{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:02:00Z","timestamp":1767178920331,"version":"build-2238731810"},"reference-count":14,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012834","name":"Gifu University","doi-asserted-by":"publisher","award":["No specific award number"],"award-info":[{"award-number":["No specific award number"]}],"id":[{"id":"10.13039\/100012834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Computed tomographic colonography (CTC) is crucial for colorectal cancer screening and secondary examinations, often revealing extracolonic findings with unclear significance. This study retrospectively evaluated the impact of such findings on the prognosis and management of 103 patients (mean observation period [OP]: 2183 days), categorized according to the CT Colonography Reporting and Data System (C-RADS). The distributions were 17% (mean OP: 2,821 days) for E1, 38% for E2 (2,759 days), 6% for E3 (2,150 days), and 39% for E4 (1,338 days). Eighteen patients were further examined, but no treatment-related changes were observed in the E2 or E3 cases. Six of nine E4 patients responded to treatment (mean OP: 1,286 days). Kaplan\u2013Meier analysis revealed worse prognosis for E4 (mean survival: 10.1 years) than for E1\u2013E3 combined (5.6 years) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). E4 findings are key in guiding treatment. The concordance rate between the clinical (Past E) and revised (Revised E) categories was high (0.83, 95% confidence interval: 0.77\u20130.88). The prognoses differed significantly between Revised E1\u2013E3 (mean survival: 10.0 years) and Revised E4 (6.2 years) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). Although E4 significantly affects prognosis, E2 and E3 had limited effects on treatment, highlighting the need for further study to improve diagnostic accuracy.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0315601","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:23:13Z","timestamp":1740748993000},"page":"e0315601","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognosis of extracolonic findings on clinical computed tomographic colonography: A single-center experience"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-0794","authenticated-orcid":true,"given":"Hideto","family":"Tomimatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5983-1089","authenticated-orcid":true,"given":"Taketo","family":"Suto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"12","key":"pone.0315601.ref001","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa0800996","article-title":"Accuracy of CT colonography for detection of large adenomas and cancers","volume":"359","author":"CD Johnson","year":"2008","journal-title":"N Engl J Med"},{"issue":"23","key":"pone.0315601.ref002","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1001\/jama.2009.832","article-title":"Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer","volume":"301","author":"D Regge","year":"2009","journal-title":"JAMA"},{"issue":"1","key":"pone.0315601.ref003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/ajg.2016.478","article-title":"Accuracy of CT colonography for detection of polypoid and nonpolypoid neoplasia by gastroenterologists and radiologists: a nationwide multicenter study in Japan","volume":"112","author":"K Nagata","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"pone.0315601.ref004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1148\/radiol.2361041926","article-title":"CT colonography reporting and data system: a consensus proposal","volume":"236","author":"ME Zalis","year":"2005","journal-title":"Radiology"},{"issue":"12","key":"pone.0315601.ref005","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1055\/a-1258-4819","article-title":"Imaging alternatives to colonoscopy: CT colonography and colon capsule. European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline - Update 2020","volume":"52","author":"C Spada","year":"2020","journal-title":"Endoscopy"},{"issue":"19","key":"pone.0315601.ref006","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/jama.2021.6238","article-title":"Screening for colorectal cancer: US Preventive Services Task Force Recommendation statement","volume":"325","author":"Force US Preventive Services Task","year":"2021","journal-title":"JAMA"},{"issue":"2","key":"pone.0315601.ref007","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2214\/AJR.15.15193","article-title":"Potentially important extracolonic findings at screening CT colonography: incidence and outcomes data from a clinical screening program","volume":"206","author":"BD Pooler","year":"2016","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"pone.0315601.ref008","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2214\/AJR.16.16275","article-title":"Indeterminate but likely unimportant extracolonic findings at screening CT Colonography (C-RADS Category E3): incidence and outcomes data from a clinical screening program","volume":"207","author":"BD Pooler","year":"2016","journal-title":"AJR Am J Roentgenol"},{"issue":"6","key":"pone.0315601.ref009","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00261-005-0328-2","article-title":"Virtual CT colectomy by three-dimensional imaging using multidetector-row CT for laparoscopic colorectal surgery","volume":"30","author":"M Matsuki","year":"2005","journal-title":"Abdom Imaging"},{"issue":"3","key":"pone.0315601.ref010","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1148\/radiol.2020202367","article-title":"MRI findings of liver parenchyma peripheral to colorectal liver metastasis: a potential predictor of long-term prognosis","volume":"297","author":"Y Nakai","year":"2020","journal-title":"Radiology"},{"issue":"1","key":"pone.0315601.ref011","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2214\/AJR.17.19495","article-title":"JOURNAL CLUB: extracolonic findings at CT colonography: systematic review and meta-analysis","volume":"211","author":"PJ Pickhardt","year":"2018","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"pone.0315601.ref012","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2214\/AJR.10.4907","article-title":"Radiation-related cancer risks from CT colonography screening: a risk-benefit analysis","volume":"196","author":"A Berrington de Gonz\u00e1lez","year":"2011","journal-title":"AJR Am J Roentgenol"},{"issue":"7","key":"pone.0315601.ref013","first-page":"441","article-title":"Technical basics and clinical benefits of photon-counting CT","volume":"58","author":"T Flohr","year":"2023","journal-title":"Invest Radiol"},{"issue":"1","key":"pone.0315601.ref014","doi-asserted-by":"crossref","first-page":"e0261527","DOI":"10.1371\/journal.pone.0261527","article-title":"Assessment of the use of computed tomography colonography in early detection of peritoneal metastasis in patients with gastric cancer: A prospective cohort study","volume":"17","author":"K Iwasaki","year":"2022","journal-title":"PLoS One"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0334534","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0315601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:23:24Z","timestamp":1740749004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0315601"}},"subtitle":[],"editor":[{"given":"Suvendu","family":"Maji","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0315601","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}