{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T20:07:10Z","timestamp":1783282030869,"version":"3.54.6"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82173638"],"award-info":[{"award-number":["NSFC 82173638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["YQ2022H005"],"award-info":[{"award-number":["YQ2022H005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is an inflammatory skin disease, and current treatments have their own limitations, including moderate treatment effectiveness, poor compliance, and potential safety risks, etc. Therefore, the primary focus of this study is to explore novel molecular targets and improve the diagnosis and treatment of psoriasis patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method<\/jats:title>\n<jats:p>In this study, comprehensive bioinformatics analysis was performed on the expression profiles of tissue samples from patients with psoriasis in the clinical trial of TYK2\/JAK1 inhibitor treatment (NCT02310750). Weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression were performed to identify characteristic genes and construct the diagnostic models. Gene set enrichment analysis (GSEA) was used to identify the biological processes of psoriasis characteristic gene sets. GO and KEGG pathway analysis were combined to elucidate the potential biological significance of differentially expressed genes (DEGs). The accuracy of biomarker identification was further validated using immune cell infiltration and receiver operating characteristic (ROC) curves based on external data (GSE6710\\GSE30999\\GSE14905).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 5 genes (<jats:italic>DEFB103A, OAS3, OASL, SAMD9, STAT1<\/jats:italic>) were co-identified as characteristic genes in psoriasis progression and treatment. The feature of the immune cell infiltration was highly consistent with association of characteristic biomarkers with immune cells. A total of 14 up-regulated genes and 5 down-regulated genes were identified in respective modules (AUC <jats:sub>NL\/LS<\/jats:sub>\u2009=\u20090.9783; AUC <jats:sub>pre\/post<\/jats:sub>\u2009=\u20090.9395; AUC <jats:sub>external<\/jats:sub>\u2009=\u20090.9469). In addition, 8 genes (<jats:italic>DEFB103A, OASL, HERC6, ISG15, MKI67, MX1, MXD1, SCO2<\/jats:italic>) were considered to have statistically significant differences in sensitivity of short-term treatment for psoriasis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The research findings provide an understanding of the role of novel biomarkers and offer a perspective for further in-depth investigation into the progression and treatment of psoriasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0317666","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:48:21Z","timestamp":1750873701000},"page":"e0317666","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of novel biomarkers related to pathogenesis and treatment of psoriasis based on integrated analysis of weighted gene co-expression network analysis and LASSO"],"prefix":"10.1371","volume":"20","author":[{"given":"Chenguang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-7258","authenticated-orcid":true,"given":"Lijun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"issue":"10281","key":"pone.0317666.ref001","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"CEM Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"3","key":"pone.0317666.ref002","doi-asserted-by":"crossref","DOI":"10.1016\/S2665-9913(20)30397-0","article-title":"Safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of the oral TYK2 inhibitor PF-06826647 in participants with plaque psoriasis: a phase 1, randomised, double-blind, placebo-controlled, parallel-group study","volume":"3","author":"C Tehlirian","year":"2021","journal-title":"Lancet Rheumatol"},{"issue":"6","key":"pone.0317666.ref003","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.jaci.2018.11.038","article-title":"HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis","volume":"143","author":"N Dand","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"pone.0317666.ref004","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaad.2017.05.019","article-title":"Psoriasis and suicidality: A systematic review and meta-analysis","volume":"77","author":"S Singh","year":"2017","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"pone.0317666.ref005","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2133.2009.09030.x","article-title":"Plaque thickness and morphology in psoriasis vulgaris associated with therapeutic response","volume":"160","author":"T Rakkhit","year":"2009","journal-title":"Br J Dermatol"},{"issue":"9583","key":"pone.0317666.ref006","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"CE Griffiths","year":"2007","journal-title":"Lancet"},{"key":"pone.0317666.ref007","first-page":"93","article-title":"Erythrodermic psoriasis: pathophysiology and current treatment perspectives","volume":"6","author":"RK Singh","year":"2016","journal-title":"Psoriasis (Auckl)"},{"issue":"10","key":"pone.0317666.ref008","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/jdv.14949","article-title":"Generalized pustular psoriasis: a review and update on treatment","volume":"32","author":"KM Hoegler","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"pone.0317666.ref009","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/jid.2009.319","article-title":"Molecular dissection of psoriasis: integrating genetics and biology","volume":"130","author":"JT Elder","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"3","key":"pone.0317666.ref010","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3384","article-title":"Psoriasis and Genetics","volume":"100","author":"N Dand","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"pone.0317666.ref011","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study","volume":"369","author":"R Parisi","year":"2020","journal-title":"BMJ"},{"issue":"3","key":"pone.0317666.ref012","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/1744666X.2022.1993061","article-title":"Evaluating topical JAK inhibitors as a treatment option for atopic dermatitis","volume":"18","author":"MI Fardos","year":"2022","journal-title":"Expert Rev Clin Immunol"},{"issue":"3","key":"pone.0317666.ref013","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7861\/clinmed.2021-0257","article-title":"Psoriasis: a brief overview","volume":"21","author":"A Raharja","year":"2021","journal-title":"Clin Med (Lond)"},{"key":"pone.0317666.ref014","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3389\/fimmu.2019.01862","article-title":"Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases","volume":"10","author":"KP Szilveszter","year":"2019","journal-title":"Front Immunol"},{"issue":"4","key":"pone.0317666.ref015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s40265-020-01261-8","article-title":"JAK Inhibitors for Treatment of Psoriasis: Focus on Selective TYK2 Inhibitors","volume":"80","author":"M Nogueira","year":"2020","journal-title":"Drugs"},{"issue":"13","key":"pone.0317666.ref016","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2217\/imt-2021-0096","article-title":"TYK2 as a therapeutic target in the treatment of autoimmune and inflammatory diseases","volume":"13","author":"M Gonciarz","year":"2021","journal-title":"Immunotherapy"},{"issue":"4","key":"pone.0317666.ref017","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jaad.2008.12.032","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies","volume":"60","author":"A Menter","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"pone.0317666.ref018","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jaad.2019.04.042","article-title":"Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy","volume":"81","author":"CA Elmets","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"pone.0317666.ref019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jaad.2018.06.057","article-title":"Psoriasis: Which therapy for which patient: Psoriasis comorbidities and preferred systemic agents","volume":"80","author":"SB Kaushik","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"pone.0317666.ref020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/17474124.2019.1579641","article-title":"Non-invasive assessment of liver fibrosis and prognosis: an update on serum and elastography markers","volume":"13","author":"U Agbim","year":"2019","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"5","key":"pone.0317666.ref021","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM199101313240501","article-title":"Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial","volume":"324","author":"CN Ellis","year":"1991","journal-title":"N Engl J Med"},{"issue":"6","key":"pone.0317666.ref022","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/exd.13548","article-title":"A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis","volume":"27","author":"J Br\u00fcck","year":"2018","journal-title":"Exp Dermatol"},{"issue":"2","key":"pone.0317666.ref023","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/09546630802441234","article-title":"Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases","volume":"20","author":"JM Ko","year":"2009","journal-title":"J Dermatolog Treat"},{"issue":"6","key":"pone.0317666.ref024","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/14712598.2020.1727439","article-title":"Clinical and histopathological characterization of eczematous eruptions occurring in course of anti IL-17 treatment: a case series and review of the literature","volume":"20","author":"G Caldarola","year":"2020","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"pone.0317666.ref025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/bjd.12039","article-title":"Adherence to medication in patients with psoriasis: a systematic literature review","volume":"168","author":"RJ Thorneloe","year":"2013","journal-title":"Br J Dermatol"},{"issue":"6","key":"pone.0317666.ref026","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1001\/jamadermatol.2014.5479","article-title":"Developing a Therapeutic Range of Adalimumab Serum Concentrations in Management of Psoriasis: A Step Toward Personalized Treatment","volume":"151","author":"SP Menting","year":"2015","journal-title":"JAMA Dermatol"},{"issue":"1","key":"pone.0317666.ref027","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jid.2018.07.028","article-title":"Defining the therapeutic range for adalimumab and predicting response in psoriasis: A multicenter prospective observational cohort study","volume":"139","author":"N Wilkinson","year":"2019","journal-title":"J Invest Dermatol"},{"key":"pone.0317666.ref028","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"P Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"8","key":"pone.0317666.ref029","article-title":"Molecular and Cellular Responses to the TYK2\/JAK1 Inhibitor PF-06700841 Reveal Reduction of Skin Inflammation in Plaque Psoriasis","volume":"140","author":"KM Page","year":"2020","journal-title":"J Invest Dermatol"},{"issue":"43","key":"pone.0317666.ref030","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0317666.ref031","article-title":"Gene Ontology Consortium: going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"pone.0317666.ref032","article-title":"The Gene Ontology Resource: 20 years and still GOing strong","volume":"47","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"pone.0317666.ref033","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"M Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pone.0317666.ref034","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"1","key":"pone.0317666.ref035","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1038\/s41598-022-15609-5","article-title":"Applying logistic LASSO regression for the diagnosis of atypical Crohn\u2019s disease","volume":"12","author":"Y Li","year":"2022","journal-title":"Sci Rep"},{"key":"pone.0317666.ref036","doi-asserted-by":"crossref","first-page":"571165","DOI":"10.3389\/fbioe.2020.571165","article-title":"Lasso Peptides: Heterologous Production and Potential Medical Application","volume":"8","author":"C Cheng","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"pone.0317666.ref037","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3348\/kjr.2004.5.1.11","article-title":"Receiver operating characteristic (ROC) curve: practical review for radiologists","volume":"5","author":"SH Park","year":"2004","journal-title":"Korean J Radiol"},{"key":"pone.0317666.ref038","doi-asserted-by":"crossref","first-page":"712781","DOI":"10.3389\/fimmu.2021.712781","article-title":"The Antimicrobial Peptide Human \u03b2-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR\/JAK2\/STAT3 Signaling Pathway","volume":"12","author":"M Takahashi","year":"2021","journal-title":"Front Immunol"},{"issue":"9","key":"pone.0317666.ref039","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.4049\/jimmunol.1401319","article-title":"Human \u03b2 Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7","volume":"195","author":"AB Lioi","year":"2015","journal-title":"J Immunol"},{"issue":"1","key":"pone.0317666.ref040","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2133.2010.09781.x","article-title":"Expression of antimicrobial peptides in cutaneous infections after skin surgery","volume":"163","author":"MR Kesting","year":"2010","journal-title":"Br J Dermatol"},{"issue":"1","key":"pone.0317666.ref041","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1684\/ejd.2015.2698","article-title":"Enhancement of mRNA expression of survivin and human beta-defensin-3 in lesions of psoriasis vulgaris","volume":"26","author":"F Wang","year":"2016","journal-title":"Eur J Dermatol"},{"issue":"1","key":"pone.0317666.ref042","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/cei.13376","article-title":"Serum IFI16 and anti-IFI16 antibodies in psoriatic arthritis","volume":"199","author":"M De Andrea","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"pone.0317666.ref043","doi-asserted-by":"crossref","first-page":"25381","DOI":"10.1038\/srep25381","article-title":"Up-regulation of interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes","volume":"6","author":"T Cao","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0317666.ref044","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.molimm.2019.12.004","article-title":"2\u2019-5\u2019-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion","volume":"118","author":"G Leisching","year":"2020","journal-title":"Mol Immunol"},{"key":"pone.0317666.ref045","doi-asserted-by":"crossref","first-page":"101329","DOI":"10.1016\/j.coviro.2023.101329","article-title":"The two faces of oligoadenylate synthetase-like: effective antiviral protein and negative regulator of innate immunity","volume":"60","author":"V Rex","year":"2023","journal-title":"Curr Opin Virol"},{"issue":"10","key":"pone.0317666.ref046","article-title":"OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1\u2012Induced Jak1\u2012Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis","volume":"142","author":"Y-Z Huang","year":"2022","journal-title":"J Invest Dermatol"},{"issue":"6","key":"pone.0317666.ref047","article-title":"Discovering novel hub genes and pathways associated with the pathogenesis of psoriasis","volume":"33","author":"L-J Gao","year":"2020","journal-title":"Dermatol Ther"},{"issue":"2","key":"pone.0317666.ref048","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/bjd.12049","volume":"168","author":"A Hald","year":"2013","journal-title":"Br J Dermatol"},{"issue":"2","key":"pone.0317666.ref049","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbrc.2018.05.042","article-title":"STAT1 activation represses IL-22 gene expression and psoriasis pathogenesis","volume":"501","author":"L Bai","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"pone.0317666.ref050","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13029","article-title":"The influence of ustekinumab on expression of STAT1, STAT3, STAT4, SOCS2, and IL17 in patients with psoriasis and in a control","volume":"32","author":"B Grabarek","year":"2019","journal-title":"Dermatol Ther"},{"issue":"3","key":"pone.0317666.ref051","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/ije\/dyaa027","article-title":"Human papillomavirus infection associated with increased risk of new-onset psoriasis: a nationwide population-based cohort study","volume":"49","author":"M-L Chen","year":"2020","journal-title":"Int J Epidemiol"},{"issue":"1","key":"pone.0317666.ref052","doi-asserted-by":"crossref","first-page":"129769","DOI":"10.1016\/j.bbagen.2020.129769","article-title":"Regulation of ABCG4 transporter expression by sterols and LXR ligands","volume":"1865","author":"A Yang","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"1","key":"pone.0317666.ref053","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12920-020-0700-7","article-title":"Transcriptome analysis of HPV-induced warts and healthy skin in humans","volume":"13","author":"LN Al-Eitan","year":"2020","journal-title":"BMC Med Genomics"},{"issue":"4","key":"pone.0317666.ref054","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2340\/00015555-2596","article-title":"Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis","volume":"97","author":"A-K Ekman","year":"2017","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"pone.0317666.ref055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12860-021-00395-1","article-title":"Extracellular matrix alterations in the skin of patients affected by psoriasis","volume":"22","author":"MFMG Wagner","year":"2021","journal-title":"BMC Mol Cell Biol"},{"key":"pone.0317666.ref056","article-title":"Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis","volume":"9","author":"F Fan","year":"2021","journal-title":"PeerJ"},{"issue":"5","key":"pone.0317666.ref057","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s11033-021-06461-3","article-title":"Serum fatty acid binding protein 5 (FABP5) as a potential biomarker of inflammation in psoriasis","volume":"48","author":"D Koz\u0142owska","year":"2021","journal-title":"Mol Biol Rep"},{"issue":"9","key":"pone.0317666.ref058","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12090833","article-title":"Fatty Acid-Binding Proteins in Psoriasis-A Review","volume":"12","author":"J Nowowiejska","year":"2022","journal-title":"Metabolites"},{"key":"pone.0317666.ref059","doi-asserted-by":"crossref","first-page":"106318","DOI":"10.1016\/j.phrs.2022.106318","article-title":"Topical VX-509 attenuates psoriatic inflammation through the STAT3\/FABP5 pathway in keratinocytes","volume":"182","author":"B Yan","year":"2022","journal-title":"Pharmacol Res"},{"issue":"6","key":"pone.0317666.ref060","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.jaci.2015.09.055","article-title":"The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases","volume":"137","author":"JL Harden","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"pone.0317666.ref061","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdermsci.2015.08.004","article-title":"Genomic imprinting in psoriasis and atopic dermatitis: A review","volume":"80","author":"CM Nguyen","year":"2015","journal-title":"J Dermatol Sci"},{"issue":"1","key":"pone.0317666.ref062","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jcp.30587","article-title":"Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect","volume":"237","author":"M Wang","year":"2022","journal-title":"J Cell Physiol"},{"issue":"11","key":"pone.0317666.ref063","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1084\/jem.20160258","article-title":"Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a","volume":"213","author":"KL Cheung","year":"2016","journal-title":"J Exp Med"},{"issue":"15","key":"pone.0317666.ref064","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1016\/j.bmc.2010.06.059","article-title":"Substrate specificity and inhibitory study of human airway trypsin-like protease","volume":"18","author":"M Wysocka","year":"2010","journal-title":"Bioorg Med Chem"},{"issue":"4","key":"pone.0317666.ref065","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.0022-202X.2004.22415.x","article-title":"Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris","volume":"122","author":"K Iwakiri","year":"2004","journal-title":"J Invest Dermatol"},{"issue":"1","key":"pone.0317666.ref066","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3892\/ijmm.2020.4771","article-title":"Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris","volume":"47","author":"S Choudhary","year":"2021","journal-title":"Int J Mol Med"},{"issue":"8","key":"pone.0317666.ref067","doi-asserted-by":"crossref","first-page":"3000605221117138","DOI":"10.1177\/03000605221117138","article-title":"CCNB1 and CCNB2 involvement in the pathogenesis of psoriasis: a bioinformatics study","volume":"50","author":"A-H Li","year":"2022","journal-title":"J Int Med Res"},{"issue":"11","key":"pone.0317666.ref068","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1111\/exd.14927","article-title":"Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1\u03b1 signalling pathway","volume":"32","author":"X Sun","year":"2023","journal-title":"Exp Dermatol"},{"issue":"10","key":"pone.0317666.ref069","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/jdv.13091","article-title":"Antiviral gene expression in psoriasis","volume":"29","author":"RA Raposo","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"pone.0317666.ref070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s41065-020-00141-1","article-title":"Identification of candidate biomarkers and pathways associated with psoriasis using bioinformatics analysis","volume":"157","author":"Y Luo","year":"2020","journal-title":"Hereditas"},{"issue":"11","key":"pone.0317666.ref071","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2019.03.1157","article-title":"Genetic Study on Small Insertions and Deletions in Psoriasis Reveals a Role in Complex Human Diseases","volume":"139","author":"Q Zhen","year":"2019","journal-title":"J Invest Dermatol"},{"issue":"4","key":"pone.0317666.ref072","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116550119","article-title":"Structure and function of an effector domain in antiviral factors and tumor suppressors SAMD9 and SAMD9L","volume":"119","author":"S Peng","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"pone.0317666.ref073","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00424-020-02412-2","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"J Chen","year":"2020","journal-title":"Pflugers Arch"},{"issue":"5","key":"pone.0317666.ref074","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/JLB.4MA0620-703RR","article-title":"MXD1 regulates the H9N2 and H1N1 influenza A virus-induced chemokine expression and their replications in human macrophage","volume":"108","author":"HCH Yim","year":"2020","journal-title":"J Leukoc Biol"},{"key":"pone.0317666.ref075","doi-asserted-by":"crossref","first-page":"15330338211052142","DOI":"10.1177\/15330338211052142","article-title":"MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma","volume":"20","author":"F Du","year":"2021","journal-title":"Technol Cancer Res Treat"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:48:39Z","timestamp":1750873719000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317666"}},"subtitle":[],"editor":[{"given":"Seth Agyei","family":"Domfeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":75,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0317666","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]}}}