{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:02:14Z","timestamp":1778036534058,"version":"3.51.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec019\">\n<jats:title>Background<\/jats:title>\n<jats:p>End-stage renal disease (ESRD) patients frequently experience protein-energy wasting (PEW), which increases their morbidity and mortality rates.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec020\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study explores the effects of nutritional status and pulmonary function on the short- and long-term mortality of ESRD patients undergoing hemodialysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec021\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>67 consecutive ESRD patients on maintenance hemodialysis were included in the study. The primary outcomes were all-cause one-year and five-year mortality. Data on demographic characteristics, comorbidities, and laboratory findings were collected. Pulmonary function tests were conducted along with body composition measurements using bioelectrical impedance analysis (BIA). Malnutrition was assessed using the Prognostic Nutritional Index (PNI).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec022\">\n<jats:title>Results<\/jats:title>\n<jats:p>The median age of the patients was 60.9 \u00b1\u2009 12.4 years, with 58.3% being male. Pulmonary function parameters (FEV1 and FVC) were significantly associated with short-term mortality. The PNI was a significant predictor of both short-term and long-term mortality. A PNI score \u2264\u2009 39.01 was associated with increased short-term mortality (HR: 0.65, 95% CI: 0.48\u20130.88, p =\u2009 0.006), while a score \u2264\u2009 40 was linked to increased long-term mortality (HR: 0.80, 95% CI: 0.67\u20130.95, p =\u2009 0.015). Additionally, older age (HR: 1.06, 95% CI: 1.01\u20131.12, p =\u2009 0.021) and higher glomerular filtration rate (GFR) (HR: 1.23, 95% CI: 1.02\u20131.42, p =\u2009 0.024) were related to increased long-term mortality risk.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec023\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The study demonstrates that PNI, age, and pulmonary function are critical factors influencing the survival of hemodialysis patients. These findings underscore the importance of comprehensive nutritional and pulmonary assessment to improve clinical outcomes in this population.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0317510","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T18:41:15Z","timestamp":1738003275000},"page":"e0317510","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of nutritional status and pulmonary function on short- and long-term overall survival in hemodialysis patients"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-3205","authenticated-orcid":true,"given":"\u00d6zge","family":"Ayd\u0131n G\u00fc\u00e7l\u00fc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasim Atakan","family":"Erol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil\u00fcfer Aylin","family":"Acet \u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Gorek\u00a0Dilektasli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmecid","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karadag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"3","key":"pone.0317510.ref001","doi-asserted-by":"crossref","first-page":"c269-77","DOI":"10.1159\/000321382","article-title":"The burden of chronic kidney disease on developing nations: a 21st century challenge in global health","volume":"118","author":"RA Nugent","year":"2011","journal-title":"Nephron Clin Pract"},{"issue":"3","key":"pone.0317510.ref002","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.clnu.2016.06.007","article-title":"Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis","volume":"36","author":"A Sabatino","year":"2017","journal-title":"Clin Nutr"},{"key":"pone.0317510.ref003","volume-title":"Why is protein\u2013energy wasting associated with mortality in chronic kidney disease? 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