{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:17:06Z","timestamp":1790810226920,"version":"4.1.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Fluctuation-related pain (FRP) affects more than one third of people with Parkinson\u2019s disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excellence (NICE) recommends The Parkinson KinetiGraph<jats:sup>TM<\/jats:sup> (the PKG<jats:sup>TM<\/jats:sup>) for remote monitoring of motor symptoms. We investigated potential links between the PKG<jats:sup>TM<\/jats:sup>-obtained parameters and clinical rating scores for FRP in PwP in an exploratory, cross-sectional analysis of two prospective studies: \u201c<jats:italic>The Non-motor International Longitudinal<\/jats:italic>, <jats:italic>Real-Life Study in PD\u2014NILS<\/jats:italic>\u201d and \u201c<jats:italic>An observational-based registry of baseline PKG\u2122 in PD\u2014PKGReg<\/jats:italic>\u201d. 63 PwP (41.3% female; age: 64.24\u00b19.88 years; disease duration, DD: 6.83\u00b15.63 years; Hoehn and Yahr Stage, H&amp;Y: 2 (1\u20134); Levodopa Equivalent Daily Dose 535 (0\u20133230) mg) were included. PwP with FRP (n = 23) had longer DD (8.88 (1.29\u201319.05) vs. 3.16 (0.34\u201328.92), <jats:italic>p<\/jats:italic> = 0.001), higher severity of motor symptoms (H&amp;Y 3 (1\u20134) vs. 2 (1\u20134), <jats:italic>p<\/jats:italic> = 0.015; SCOPA Motor total score 21.35\u00b110.19 vs. 13.65\u00b18.99, <jats:italic>p<\/jats:italic> = 0.003), more dyskinesia (SCOPA Motor Item 18 \u22651 60.9% vs. 7.5%, <jats:italic>p<\/jats:italic>&lt;0.001), and worse HRQoL (PDQ-8 Total Score 10.74\u00b15.98 vs. 6.78\u00b15.13, <jats:italic>p<\/jats:italic> = 0.007) then PwP without FRP (n = 40). In the multivariate logistic regression, after the adjustment for DD, H&amp;Y and SCOPA-Motor total score, the presence of FRP was significantly associated with the PKG<jats:sup>TM<\/jats:sup>-derived Fluctuation-dyskinesia score (Exp (B) = 1.305, 95% CI for Exp (B) 1.012\u20131.683, <jats:italic>p<\/jats:italic> = 0.040) and the Bradykinesia score (Exp (B) = 0.917, 95% CI for Exp (B) 0.842\u20130.999, <jats:italic>p<\/jats:italic> = 0.048). The PKG<jats:sup>TM<\/jats:sup> system may potentially advance the way we screen for, assess, and treat FRP in clinical practice.<\/jats:p>","DOI":"10.1371\/journal.pone.0316563","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T18:34:16Z","timestamp":1736879656000},"page":"e0316563","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Wearable devices may aid the recognition of fluctuation-related pain in Parkinson\u2019s disease\u2014An exploratory, cross-sectional analysis of two prospective observational studies"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-5058","authenticated-orcid":true,"given":"Katarina","family":"Rukavina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Staunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Zinzalias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Krbot Skoric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Bannister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ray Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"issue":"11","key":"pone.0316563.ref001","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S1473-3099(17)30396-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015","volume":"17","author":"GL Collaborators","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"pone.0316563.ref002","author":"WP epidemiology"},{"issue":"s1","key":"pone.0316563.ref003","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The Emerging Evidence of the Parkinson Pandemic.","volume":"8","author":"ER Dorsey","year":"2018","journal-title":"J Parkinsons Dis"},{"key":"pone.0316563.ref004","unstructured":"Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease."},{"issue":"7","key":"pone.0316563.ref005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease.","volume":"18","author":"AHV Schapira","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"pone.0316563.ref006","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"RB Postuma","year":"2015","journal-title":"Mov Disord"},{"issue":"4","key":"pone.0316563.ref007","first-page":"1817","volume":"10","author":"P Ghosh","year":"2020","journal-title":"A Dual Centre Study of Pain in Parkinson\u2019s Disease and Its Relationship with Other Non-Motor Symptoms. 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