{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T04:09:00Z","timestamp":1754021340668,"version":"3.37.3"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/05650-6"],"award-info":[{"award-number":["2014\/05650-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nIncreased cardiac after load and multiple non-hemodynamic stimuli implicate in adverse left ventricular remodeling (LVR). This is particularly identifiable in treatment-resistant and secondary hypertension contexts, like primary hyperaldosteronism (PA), however little data exists on post-treatment residual LVR in these individuals.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nCardiac magnetic resonance (CMR) with T1 mapping were performed in 14 patients with treated PA matched with 15 treated patients with primary hypertension (PH) and 15 healthy individuals. Blood pressure (BP) control was defined as < 140 x 90mmHg.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nTreated PA and PH patients had similar indexed left ventricular, extracellular matrix and intracellular masses (respectively 68 \u00b1 12g\/m2, 17 \u00b1 3g\/m2 and 52 \u00b1 10g\/m2 for PA vs 63 \u00b1 18g\/m2, 16 \u00b1 5g\/m2 and 47 \u00b1 14g\/m2 for PH, p > 0.05 for all), that were significantly higher than normal individuals (47 \u00b1 8g\/m2, 11 \u00b1 2g\/m2 and 36 \u00b1 6g\/m2, respectively, p < 0.05 for all). Patients with uncontrolled BP exhibited greater cardiomyocyte hypertrophy than those controlled (55 \u00b1 11 g\/m2 vs 43 \u00b1 11 g\/m2, p = 0.01), regardless of the cause of hypertension. PH individuals had strong correlations between BP measurements and LVR parameters of the CMR, while in PA correlations were weaker.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nIn treated patients with PA and PH, CMR detected similar residual tissue LVR in both groups. Uncontrolled BP was more related to the observed LVR than to the etiology of hypertension. BP levels were more strongly correlated to CMR LVR parameters in PH than PA patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0316140","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T18:44:08Z","timestamp":1734979448000},"page":"e0316140","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left ventricle remodeling by CMR in treated patients with primary aldosteronism and primary systemic arterial hypertension"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-7186","authenticated-orcid":true,"given":"Carolina S.","family":"Reiser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonildes N.","family":"Assuncao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A. 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