{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:43:22Z","timestamp":1775594602250,"version":"3.50.1"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["RED-00570-16, RED-00213-23),"],"award-info":[{"award-number":["RED-00570-16, RED-00213-23),"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The short-chain fatty acid (SCFA) propionate, beyond its actions on the intestine, has been able to lower inflammation and modulate angiogenesis and fibrogenesis in pathological conditions in experimental animal models. Its effects on foreign body reaction (FBR), an abnormal healing process induced by implantation of medical devices, have not been investigated. We have evaluated the effects of sodium propionate (SP) on inflammation, neovascularization and remodeling on a murine model of implant-induced FBR. Polyether-polyurethane sponge discs implanted subcutaneously in C57BL\/6 mice provided the scaffold for the formation of the fibrovascular tissue. Fifteen-day old implants of the treated group (SP, 100 mg\/kg for 14 days) presented a decrease in the inflammatory response as evaluated by cellular influx (flow cytometry; Neutrophils 54%; Lymphocytes 25%, Macrophages 40%). Myeloperoxidase activity, TNF-\u03b1 levels and mast cell number were also lower in the treated group relative to the control group. Angiogenesis was evaluated by blood vessel number and VEGF levels, which were downregulated by the treatment. Moreover, the number of foreign body giant cells HE (FBGC) and the thickness of the collagenous capsule were reduced by 58% and 34%, respectively. Collagen deposition inside the implant, TGF-\u03b21 levels, \u03b1-SMA and TGF-\u03b21 expression were also reduced. These effects may indicate that SP holds potential as a therapeutic agent for attenuating adverse remodeling processes associated with implantable devices, expanding its applications in biomedical contexts.<\/jats:p>","DOI":"10.1371\/journal.pone.0316764","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T18:26:02Z","timestamp":1739989562000},"page":"e0316764","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sodium propionate decreases implant-induced foreign body response in mice"],"prefix":"10.1371","volume":"20","author":[{"given":"Deivenita Juliana Alves Carvalho","family":"do Carmo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Guimar\u00e3es Takahashi","family":"Lazari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Cristine 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Kyriakides","year":"2022","journal-title":"Biomed Mater"},{"issue":"5","key":"pone.0316764.ref038","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.actbio.2013.12.056","article-title":"Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kit(w-Sh) murine model","volume":"10","author":"MN Avula","year":"2014","journal-title":"Acta Biomater"},{"issue":"4","key":"pone.0316764.ref039","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"O Soehnlein","year":"2017","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"pone.0316764.ref040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/rb\/rbw041","article-title":"An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration","volume":"4","author":"GS Selders","year":"2017","journal-title":"Regen 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Carmeliet","year":"2004","journal-title":"J Intern Med"},{"issue":"1","key":"pone.0316764.ref066","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI88883","article-title":"The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis","volume":"127","author":"C Crewe","year":"2017","journal-title":"J Clin Invest"},{"key":"pone.0316764.ref067","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2015.01.038","article-title":"Prevention of foreign body reaction in a pre-clinical large animal model","volume":"202","author":"M Kastellorizios","year":"2015","journal-title":"J Control Release"},{"issue":"4935","key":"pone.0316764.ref068","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.2479987","article-title":"Vascular permeability factor, an endothelial cell mitogen related to PDGF","volume":"246","author":"PJ Keck","year":"1989","journal-title":"Science"},{"issue":"2","key":"pone.0316764.ref069","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02478931","article-title":"Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells","volume":"19","author":"H Sawa","year":"2002","journal-title":"Brain Tumor Pathol"},{"issue":"4","key":"pone.0316764.ref070","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.07.172","article-title":"Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF","volume":"335","author":"M Belakavadi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0316764.ref071","doi-asserted-by":"crossref","first-page":"34649","DOI":"10.1038\/srep34649","article-title":"Low Concentration of Sodium Butyrate from Ultrabraid+NaBu suture, Promotes Angiogenesis and Tissue Remodelling in Tendon-bones Injury","volume":"6","author":"D Liu","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0316764.ref072","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","article-title":"Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model","volume":"30","author":"G Chen","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"pone.0316764.ref073","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1021\/bm5017282","article-title":"Long-term sustained release of salicylic acid from cross-linked biodegradable polyester induces a reduced foreign body response in mice","volume":"16","author":"Y Chandorkar","year":"2015","journal-title":"Biomacromolecules"},{"issue":"15","key":"pone.0316764.ref074","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S1286-4579(99)00250-6","article-title":"TGF-beta and fibrosis","volume":"1","author":"MH Branton","year":"1999","journal-title":"Microbes Infect"},{"issue":"3","key":"pone.0316764.ref075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1096\/fj.03-0699com","article-title":"Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation","volume":"18","author":"GR Grotendorst","year":"2004","journal-title":"FASEB J"},{"key":"pone.0316764.ref076","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.14.2.163","article-title":"Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis","volume":"14","author":"Q Yo","year":"2000","journal-title":"Genes Dev"},{"key":"pone.0316764.ref077","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodeling","volume":"8","author":"A Page-McCaw","year":"2007","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0316764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T18:26:28Z","timestamp":1739989588000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0316764"}},"subtitle":[],"editor":[{"given":"Wei-Chun","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":77,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0316764","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]}}}