{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:21:14Z","timestamp":1784845274582,"version":"3.55.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec025\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Anxiety is a prevalent psychological issue among cancer patients, significantly affecting their quality of life and potentially influencing treatment outcomes. This study aims to investigate the prevalence and associated factors of anxiety among cancer patients at the University of Gondar Comprehensive Specialized Hospital in Northwest Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec026\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A cross-sectional study design was used, involving 384 cancer patients, selected by systematic random sampling technique, from the oncology ward. Data were collected using the Generalized Anxiety Disorder 7-item (GAD-7) scale and the Oslo Social Support Scale (OSS-3). Descriptive and inferential statistics, including bi-variable and multi-variable logistic regression analyses, were employed to analyze the data.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec027\">\n<jats:title>Results<\/jats:title>\n<jats:p>The prevalence of anxiety was 88.3%, with 34.4% of patients experiencing severe anxiety, 29.2% moderate anxiety, and 24.7% mild anxiety. Significant predictors of anxiety included participants age&gt;= 61years (AOR =\u2009 2.99, 95% CI =\u2009 1.31\u20136.79), participants age 30-60 years (AOR =\u2009 4.13, 95% CI =\u2009 1.53\u201311.07), female sex (AOR =\u2009 2.04, 95% CI =\u2009 1.02\u20134.07), advanced cancer stage (AOR =\u2009 3.08, 95% CI =\u2009 1.11\u20138.53), and ongoing treatment (AOR =\u2009 2.40, 95% CI =\u2009 1.14<jats:bold>\u2013<\/jats:bold>5.10).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec028\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The study found a high prevalence of anxiety among cancer patients, compared to the previous studies, highlighting the need for integrated psycho-oncology services. Specific interventions are necessary for high-risk groups, including older patients, females, and those with advanced-stage cancer.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0316748","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:33:03Z","timestamp":1738175583000},"page":"e0316748","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anxiety among cancer patients: A cross-sectional study at The University of Gondar comprehensive specialized hospital"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-2952","authenticated-orcid":true,"given":"Hailu","family":"Aragie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagnew Getnet","family":"Adugna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nega Dagnew","family":"Baye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-4940","authenticated-orcid":true,"given":"Habtu Kifle","family":"Negash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"issue":"6","key":"pone.0316748.ref001","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"pone.0316748.ref002","article-title":"The prevalence of cancer and its associated risk factors among patients visiting oncology unit, Tikur Anbessa Specialized Hospital, Addis Ababa-Ethiopia.","volume":"9","author":"M Woldu","year":"2017","journal-title":"J Cancer Sci Ther"},{"issue":"2","key":"pone.0316748.ref003","first-page":"90","article-title":"Prevalence of depression in cancer patients: a review on the comparison between different regions","volume":"23","author":"C Ng","year":"2014","journal-title":"Malay J Psychiatry"},{"issue":"12","key":"pone.0316748.ref004","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1249\/MSS.0000000000000360","article-title":"Cancer-related impairments influence physical activity in uterine cancer survivors","volume":"46","author":"SM Hammer","year":"2014","journal-title":"Med Sci Sports Exerc"},{"issue":"14","key":"pone.0316748.ref005","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1200\/JCO.2002.08.549","article-title":"Anxiety disorders in cancer patients: their nature, associations, and relation to quality of life","volume":"20","author":"D Stark","year":"2002","journal-title":"J Clin Oncol"},{"issue":"11","key":"pone.0316748.ref006","doi-asserted-by":"crossref","first-page":"e007618","DOI":"10.1136\/bmjopen-2015-007618","article-title":"Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates","volume":"5","author":"S Watts","year":"2015","journal-title":"BMJ Open"},{"issue":"5","key":"pone.0316748.ref007","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/annonc\/mdp515","article-title":"Prevalence of mental health conditions in cancer patients in acute care--a meta-analysis","volume":"21","author":"S Singer","year":"2010","journal-title":"Ann Oncol"},{"issue":"2","key":"pone.0316748.ref008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/0253-7176.101774","article-title":"The effect of anxiety on breast cancer patients","volume":"34","author":"SMS Baqutayan","year":"2012","journal-title":"Indian J Psychol Med"},{"issue":"1","key":"pone.0316748.ref009","doi-asserted-by":"crossref","first-page":"1073274819864641","DOI":"10.1177\/1073274819864641","article-title":"Anxiety among inpatients with cancer: findings from a Hospital-based cross-sectional study in Vietnam","volume":"26","author":"DV Truong","year":"2019","journal-title":"Cancer Control"},{"issue":"5","key":"pone.0316748.ref010","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/13548506.2015.1125006","article-title":"Depression and anxiety symptoms following cancer diagnosis: a cross-sectional study","volume":"21","author":"G Cardoso","year":"2016","journal-title":"Psychol Health Med"},{"issue":"2","key":"pone.0316748.ref011","doi-asserted-by":"crossref","first-page":"42","DOI":"10.17352\/2455-5460.000022","article-title":"Prevalence and correlates of anxiety and depression among cancer patients in the University of Gondar comprehensive specialized hospital, Northwest Ethiopia","volume":"3","author":"F Berihun","year":"2017","journal-title":"Archiv Depress Anxiety"},{"issue":"10","key":"pone.0316748.ref012","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"RL Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"6","key":"pone.0316748.ref013","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00127-006-0051-5","article-title":"Negative life events, social support and gender difference in depression: a multinational community survey with data from the ODIN study","volume":"41","author":"OS Dalgard","year":"2006","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"3","key":"pone.0316748.ref014","first-page":"167","article-title":"Prevalence of depression and anxiety among cancer patients","volume":"5","author":"N Nikbakhsh","year":"2014","journal-title":"Caspian J Intern Med"},{"issue":"1","key":"pone.0316748.ref015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12885-017-3347-9","article-title":"Anxiety and depression in working-age cancer survivors: a register-based study","volume":"17","author":"L Inhestern","year":"2017","journal-title":"BMC Cancer"},{"issue":"6","key":"pone.0316748.ref016","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jpsychores.2012.08.010","article-title":"Body image as a predictor of psychopathology in surgical patients with colorectal disease","volume":"73","author":"TL Bullen","year":"2012","journal-title":"J Psychosom Res"},{"issue":"4","key":"pone.0316748.ref017","doi-asserted-by":"crossref","first-page":"158","DOI":"10.48029\/NJI.2015.CVI406","article-title":"Anxiety among cancer patients at selected hospital of Haryana","volume":"106","author":"P Ahlawat","year":"2015","journal-title":"Nurs J India"},{"issue":"2","key":"pone.0316748.ref018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1213\/00000539-199108000-00013","article-title":"A survey of 800 patients\u2019 knowledge, attitudes, and concerns regarding anesthesia","volume":"73","author":"K Shevde","year":"1991","journal-title":"Anesth Analg"},{"issue":"1","key":"pone.0316748.ref019","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00540-012-1460-0","article-title":"Patient\u2019s anxiety and fear of anesthesia: effect of gender, age, education, and previous experience of anesthesia. A survey of 400 patients","volume":"27","author":"P Mavridou","year":"2013","journal-title":"J Anesthesia"},{"issue":"1","key":"pone.0316748.ref020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40001-018-0339-4","article-title":"Evaluation of preoperative anxiety and fear of anesthesia using APAIS score","volume":"23","author":"F Celik","year":"2018","journal-title":"Eur J Med Res"},{"issue":"4","key":"pone.0316748.ref021","first-page":"243","article-title":"Validation of the Malay version of the Amsterdam Preoperative Anxiety and Information Scale (APAIS)","volume":"70","author":"Z Mohd Fahmi","year":"2015","journal-title":"Med J Malay"},{"key":"pone.0316748.ref022","first-page":"9","article-title":"Gender differences in the presentation and management of social anxiety disorder","author":"LS Weinstock","year":"1999","journal-title":"J Clin Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0316748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:33:16Z","timestamp":1738175596000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0316748"}},"subtitle":[],"editor":[{"given":"Zelalem Belayneh","family":"Muluneh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0316748","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}