{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:42:56Z","timestamp":1776451376479,"version":"3.51.2"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Music therapy has been increasingly incorporated into psychiatric inpatient care as an adjunctive intervention; however, evidence regarding its comparative effectiveness, particularly with respect to intervention intensity during brief psychiatric hospitalizations, remains limited. Most randomized trials have evaluated interventions delivered over several weeks, leaving uncertainty about the potential differential effects of higher versus lower intervention intensity within short inpatient stays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial with a parallel-group design was conducted in an adult psychiatric inpatient unit in Bogot\u00e1, Colombia. Participants were randomly assigned (1:1) to either a high-frequency music therapy group, which received five sessions delivered on consecutive days within a single inpatient week, or a low-frequency group, which received one session during the same period. Allocation concealment was ensured through computer-generated randomization performed by an independent researcher not involved in participant recruitment or outcome assessment.<\/jats:p>\n                    <jats:p>Primary outcomes were symptoms of depression, anxiety, and stress, assessed using the Depression Anxiety Stress Scale\u201321 (DASS-21) at baseline and at the end of the intervention week. Secondary outcomes included emotional responses to music therapy, assessed using selected items from the Questionnaire of the Impact of Music Therapy Sessions in Adults (CISMA instrument), and global life satisfaction, measured with the Satisfaction With Life Scale (SWLS). Between-group changes over time were analyzed using repeated-measures mixed-effects linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 91 participants were randomized, of whom 74 (37 per group) completed post-intervention assessments and were included in the per-protocol analysis. Between-group analyses revealed a statistically significant group\u2009\u00d7\u2009time interaction for the DASS-21 stress subscale only. Participants in the high-frequency music therapy group showed a greater reduction in stress scores compared with the low-frequency group, with a statistical between-group difference (6.49\u2009\u00b1\u20095.55 vs. 7.03\u2009\u00b1\u20095.81; p\u2009=\u20090.023).<\/jats:p>\n                    <jats:p>No statistically significant between-group differences were observed for the DASS-21 anxiety subscale (p\u2009=\u20090.339) or the depression subscale (p\u2009=\u20090.270). Global life satisfaction, as measured by the SWLS, did not differ significantly between groups (p\u2009&gt;\u20090.05). For secondary outcomes assessed using selected CISMA items related to emotional change, between-group differences were small and not statistically significant across all items. Overall, except for stress symptoms, outcomes did not differ significantly between the high-frequency and low-frequency intervention groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this randomized controlled trial, a higher frequency of music therapy sessions was associated with a greater reduction in stress symptoms compared with a lower-frequency intervention during a brief psychiatric hospitalization. However, no between-group differences were observed for anxiety, depression, life satisfaction, or emotional response measures. Overall, these findings indicate limited evidence of differential effectiveness by intervention intensity and should be interpreted cautiously in light of the study\u2019s methodological limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ISRCTN registry: ISRCTN87861817 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.isrctn.com\/ISRCTN87861817\" xlink:type=\"simple\">https:\/\/www.isrctn.com\/ISRCTN87861817<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0317950","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:50:13Z","timestamp":1776448213000},"page":"e0317950","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-frequency vs. low-frequency MIDI-assisted group music therapy in psychiatric inpatients: A randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"given":"Manuel","family":"Esteban-C\u00e1rdenas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"G\u00f3mez-Puentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Torres-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Hidalgo-Valbuena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-7696","authenticated-orcid":true,"given":"Eugenio","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"issue":"6","key":"pone.0317950.ref001","first-page":"52","article-title":"The role of music therapy in psychiatry","volume":"11","author":"A De Sousa","year":"2005","journal-title":"Altern Ther Health Med"},{"key":"pone.0317950.ref002","author":"American Music Therapy Association","year":"2005"},{"key":"pone.0317950.ref003","doi-asserted-by":"crossref","first-page":"104437","DOI":"10.1016\/j.ijnurstu.2023.104437","article-title":"Effects of non-pharmacological interventions on psychological outcomes among older people with frailty: A systematic review and meta-analysis","volume":"140","author":"A Tao","year":"2023","journal-title":"Int J Nurs Stud"},{"issue":"3","key":"pone.0317950.ref004","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4187\/respcare.07489","article-title":"Music Therapy in Adults With COPD","volume":"66","author":"J Huang","year":"2021","journal-title":"Respir Care"},{"issue":"4","key":"pone.0317950.ref005","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/eurpub\/ckad063","article-title":"The role of music in promoting health and wellbeing: a systematic review and meta-analysis","volume":"33","author":"E Viola","year":"2023","journal-title":"Eur J Public Health"},{"issue":"2","key":"pone.0317950.ref006","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/ijerph20021046","article-title":"Effects of Music-Based Interventions on Motor and Non-Motor Symptoms in Patients with Parkinson\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"20","author":"H Lee","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"pone.0317950.ref007","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/jan.14630","article-title":"Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials","volume":"77","author":"W Yue","year":"2021","journal-title":"J Adv Nurs"},{"issue":"2","key":"pone.0317950.ref008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/135945751502900207","article-title":"The music in music therapy psychodynamic music therapy in Europe","volume":"29","author":"J Sutton","year":"2015","journal-title":"British Journal of Music Therapy"},{"issue":"10","key":"pone.0317950.ref009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/medicina56100526","article-title":"Music therapy in pain and anxiety management during labor: a systematic review and meta-analysis","volume":"56","author":"R Santiv\u00e1\u00f1ez-Acosta","year":"2020","journal-title":"Medicina"},{"issue":"8","key":"pone.0317950.ref010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0307661","article-title":"The effectiveness of live music in reducing anxiety and depression among patients undergoing haemodialysis. 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