the first to monitor this specific set of physical and psychological outcomes over time in individuals with PD. The findings are expected to provide valuable insights into the relationship between these symptoms, informing future research and potentially leading to larger-scale, multi-site studies conducted over extended assessment periods.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0315345","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T18:27:11Z","timestamp":1734373631000},"page":"e0315345","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psycho-physical interactions in Parkinson\u2019s Disease: Protocol for a prospective observational cohort study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-5422","authenticated-orcid":true,"given":"Philip","family":"Hodgson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-8780","authenticated-orcid":true,"given":"Charikleia","family":"Sinani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divine","family":"Charura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"1","key":"pone.0315345.ref001","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"D Aarsland","year":"2021","journal-title":"Nature Reviews Disease Primers"},{"key":"pone.0315345.ref002","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/B978-0-12-374028-1.00024-5","volume-title":"Parkinson\u2019s Disease.","author":"EB Penney","year":"2008"},{"issue":"8","key":"pone.0315345.ref003","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"O-B Tysnes","year":"2017","journal-title":"Journal of Neural Transmission"},{"issue":"1","key":"pone.0315345.ref004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","article-title":"The Parkinson Pandemic-A Call to Action","volume":"75","author":"ER Dorsey","year":"2018","journal-title":"JAMA Neurol"},{"key":"pone.0315345.ref005","doi-asserted-by":"crossref","first-page":"j1951","DOI":"10.1136\/bmj.j1951","article-title":"Parkinson\u2019s disease: summary of updated NICE guidance","volume":"358","author":"G Rogers","year":"2017","journal-title":"Bmj"},{"key":"pone.0315345.ref006","article-title":"Parkinson\u2019s symptoms | Parkinson\u2019s UK [Internet].","author":"UK Parkinson\u2019s","year":"2019","journal-title":"Parkinsons.org.uk"},{"key":"pone.0315345.ref007","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1038\/npjparkd.2015.11","article-title":"Why do patients with Parkinson\u2019s disease fall? A cross-sectional analysis of possible causes of falls.","volume":"1","author":"A Schrag","year":"2015","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"pone.0315345.ref008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/0976-3147.143197","article-title":"Psychiatric aspects of Parkinson\u2019s disease","volume":"6","author":"S Grover","year":"2015","journal-title":"J Neurosci Rural Pract"},{"issue":"1","key":"pone.0315345.ref009","first-page":"27","article-title":"[Prevalence of mental disorders in persons with Parkinson\u2019s disease].","volume":"142","author":"C de Rijk","year":"1998","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"1","key":"pone.0315345.ref010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrneurol.2011.189","article-title":"Depression in Parkinson disease\u2014epidemiology, mechanisms and management.","volume":"8","author":"D Aarsland","year":"2011","journal-title":"Nat Rev Neurol."},{"issue":"8","key":"pone.0315345.ref011","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/mds.26643","article-title":"Prevalence of anxiety in Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"31","author":"MP Broen","year":"2016","journal-title":"Mov Disord"},{"key":"pone.0315345.ref012","volume-title":"A survey carried out for NHS Digital by NatCen Social Research and the Department of Health Sciences","author":"S McManus"},{"key":"pone.0315345.ref013","article-title":"Parkinson\u2019s disease in adults Online","author":"NICE","journal-title":":"},{"key":"pone.0315345.ref014","article-title":"The Improving Access to Psychological Therapies (IAPT) Pathway for People with Long-term Physical Health Conditions and Medically Unexplained Symptoms Online","author":"NHS England, NHS Improvement"},{"key":"pone.0315345.ref015","year":"2018","journal-title":"Internet]. Parkinson\u2019s UK"},{"key":"pone.0315345.ref016","first-page":"42","article-title":"The relationship between physical and mental health: A mediation analysis. Social Science &","volume":"195","author":"J Ohrnberger","year":"2017","journal-title":"Medicine"},{"issue":"4","key":"pone.0315345.ref017","doi-asserted-by":"crossref","first-page":"e0249390","DOI":"10.1371\/journal.pone.0249390","article-title":"What is the lived experience of anxiety for people with Parkinson\u2019s? 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CNS Neuroscience &","volume":"30","author":"P Hodgson","year":"2024","journal-title":"Therapeutics"},{"issue":"1","key":"pone.0315345.ref026","first-page":"40","article-title":"Self-Reported Depression and Anxiety are Correlated with Functional Disability in Parkinson\u2019s Disease.","volume":"49","author":"A Still","year":"2021","journal-title":"New Zealand Journal of Physiotherapy"},{"issue":"1","key":"pone.0315345.ref027","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12883-021-02493-1","article-title":"Evolution and prediction of mismatch between observed and perceived upper limb function after stroke: a prospective, longitudinal, observational cohort study.","volume":"21","author":"B Essers","year":"2021","journal-title":"BMC Neurol."},{"key":"pone.0315345.ref028","first-page":"43","article-title":"European Physiotherapy Guideline for Parkinson\u2019s Disease.","author":"S Keus","year":"2019"},{"issue":"3","key":"pone.0315345.ref029","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"AJ Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"pone.0315345.ref030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/hex.13165","article-title":"Inclusion under the Mental Capacity Act (2005): A review of research policy guidance and governance structures in England and Wales.","volume":"24","author":"H Ryan","year":"2021","journal-title":"Health Expectations"},{"issue":"80","key":"pone.0315345.ref031","first-page":"61","article-title":"Advances in the mechanisms of Parkinson\u2019s disease.","volume":"15","author":"CM Tolleson","year":"2013","journal-title":"Discov Med."},{"issue":"1","key":"pone.0315345.ref032","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0031-1298595","article-title":"Assessing bias: the importance of considering confounding.","volume":"3","author":"AC Skelly","year":"2012","journal-title":"Evid Based Spine Care J"},{"issue":"1","key":"pone.0315345.ref033","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02294183","article-title":"Sample size requirements for estimating pearson, kendall and spearman correlations.","volume":"65","author":"DG Bonett","year":"2000","journal-title":"Psychometrika."},{"issue":"4","key":"pone.0315345.ref034","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses.","volume":"41","author":"F Faul","year":"2009","journal-title":"Behavior Research 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Epidemiol"},{"issue":"6","key":"pone.0315345.ref038","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ageing\/afi196","article-title":"Development and initial validation of the Falls Efficacy Scale-International (FES-I).","volume":"34","author":"L Yardley","year":"2005","journal-title":"Age Ageing."},{"issue":"11","key":"pone.0315345.ref039","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1017\/S1368980010000157","article-title":"The International Physical Activity Questionnaire modified for the elderly: aspects of validity and feasibility.","volume":"13","author":"A Hurtig-Wennl\u00f6f","year":"2010","journal-title":"Public Health Nutrition."},{"issue":"9","key":"pone.0315345.ref040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ptj\/80.9.896","article-title":"Predicting the Probability for Falls in Community-Dwelling Older Adults Using the Timed Up & Go Test.","volume":"80","author":"A Shumway-Cook","year":"2000","journal-title":"Physical Therapy."},{"issue":"6","key":"pone.0315345.ref041","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale.","volume":"67","author":"AS Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"4","key":"pone.0315345.ref042","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00415-011-6254-z","article-title":"Psychometric performance of a generic walking scale (Walk-12G) in multiple sclerosis and Parkinson\u2019s disease.","volume":"259","author":"S Bladh","year":"2012","journal-title":"J Neurol"},{"issue":"8","key":"pone.0315345.ref043","first-page":"783","article-title":"The six-minute walk test","volume":"48","author":"PL Enright","year":"2003","journal-title":"Respir Care"},{"issue":"2","key":"pone.0315345.ref044","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-1781(91)90040-V","article-title":"Reliability and validity of the Apathy Evaluation Scale.","volume":"38","author":"RS Marin","year":"1991","journal-title":"Psychiatry Res."},{"issue":"10","key":"pone.0315345.ref045","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/ptj\/85.10.1034","article-title":"Clinical Measurement of Sit-to-Stand Performance in People With Balance Disorders: Validity of Data for the Five-Times-Sit-to-Stand Test.","volume":"85","author":"SL Whitney","year":"2005","journal-title":"Physical Therapy."},{"issue":"10","key":"pone.0315345.ref046","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L).","volume":"20","author":"M Herdman","year":"2011","journal-title":"Qual Life Res."},{"issue":"6","key":"pone.0315345.ref047","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3138\/ptc.41.6.304","article-title":"Measuring balance in the elderly: preliminary development of an instrument","volume":"41","author":"K Berg","year":"1989","journal-title":"Physiotherapy Canada"},{"key":"pone.0315345.ref048","doi-asserted-by":"crossref","first-page":"810038","DOI":"10.3389\/fneur.2022.810038","article-title":"Characterization of Parkinson\u2019s Disease Subtypes and Related Attributes.","volume":"13","author":"S Shakya","year":"2022","journal-title":"Front Neurol."},{"issue":"2","key":"pone.0315345.ref049","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1976\/ad1e77","article-title":"Brain connectivity for subtypes of parkinson\u2019s disease using structural MRI","volume":"10","author":"T Samantaray","year":"2024","journal-title":"Biomed Phys Eng Express"},{"key":"pone.0315345.ref050","doi-asserted-by":"crossref","first-page":"1040293","DOI":"10.3389\/fnagi.2022.1040293","article-title":"Subtyping of early-onset Parkinson\u2019s disease using cluster analysis: A large cohort study.","volume":"14","author":"Z Zhou","year":"2022","journal-title":"Front Aging 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