{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:19:41Z","timestamp":1785766781553,"version":"3.56.0"},"reference-count":14,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for Higher Education Improvement \u2013 Brazil","award":["Financing Code 001"],"award-info":[{"award-number":["Financing Code 001"]}]},{"name":"National Council for Scientific and Technological Development (CNPq) of the Ministry of Science, Technology and Innovation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100016182","name":"Federal University of Mato Grosso do Sul","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100016182","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec014\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Diseases affecting the cornea are a group of pathological conditions responsible for the main causes of blindness worldwide. Corneal transplantation aims to replace dysfunctional corneal tissue with a transparent tissue graft obtained from a deceased donor, which enables the full recovery of lost vision. Processes are initially performed to prepare the corneal tissue for transplantation in order for this transplant to be viable. There is a gap in knowledge regarding the costs of these processes. This review aims to carry out a robust, broad and current mapping of studies which analyze the costs of processing corneal tissue for transplantation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec015\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The objective of this study is to map the evidence produced in the literature on cost analysis studies of corneal tissue processing.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec016\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>A scoping review will be conducted to map the topic, gather different research designs and identify the available scientific evidence on corneal tissue processing. To this end, a scoping review protocol was developed, registered in the Open Science Framework (accessed at: DOI 10.17605\/OSF.IO\/2X89U), following the good practices described by the Joanna Briggs Institute. The review report will be guided by the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist. The data will be presented descriptively, with a summary of the studies found. The guiding research question of the study is: What is the scope of scientific evidence on the cost analysis of corneal tissue processing for transplants?<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0317681","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T18:35:37Z","timestamp":1739212537000},"page":"e0317681","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost analysis of corneal tissue processing: A scoping review protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1809-9299","authenticated-orcid":true,"given":"Gustavo Moura","family":"Maidana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio","family":"Ferreira J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Machado","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Insabralde de Queiroz","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Dias","family":"Abes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Lima","family":"Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"pone.0317681.ref001","first-page":"160","volume-title":"World report on vision [Internet]","author":"World Health Organization","year":"2019"},{"issue":"9","key":"pone.0317681.ref002","first-page":"e29160","article-title":"A review of corneal transplantation: an insight on the overall global post-COVID-19 impact","volume":"14","author":"J Thakkar","year":"2022","journal-title":"Cureus"},{"issue":"6","key":"pone.0317681.ref003","doi-asserted-by":"crossref","first-page":"31751","DOI":"10.34119\/bjhrv6n6-399","article-title":"Sobreviv\u00eancia do enxerto e resultado visual em pacientes com Ceratocone submetidos a transplante penetrante de c\u00f3rnea","volume":"6","author":"LPM Teles","year":"2023","journal-title":"Braz J Hea Rev"},{"issue":"4","key":"pone.0317681.ref004","doi-asserted-by":"crossref","first-page":"e0249927","DOI":"10.1371\/journal.pone.0249927","article-title":"Cornea donation process and tissue quality for transplantation","volume":"16","author":"GK Pereira Cruz","year":"2021","journal-title":"PLoS One"},{"issue":"4","key":"pone.0317681.ref005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2021.09.010","article-title":"The economic burden of vision loss and blindness in the United States","volume":"129","author":"DB Rein","year":"2022","journal-title":"Ophthalmology"},{"issue":"2","key":"pone.0317681.ref006","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global survey of corneal transplantation and eye banking","volume":"134","author":"P Gain","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"pone.0317681.ref007","doi-asserted-by":"crossref","first-page":"100724","DOI":"10.1016\/j.trre.2022.100724","article-title":"Costs related to obtaining organs for transplantation: a systematic review","volume":"36","author":"Silva AMD","year":"2022","journal-title":"Trans Rev (Orlando)"},{"key":"pone.0317681.ref008","first-page":"37","article-title":"Revis\u00e3o de escopo: potencialidades para a s\u00edntese de metodologias utilizadas em pesquisa prim\u00e1ria qualitativa.","author":"L Cordeiro","year":"2019"},{"issue":"3","key":"pone.0317681.ref009","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1590\/S0001-37652009000300017","article-title":"Visual impairment and blindness: an overview of prevalence and causes in Brazil","volume":"81","author":"SR Salom\u00e3o","year":"2009","journal-title":"Anais Acad Bras Ci\u00eancias"},{"key":"pone.0317681.ref010","volume-title":"JBI Manual for Evidence Synthesis","author":"MD Peters","year":"2020"},{"key":"pone.0317681.ref011","author":"Joanna Briggs Institute","year":"2015"},{"issue":"7","key":"pone.0317681.ref012","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"AC Tricco","year":"2018","journal-title":"Ann Intern Med"},{"key":"pone.0317681.ref013","first-page":"1","author":"Minist\u00e9rio da Sa\u00fade","year":"2021"},{"issue":"17","key":"pone.0317681.ref014","doi-asserted-by":"crossref","first-page":"58","DOI":"10.53660\/CONJ-2188-2Z01","article-title":"Causas de descarte de c\u00f3rneas em bancos de tecido ocular humano: revis\u00e3o integrativa","volume":"22","author":"VGT Flores","year":"2022","journal-title":"Conjecturas"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T18:35:46Z","timestamp":1739212546000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317681"}},"subtitle":[],"editor":[{"given":"Eleftherios 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