{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:12:41Z","timestamp":1788999161374,"version":"build-2803163510"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019785","name":"Bangladesh University of Textiles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    <jats:italic>Tinospora cordifolia<\/jats:italic>\n                    extract exhibits diverse benefits\u2014anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>cordifolia<\/jats:italic>\n                    extraction. UV-Vis spectroscopy depicted an absorption range of 200\u2013400 nm, while FTIR analysis identified alcohols, phenols, amines, amides, aldehydes, ketones, alkanes, and alkenes. GC-MS analysis revealed the presence of components: 5methyl-5-Hexen-2-Ol, n-hexadecenoic acid, cholesta-4,6-dien-3beta-ol, stigmasterol, \u03b2-sitosterol, stearate which are present in the extract. Histopathological examination confirmed accelerated wound healing, showcasing reduced inflammation, restored blood vessels, collagen fibers, and swift epidermal closure.\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>cordifolia<\/jats:italic>\n                    extract exhibits promise in enhancing wound healing through its antibacterial, anti-inflammatory properties.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0317928","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:29:22Z","timestamp":1738157362000},"page":"e0317928","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract"],"prefix":"10.1371","volume":"20","author":[{"given":"Shohag Chandra","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrato","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olin","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abul Kalam","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujan Kumar","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Abdul","family":"Masum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-0557","authenticated-orcid":true,"given":"Sultana","family":"Bedoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"pone.0317928.ref001","author":"SS Mathew-steiner","year":"2021","journal-title":"Collagen in Wound Healing"},{"key":"pone.0317928.ref002","volume":"453","author":"GC Gurtner","year":"2008","journal-title":"Wound repair and regeneration"},{"key":"pone.0317928.ref003","first-page":"81","author":"H Sorg","year":"2017","journal-title":"Skin Wound Healing: An Update on the Current Knowledge and Concepts."},{"key":"pone.0317928.ref004","author":"NA Al-henhena","year":"2011","journal-title":"Histological study of wound healing potential by ethanol leaf extract of Strobilanthes crispus in rats"},{"key":"pone.0317928.ref005","first-page":"1","author":"CE Attinger","year":"2006","journal-title":"Wound Healing: An Overview."},{"issue":"265","key":"pone.0317928.ref006","volume":"6","author":"SA Eming","year":"2014","journal-title":"STATE OF THE ART REVIEW Wound repair and regeneration: Mechanisms, signaling, and translation."},{"issue":"4","key":"pone.0317928.ref007","first-page":"84","article-title":"Factors That Impair Wound Healing.","volume":"4","author":"K Anderson","year":"2014","journal-title":"J Am Coll Clin Wound Spec [Internet]."},{"issue":"August","key":"pone.0317928.ref008","doi-asserted-by":"crossref","first-page":"120286","DOI":"10.1016\/j.biomaterials.2020.120286","article-title":"Biomaterials ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds.","volume":"258","author":"H Zhao","year":"2020","journal-title":"Biomaterials [Internet]."},{"key":"pone.0317928.ref009","author":"R Poorniammal","year":"2022","journal-title":"Antimicrobial and wound healing potential of fungal pigments from Thermomyces sp. and Penicillium purpurogenum in wistar rats Antimicrobial and wound healing potential of fungal pigments from Thermomyces sp. and Penicillium purpurogenum in wistar rats."},{"issue":"36","key":"pone.0317928.ref010","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1016\/j.biomaterials.2011.08.080","article-title":"Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications.","volume":"32","author":"J Miao","year":"2011","journal-title":"Biomaterials"},{"key":"pone.0317928.ref011","article-title":"Advanced Journal of Chemistry-Section B Natural Products and Medical Chemistry Morphology, Biological Activity, Chemical Composition, and Medicinal Value of Tinospora Cordifolia (willd.)","author":"B Modi","year":"2020","journal-title":"Miers"},{"issue":"5","key":"pone.0317928.ref012","first-page":"363","article-title":"Tinospora cordifolia: The Antimicrobial Property of the Leaves of Amruthaballi","volume":"5","author":"KM Basalingappa","year":"2017","journal-title":"J Bacteriol Mycol Open Access"},{"key":"pone.0317928.ref013","first-page":"1","volume":"65","author":"A Shukla","year":"1999","journal-title":"In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica"},{"issue":"2","key":"pone.0317928.ref014","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/0972060X.2013.831568","article-title":"Determination of Chemical Composition and Evaluation of Antioxidant Activity of Essential Oil from Tinospora cordifolia (Willd.) Leaf.","volume":"17","author":"D Naik","year":"2014","journal-title":"J Essent Oil-Bearing Plants."},{"issue":"3","key":"pone.0317928.ref015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jep.2012.03.027","article-title":"Immunomodulatory active compounds from Tinospora cordifolia","volume":"141","author":"U Sharma","year":"2012","journal-title":"J Ethnopharmacol [Internet]."},{"issue":"00","key":"pone.0317928.ref016","first-page":"1","article-title":"Extraction and Characterization of Antimicrobial surgical Suture from the bast of Tinospora Cordifolia Extraction and Characterization of Antimicrobial surgical Suture from the bast of Tinospora Cordifolia.","volume":"00","author":"SC Das","year":"2022","journal-title":"J Nat Fibers [Internet]."},{"issue":"2","key":"pone.0317928.ref017","first-page":"299","article-title":"Chemistry and pharmacology of Tinospora cordifolia","volume":"12","author":"D Singh","year":"2017","journal-title":"Nat Prod Commun"},{"issue":"4","key":"pone.0317928.ref018","first-page":"101","volume":"2","author":"D Kumarasamyraja","year":"2012","journal-title":"A Review on Medicinal Plants with Potential Wound Healing Activity"},{"issue":"1","key":"pone.0317928.ref019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40816-019-0131-1","article-title":"Network pharmacology-based assessment to elucidate the molecular mechanism of anti-diabetic action of Tinospora cordifolia.","volume":"5","author":"P Khanal","year":"2019","journal-title":"Clin Phytoscience"},{"issue":"1","key":"pone.0317928.ref020","first-page":"119","volume":"1","author":"P Rev","year":"2007","journal-title":"PHCOG MAG.: Plant Review Recent trends in Curcuma Longa Linn."},{"key":"pone.0317928.ref021","author":"A Sharma","year":"2021","journal-title":"Medicinal plants and their components for wound healing applications"},{"issue":"1","key":"pone.0317928.ref022","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/2225-4110.124326","article-title":"Recent Scientific Studies of a Traditional Chinese Medicine, Tea, on Prevention of Chronic Diseases.","volume":"4","author":"CS Yang","year":"2014","journal-title":"J Tradit Complement Med [Internet]."},{"issue":"1","key":"pone.0317928.ref023","first-page":"56","volume":"6","author":"S Rani","year":"2016","journal-title":"REVIEW ARTICLE WOUND HEALING POTENTIAL OF MEDICINAL PLANTS WITH THEIR SCREENING MODELS: A COMPREHENSIVE REVIEW Inflammation Proliferation and Reconstruction Maturation and Remodeling."},{"issue":"6","key":"pone.0317928.ref024","first-page":"181","volume":"3","year":"2013","journal-title":"The Wound Healing Effects of Aqueous Leave Extracts of Azadirachta Indica on Wistar Rats"},{"issue":"November","key":"pone.0317928.ref025","first-page":"777","volume":"46","author":"K Kiran","year":"2008","journal-title":"Wound healing activity of Sesamum indicum L seed and oil in rats."},{"key":"pone.0317928.ref026","first-page":"83","author":"BS Nayak","journal-title":"Wound-healing activity of."},{"issue":"12","key":"pone.0317928.ref027","doi-asserted-by":"crossref","first-page":"e11843","DOI":"10.1016\/j.heliyon.2022.e11843","article-title":"Chemical analysis of essential oil extracted from pomelo sourced from Bangladesh.","volume":"8","author":"S Chandra Das","year":"2022","journal-title":"Heliyon [Internet]."},{"issue":"12","key":"pone.0317928.ref028","first-page":"2020","article-title":"Phytochemical screening, FT-IR and gas chromatography mass spectrometry analysis of Tinospora cordifolia (Thunb.) Miers.","volume":"8","author":"R Papitha","year":"2016","journal-title":"Int J Pharmacogn Phytochem Res"},{"issue":"9","key":"pone.0317928.ref029","doi-asserted-by":"crossref","first-page":"e02437","DOI":"10.1016\/j.heliyon.2019.e02437","article-title":"The chemical constituents and diverse pharmacological importance of Tinospora cordifolia.","volume":"5","author":"P Sharma","year":"2019","journal-title":"Heliyon [Internet]."},{"issue":"1","key":"pone.0317928.ref030","article-title":"Aloe vera\u2014mediated silver-selenium doped fucoidan nanocomposites synthesis and their multi-faceted biological evaluation of antimicrobial, antioxidant and cytotoxicity activity.","volume":"39","author":"M Surya","year":"2024","journal-title":"Mater Technol [Internet]."},{"issue":"1","key":"pone.0317928.ref031","article-title":"Melothria maderaspatana mediated one-pot synthesis of cerium-doped Silymarin nanoparticles and their antibacterial and anticancer studies.","volume":"39","author":"P Aaditya Marthandan","year":"2024","journal-title":"Mater Technol [Internet]."},{"issue":"8","key":"pone.0317928.ref032","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.1007\/s13399-023-05265-8","article-title":"Tridax procumbens\u2013mediated one pot synthesis of silver-doped fucoidan nanoparticles and their antibacterial, antioxidant, and anti-inflammatory efficacy.","volume":"14","author":"A Mathesh","year":"2024","journal-title":"Biomass Convers Biorefinery"},{"key":"pone.0317928.ref033","first-page":"3738","article-title":"F TIR, Uv- Vis And GCMS Analysis Of Potential Bioactive Compounds From Tinospora Cordifolia And Its Antibacterial Activity","volume":"10","author":"YL Ramachandra","year":"2023"},{"key":"pone.0317928.ref034","first-page":"37","article-title":"Optical effect pigments for technical textile applications.","author":"N. Sekar","year":"2013","journal-title":"Adv Dye Finish Tech Text."},{"key":"pone.0317928.ref035","doi-asserted-by":"crossref","DOI":"10.1063\/5.0053057","article-title":"Phytochemical analysis of bioactive compounds in ethanolic extract of Sterculia quadrifida R.Br.","volume":"2353","author":"S Siswadi","year":"2021","journal-title":"AIP Conf Proc"},{"issue":"8","key":"pone.0317928.ref036","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S1671-2927(09)60212-1","article-title":"Antibacterial activity of 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester from neem oil.","volume":"9","author":"Pu Z hui","year":"2010","journal-title":"Agric Sci China [Internet]."},{"issue":"1","key":"pone.0317928.ref037","doi-asserted-by":"crossref","first-page":"123","DOI":"10.21010\/ajtcam.v14i1.13","article-title":"Evaluation of the Anti-Inflammatory Capacity of Beta-Sitosterol in Rodent Assays.","volume":"14","author":"R Paniagua-P\u00e9rez","year":"2017","journal-title":"African J Tradit Complement Altern Med AJTCAM"},{"key":"pone.0317928.ref038","first-page":"2022","article-title":"(E)-9-Octadecenoic Acid Ethyl Ester Derived from Lotus Seedpod Ameliorates Inflammatory Responses by Regulating MAPKs and NF- B Signalling Pathways in LPS-Induced RAW264.7 Macrophages.","author":"C Xie","year":"2022","journal-title":"Evidence-based Complement Altern Med"},{"issue":"3","key":"pone.0317928.ref039","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1747-0285.2012.01418.x","article-title":"Anti-Inflammatory Property of n-Hexadecanoic Acid: Structural Evidence and Kinetic Assessment","volume":"80","author":"V Aparna","year":"2012","journal-title":"Chem Biol Drug Des"},{"issue":"7","key":"pone.0317928.ref040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/wound.2017.0761","article-title":"Immune regulation of skin wound healing: Mechanisms and novel therapeutic targets.","volume":"7","author":"J Larouche","year":"2018","journal-title":"Adv Wound Care"},{"issue":"10","key":"pone.0317928.ref041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox11101912","article-title":"Health Benefits and Pharmacological Properties of Stigmasterol.","volume":"11","author":"S Bakrim","year":"2022","journal-title":"Antioxidants."},{"issue":"1","key":"pone.0317928.ref042","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejmech.2007.03.015","article-title":"N-[2-(5,5-Dimethyl-1,3-dioxane-2-yl)ethyl]amino acids: Their synthesis, anti-inflammatory evaluation and QSAR analysis.","volume":"43","author":"X Li","year":"2008","journal-title":"Eur J Med Chem"},{"issue":"12","key":"pone.0317928.ref043","doi-asserted-by":"crossref","first-page":"15587","DOI":"10.3390\/molecules181215587","article-title":"Antimicrobial and antioxidant activities and effect of 1-hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus berkleasmium sp. Dzf12.","volume":"18","author":"Y Mou","year":"2013","journal-title":"Molecules"},{"issue":"1","key":"pone.0317928.ref044","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/1534734620924857","article-title":"A Systematic Review on Classification, Identification, and Healing Process of Burn Wound Healing.","volume":"21","author":"M Abazari","year":"2022","journal-title":"Int J Low Extrem Wounds."},{"issue":"7 SUPPL.","key":"pone.0317928.ref045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/01.prs.0000225430.42531.c2","article-title":"The basic science of wound healing","volume":"117","author":"G Broughton","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"20","key":"pone.0317928.ref046","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: a critical step during wound healing","volume":"73","author":"NX Land\u00e9n","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"pone.0317928.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/146764","article-title":"Complements and the Wound Healing Cascade: An Updated Review.","volume":"2013","author":"H Sinno","year":"2013","journal-title":"Plast Surg Int."},{"key":"pone.0317928.ref048","doi-asserted-by":"crossref","DOI":"10.5772\/64611","article-title":"Roles of Matrix Metalloproteinases in Cutaneous Wound Healing.","author":"TT Nguyen","year":"2016","journal-title":"Wound Heal\u2014New insights into Anc Challenges"},{"issue":"16","key":"pone.0317928.ref049","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/nu14163336","article-title":"Accelerating Effect of Cucurbita pepo L. Fruit Extract on Excisional Wound Healing in Depressed Rats Is Mediated through Its Anti-Inflammatory and Antioxidant Effects.","volume":"14","author":"HM Almohaimeed","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"pone.0317928.ref050","doi-asserted-by":"crossref","first-page":"286","DOI":"10.5114\/ada.2021.103459","article-title":"L. Cucurbita pepo modulates contact dermatitis in depressed rats through downregulation of proinflammatory cytokines and upregulation of antioxidant status.","volume":"39","author":"N Ayuob","year":"2022","journal-title":"Advances in Dermatology and Allergology\/Post\u0119py Dermatologii i Alergologii."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:29:40Z","timestamp":1738157380000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0317928"}},"subtitle":[],"editor":[{"given":"Faham","family":"Khamesipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0317928","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}