{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:30Z","timestamp":1792788750103,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The High-Level Talent Scientific Research Startup Fund of The Tenth Affiliated Hospital, Southern Medical University","award":["Grant No.G202410"],"award-info":[{"award-number":["Grant No.G202410"]}]},{"name":"Teaching Reform Research Program of Clinical Teaching Base of Guangdong Province","award":["\u30142022\u301521-2021JD066"],"award-info":[{"award-number":["\u30142022\u301521-2021JD066"]}]},{"name":"the Medical Scientific Research Foundation of Guangdong Province of China","award":["Grant No. A2022176"],"award-info":[{"award-number":["Grant No. A2022176"]}]},{"DOI":"10.13039\/501100021518","name":"Perry Cross Spinal Research Foundation","doi-asserted-by":"publisher","award":["2020LKSFG03B"],"award-info":[{"award-number":["2020LKSFG03B"]}],"id":[{"id":"10.13039\/501100021518","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Despite the availability of various treatment options, glioblastoma (GBM) remains an extremely aggressive form of glioma with a poor prognosis. In recent studies, regulatory cell death (RCD) has been identified as an effective mechanism to suppress glioma. Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. To determine whether CRLs and CRGs have prognostic significance, a GBM cohort in TCGA to build a novel cuproptosis-related risk model. Two high-risk CRLs (AC091182.2, AC005229.4) and their co-expression CRGs (\n                    <jats:italic>LIPT2<\/jats:italic>\n                    ,\n                    <jats:italic>GLS<\/jats:italic>\n                    ) were identified and verified to constitute an independent prognostic indicator of GBM. RT-qPCR analysis confirmed that the high-risk CRLs and CRGs were highly expressed in GBM cells compared to normal astrocytes. By constructing a mouse GBM model, high-risk CRLs and CRGs were found to be expressed at higher levels in tumor tissues. Furthermore, to verify whether these CRLs and CRGs are associated with GBM cuproptosis, cuproptosis cell models were constucted in GBM cell lines and astrocyte by using Elesclomol and CuCl\n                    <jats:sub>2<\/jats:sub>\n                    . It was found that the expression of high-risk CRLs and CRGs was decreased upon cuproptosis-induced in GBM cells. Interestingly, normal astrocytes were less sensitive than GBM cells to cuproptosis-inducing drugs, and the effects of the drugs on the expression of the CRLs and CRGs in normal astrocytes were opposite to that of in GBM cells. In conclusion, by constructing a novel cuproptosis-related risk model, two high-risk CRLs and CRGs were identified. Their specific pointing to GBM has been demonstrated through a variety of experiments. These CRLs and CRGs might serve as prognostic markers and indicators for GBM and provide theoretical support for future GBM treatment.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0315927","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:59:45Z","timestamp":1738850385000},"page":"e0315927","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment"],"prefix":"10.1371","volume":"20","author":[{"given":"Yajia","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-3384","authenticated-orcid":true,"given":"Hongwu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"pone.0315927.ref001","doi-asserted-by":"crossref","first-page":"15017","DOI":"10.1038\/nrdp.2015.17","article-title":"Glioma","volume":"1","author":"M Weller","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"pone.0315927.ref002","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"DN Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"pone.0315927.ref003","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmpb.2019.06.031","article-title":"Effect of fractal-shaped outer boundary of glioblastoma multiforme on drug delivery","volume":"178","author":"SE Samioti","year":"2019","journal-title":"Comput Methods Programs Biomed"},{"issue":"1","key":"pone.0315927.ref004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21873\/anticanres.11285","article-title":"Advances in experimental targeted therapy and immunotherapy for patients with glioblastoma multiforme","volume":"37","author":"Jr Polivka J","year":"2017","journal-title":"Anticancer Res"},{"issue":"7693","key":"pone.0315927.ref005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells","volume":"554","author":"S Mariathasan","year":"2018","journal-title":"Nature"},{"issue":"5","key":"pone.0315927.ref006","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/neuonc\/nov255","article-title":"Statistical considerations on prognostic models for glioma","volume":"18","author":"AM Molinaro","year":"2016","journal-title":"Neuro Oncol"},{"issue":"2","key":"pone.0315927.ref007","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1367-5931(99)00073-3","article-title":"Metals and neuroscience","volume":"4","author":"AI Bush","year":"2000","journal-title":"Curr Opin Chem Biol"},{"issue":"5 Suppl 1","key":"pone.0315927.ref008","doi-asserted-by":"crossref","first-page":"1579S","DOI":"10.1093\/jn\/133.5.1579S","article-title":"Integrating trace element metabolism from the cell to the whole organism","volume":"133","author":"DJ Thiele","year":"2003","journal-title":"J Nutr"},{"issue":"7","key":"pone.0315927.ref009","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/jn\/129.7.1251","article-title":"A delicate balance: homeostatic control of copper uptake and distribution","volume":"129","author":"MM Pe\u00f1a","year":"1999","journal-title":"J Nutr"},{"issue":"2","key":"pone.0315927.ref010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pharmthera.2011.10.006","article-title":"Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases","volume":"133","author":"W Zheng","year":"2012","journal-title":"Pharmacol Ther"},{"issue":"1","key":"pone.0315927.ref011","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12964-018-0277-3","article-title":"Copper signalling: causes and consequences","volume":"16","author":"J Kardos","year":"2018","journal-title":"Cell Commun Signal"},{"issue":"3","key":"pone.0315927.ref012","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s007020050026","article-title":"CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson\u2019s disease","volume":"107","author":"HJ Stuerenburg","year":"2000","journal-title":"J Neural Transm (Vienna)"},{"issue":"22","key":"pone.0315927.ref013","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.3390\/ijms232213850","article-title":"The role of copper homeostasis in brain disease","volume":"23","author":"Y An","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"23","key":"pone.0315927.ref014","doi-asserted-by":"crossref","first-page":"9259","DOI":"10.3390\/ijms21239259","article-title":"Copper dyshomeostasis in neurodegenerative diseases-therapeutic implications","volume":"21","author":"G Gromadzka","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"pone.0315927.ref015","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cr.2017.155","article-title":"Mitochondrial metabolism and cancer","volume":"28","author":"PE Porporato","year":"2018","journal-title":"Cell Res"},{"issue":"13","key":"pone.0315927.ref016","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1182\/blood-2014-08-594408","article-title":"AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress","volume":"125","author":"S Sriskanthadevan","year":"2015","journal-title":"Blood"},{"issue":"6586","key":"pone.0315927.ref017","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"P Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"7","key":"pone.0315927.ref018","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","article-title":"Mitochondrial metabolism promotes adaptation to proteotoxic stress","volume":"15","author":"P Tsvetkov","year":"2019","journal-title":"Nat Chem Biol"},{"issue":"1","key":"pone.0315927.ref019","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13046-021-02031-4","article-title":"Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth","volume":"40","author":"M Buccarelli","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"pone.0315927.ref020","doi-asserted-by":"crossref","first-page":"1082974","DOI":"10.3389\/fimmu.2023.1082974","article-title":"Construction and validation of a cuproptosis-related prognostic model for glioblastoma","volume":"14","author":"B Zhang","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"pone.0315927.ref021","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12967-023-03883-4","article-title":"EREG is the core onco-immunological biomarker of cuproptosis and mediates the cross-talk between VEGF and CD99 signaling in glioblastoma","volume":"21","author":"Y Zhou","year":"2023","journal-title":"J Transl Med"},{"key":"pone.0315927.ref022","doi-asserted-by":"crossref","first-page":"1244638","DOI":"10.3389\/fmed.2023.1244638","article-title":"Corrigendum: cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma","volume":"10","author":"H Lu","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"pone.0315927.ref023","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41388-022-02537-x","article-title":"CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1","volume":"42","author":"D Li","year":"2023","journal-title":"Oncogene"},{"issue":"9","key":"pone.0315927.ref024","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41419-020-02939-3","article-title":"MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p\/NRF2 axis in non-small cell lung cancer cells","volume":"11","author":"C Gai","year":"2020","journal-title":"Cell Death Dis"},{"key":"pone.0315927.ref025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"S H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"pone.0315927.ref026","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"1\u20134","key":"pone.0315927.ref027","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/biof.5520240130","article-title":"Copper related toxic effects on cellular protein metabolism in human astrocytes","volume":"24","author":"K Merker","year":"2005","journal-title":"Biofactors"},{"issue":"5","key":"pone.0315927.ref028","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.soncn.2018.10.001","article-title":"Epidemiology and Overview of Gliomas","volume":"34","author":"ME Davis","year":"2018","journal-title":"Semin Oncol Nurs"},{"issue":"1","key":"pone.0315927.ref029","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"X Tong","year":"2022","journal-title":"J Hematol Oncol"},{"issue":"1","key":"pone.0315927.ref030","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","article-title":"The role of necroptosis in cancer biology and therapy","volume":"18","author":"Y Gong","year":"2019","journal-title":"Mol Cancer"},{"issue":"5","key":"pone.0315927.ref031","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: a copper-triggered modality of mitochondrial cell death","volume":"32","author":"D Tang","year":"2022","journal-title":"Cell Res"},{"issue":"14","key":"pone.0315927.ref032","doi-asserted-by":"crossref","first-page":"904","DOI":"10.21037\/atm.2020.03.42","article-title":"Mitochondrial metabolism and cancer metastasis","volume":"8","author":"D Yu","year":"2020","journal-title":"Ann Transl Med"},{"issue":"1","key":"pone.0315927.ref033","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12943-019-1104-1","article-title":"TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2","volume":"19","author":"Y Shuai","year":"2020","journal-title":"Mol Cancer"},{"key":"pone.0315927.ref034","doi-asserted-by":"crossref","first-page":"963689720986071","DOI":"10.1177\/0963689720986071","article-title":"LncRNA PCAT1 Interacts with DKC1 to regulate proliferation, invasion and apoptosis in NSCLC cells via the VEGF\/AKT\/Bcl2\/Caspase9 pathway","volume":"30","author":"S-Y Liu","year":"2021","journal-title":"Cell Transplant"},{"issue":"11","key":"pone.0315927.ref035","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41419-021-04245-y","article-title":"A positive feedback loop of lncRNA-RMRP\/ZNRF3 axis and Wnt\/\u03b2-catenin signaling regulates the progression and temozolomide resistance in glioma","volume":"12","author":"T Liu","year":"2021","journal-title":"Cell Death Dis"},{"key":"pone.0315927.ref036","doi-asserted-by":"crossref","first-page":"1124439","DOI":"10.3389\/fgene.2023.1124439","article-title":"Identification of cuproptosis-related subtypes and the development of a prognostic model in glioma","volume":"14","author":"Z Wu","year":"2023","journal-title":"Front Genet"},{"key":"pone.0315927.ref037","doi-asserted-by":"crossref","first-page":"998236","DOI":"10.3389\/fimmu.2022.998236","article-title":"The cuproptosis-related signature associated with the tumor environment and prognosis of patients with glioma","volume":"13","author":"W Wang","year":"2022","journal-title":"Front Immunol"},{"key":"pone.0315927.ref038","doi-asserted-by":"crossref","first-page":"1016520","DOI":"10.3389\/fphar.2022.1016520","article-title":"Prognostic value of cuproptosis-related genes signature and its impact on the reshaped immune microenvironment of glioma","volume":"13","author":"S Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"pone.0315927.ref039","doi-asserted-by":"crossref","first-page":"963639","DOI":"10.3389\/fmolb.2023.963639","article-title":"Pan-cancer integrated bioinformatics analysis reveals cuproptosis related gene FDX1 is a potential prognostic and immunotherapeutic biomarker for lower-grade gliomas","volume":"10","author":"W Huang","year":"2023","journal-title":"Front Mol Biosci"},{"issue":"4","key":"pone.0315927.ref040","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.18632\/aging.202431","article-title":"Prognostic value of an autophagy-related long-noncoding-RNA signature for endometrial cancer","volume":"13","author":"X Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"pone.0315927.ref041","doi-asserted-by":"crossref","first-page":"647236","DOI":"10.3389\/fonc.2021.647236","article-title":"Autophagy-related long non-coding RNA is a prognostic indicator for bladder cancer","volume":"11","author":"J Wan","year":"2021","journal-title":"Front Oncol"},{"key":"pone.0315927.ref042","doi-asserted-by":"crossref","first-page":"608668","DOI":"10.3389\/fgene.2020.608668","article-title":"Prognosis-predictive signature and nomogram based on autophagy-related long non-coding RNAs for hepatocellular carcinoma","volume":"11","author":"Y Jia","year":"2020","journal-title":"Front Genet"},{"issue":"1","key":"pone.0315927.ref043","doi-asserted-by":"crossref","first-page":"22910","DOI":"10.1038\/s41598-023-50039-x","article-title":"Comprehensive analysis of the potential biological significance of cuproptosis-related gene LIPT2 in pan-cancer prognosis and immunotherapy","volume":"13","author":"W Wang","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0315927.ref044","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00109-013-1105-2","article-title":"Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells","volume":"92","author":"M Mart\u00edn-Rufi\u00e1n","year":"2014","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"pone.0315927.ref045","first-page":"vdaa149","article-title":"The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling","volume":"3","author":"AS Yamashita","year":"2020","journal-title":"Neurooncol Adv"},{"issue":"1","key":"pone.0315927.ref046","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11060-016-2073-5","article-title":"Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids","volume":"128","author":"EH Panosyan","year":"2016","journal-title":"J Neurooncol"},{"issue":"1","key":"pone.0315927.ref047","first-page":"BC25","article-title":"Serum levels of metal ions in female patients with breast cancer","volume":"9","author":"V Pavithra","year":"2015","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"pone.0315927.ref048","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12011-016-0768-2","article-title":"Changes in the serum levels of trace elements before and after the operation in thyroid cancer patients","volume":"175","author":"AK Baltaci","year":"2017","journal-title":"Biol Trace Elem Res"},{"issue":"1\u20133","key":"pone.0315927.ref049","first-page":"41","article-title":"Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia","volume":"114","author":"XL Zuo","year":"2006","journal-title":"Biol Trace Elem Res"},{"issue":"5","key":"pone.0315927.ref050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4103\/2319-4170.132888","article-title":"Serum levels of ferritin, copper, and zinc in patients with oral cancer","volume":"37","author":"M Baharvand","year":"2014","journal-title":"Biomed J"},{"issue":"12","key":"pone.0315927.ref051","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.3390\/cancers12123594","article-title":"The multifaceted roles of copper in cancer: a trace metal element with dysregulated metabolism, but also a target or a bullet for therapy","volume":"12","author":"P Leli\u00e8vre","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"13","key":"pone.0315927.ref052","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.7150\/thno.74281","article-title":"Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma","volume":"12","author":"N Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"7","key":"pone.0315927.ref053","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00262-020-02836-w","article-title":"Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values","volume":"70","author":"AR Kim","year":"2021","journal-title":"Cancer Immunol Immunother"},{"key":"pone.0315927.ref054","doi-asserted-by":"crossref","first-page":"781466","DOI":"10.3389\/fimmu.2021.781466","article-title":"An immunogenic cell death-related classification predicts prognosis and response to immunotherapy in head and neck squamous cell carcinoma","volume":"12","author":"X Wang","year":"2021","journal-title":"Front Immunol"},{"issue":"11","key":"pone.0315927.ref055","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41575-021-00486-6","article-title":"Cell death in pancreatic cancer: from pathogenesis to therapy","volume":"18","author":"X Chen","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"pone.0315927.ref056","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41420-022-01161-8","article-title":"Cell death affecting the progression of gastric cancer","volume":"8","author":"H Wang","year":"2022","journal-title":"Cell Death Discov"},{"issue":"5 Suppl","key":"pone.0315927.ref057","doi-asserted-by":"crossref","first-page":"1064S","DOI":"10.1093\/ajcn\/67.5.1064S","article-title":"Copper and immunity","volume":"67","author":"SS Percival","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"pone.0315927.ref058","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2020.12.003","article-title":"Copper in infectious disease: using both sides of the penny","volume":"115","author":"EM Culbertson","year":"2021","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"pone.0315927.ref059","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1215\/15228517-2008-111","article-title":"Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma","volume":"11","author":"NL Bryant","year":"2009","journal-title":"Neuro Oncol"},{"key":"pone.0315927.ref060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biocel.2014.10.005","article-title":"Glioma cell-derived placental growth factor induces regulatory B cells","volume":"57","author":"S Han","year":"2014","journal-title":"Int J Biochem Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0315927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T14:00:08Z","timestamp":1738850408000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0315927"}},"subtitle":[],"editor":[{"given":"Abeer","family":"El Wakil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0315927","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}