{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:40:14Z","timestamp":1777372814981,"version":"3.51.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The performance of digital breast tomosynthesis (DBT) alone, digital mammography (DM) plus DBT, and synthesized mammography (SM) plus DBT, in comparison to DM in breast cancer screening, remains a topic of ongoing debate. The effectiveness of these modalities in reducing interval cancer rates (ICR) is particularly contentious.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>A database of data was searched for articles published until July 2024. Initially, the pooled sensitivity and specificity of DBT (DBT alone, DM\/DBT, and SM\/DBT) and DM were estimated. Additionally, the sensitivity of breast cancer screening and ICR for DBT alone, DM\/DBT, and SM\/DBT compared to DM. The characteristics of interval breast cancer were compared with those screening BC, alongside differences across various screening methods.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Eleven studies comparing DBT and DM were included. The sensitivity of DBT was higher than that of DM, with rates of 86% (95%CI: 81, 90) and 80% (95%CI: 76, 84), respectively. The specificities of both modalities were similar, recorded at 96% (95%CI: 95, 98) and 96% (95%CI: 95, 97), respectively. In comparison to DM, the screening sensitivities of DBT, DM\/DBT, and SM\/DBT were increased by 4.33% (95% CI: 1.52, 7.13), 6.29% (95% CI: 2.55, 10.03), and 5.22% (95% CI: 1.35, 9.10), respectively; however, the difference in the ICR was not statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>DBT offers advantages in enhancing the sensitivity of breast cancer screening; however, its impact on ICR remains uncertain. Consequently, further research is necessary to comprehensively evaluate both the effectiveness of screening and the potential risks associated with DBT.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0315466","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T18:41:12Z","timestamp":1738348872000},"page":"e0315466","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of digital breast tomosynthesis on screening performance and interval cancer rates compared to digital mammography: A 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