{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:41:24Z","timestamp":1781707284609,"version":"3.54.5"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec011\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>The aim was to analyze the association of subfoveal choroidal thickness (SFCT) with age, best-corrected visual acuity, refractive error, and axial length in Taiwan pediatric population.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec012\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 374 eyes in 187 children were enrolled in this retrospective cross-sectional comparative study, who underwent examinations of best-corrected visual acuity (BCVA), cycloplegic refraction, and axial length (AL). Subfoveal choroidal thickness was assessed utilizing spectral domain enhanced depth imaging optical coherence tomography (EDI-OCT), with measurements taken at the subfovea, defined as the distance from the retinal pigment epithelium to the chorioscleral border.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec013\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age was 5.6\u2009\u00b1\u20091.9 years (range 2\u201316 years). The cycloplegic spherical equivalent refractive error was between\u2009+\u20097.25 and - 15.25 diopters (D) and cycloplegic sphere power was between\u2009+\u20098.25 and - 11.5 diopters (D). The mean SFCT was 299.0\u2009\u00b1\u200969.80 \u03bcm. The mean axial length was 22.87\u2009\u00b1\u20091.29\u2009mm. In univariate analysis, SFCT had significant positive correlations with spherical equivalent (SE) and sphere power (p\u2009&lt;\u20090.05) and significant negative correlations with age, cylinder power, and axial length (p\u2009&lt;\u20090.05). However, after adjusting in the multivariate regression analysis, spherical equivalent, sphere power and age were not independently associated with SFCT. In multivariate analysis, lower cylinder power and longer axial length have significant correlations with thinner SFCT. The relationship between best-corrected visual acuity and SFCT was not significant in both analyses.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec014\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study showed that mean subfoveal choroidal thickness was 299.0\u2009\u00b1\u200969.80 \u03bcm among Taiwanese children. The SFCT was thinner in myopic, longer axial length, and lower cylinder power eyes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0316306","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T17:54:07Z","timestamp":1747677247000},"page":"e0316306","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["The association between subfoveal choroidal thickness and refractive error in Taiwanese children: A cross-sectional 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