{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:30:08Z","timestamp":1787589008414,"version":"build-2736575974"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2020 FI_B1 00195"],"award-info":[{"award-number":["2020 FI_B1 00195"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Centro para el Desarrollo Tecnol\u00f3gico Industrial","doi-asserted-by":"publisher","award":["SNEO-20191281"],"award-info":[{"award-number":["SNEO-20191281"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017642","name":"Spanish National Plan for Scientific and Technical Research and Innovation","doi-asserted-by":"publisher","award":["PTQ2018-010227"],"award-info":[{"award-number":["PTQ2018-010227"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Wearable exoskeletons are emerging as a new tool for gait training. However, comparisons between exoskeletons and conventional orthoses in terms of safety and feasibility are scarce. This study assessed the safety, feasibility, usability, and learning process of using the ABLE Exoskeleton in people with spinal cord injury (SCI) while comparing it with knee-ankle-foot orthoses (KAFOs). In this randomized, crossover clinical trial, 10 patients with chronic complete SCI (T4-T12) conducted a 10-session training and assessment protocol with each device: KAFOs and the ABLE Exoskeleton. Outcomes on safety (adverse events), and feasibility and usability (level of assistance, donning\/doffing, therapy activities) were recorded for both devices. Evaluation sessions included standard clinical tests (Timed Up and Go, 10-Meter Walk Test, and 6-Minute Walk Test) to assess gait performance. The therapy metrics (number of steps, distance, gait speed, and standing and walking time) were recorded at each session for the robotic device. Participants quickly learned how to use the ABLE Exoskeleton, showing improvements in all therapy metrics (p&lt;0.05) and the 6-Minute Walk Test (p&lt;0.05). Participants reported less adverse events with the robotic device than KAFOs (17 and 31, respectively). Total donning and doffing time was 43\u2009s faster with the robotic device using comparable levels of assistance. The time to complete the therapy activities was very similar between devices. Overall, participants needed 1 to 4 training sessions to perform essential therapy activities (sit\/stand transitions, walking 10 meters, turning around) with both devices using minimum assistance or less. The results of this study show that it is feasible and safe for people with motor complete paraplegia due to SCI (T4-T12) to use the ABLE Exoskeleton for gait training in a rehabilitation hospital setting. The ABLE Exoskeleton proved to be as practical and easy to use as conventional orthoses, with fewer AEs reported when using the exoskeleton versus the KAFOs.<\/jats:p>","DOI":"10.1371\/journal.pone.0318039","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:58:06Z","timestamp":1748354286000},"page":"e0318039","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Randomized, crossover clinical trial on the safety, feasibility, and usability of the ABLE exoskeleton: A comparative study with knee-ankle-foot 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Middleton","year":"1999","journal-title":"Arch Phys Med Rehabil"},{"key":"pone.0318039.ref048","first-page":"1","volume-title":"Prevention and treatment of pressure ulcers\/injuries: Quick reference guide 2019 disclaimer","year":"2009"},{"issue":"12","key":"pone.0318039.ref049","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0003-9993(96)90184-7","article-title":"The reliability of the functional independence measure: A quantitative review","volume":"77","author":"KJ Ottenbacher","year":"1996","journal-title":"Arch Phys Med Rehabil"},{"issue":"15","key":"pone.0318039.ref050","first-page":"276","article-title":"On the proper use of the crossover design in clinical trials: Part 18 of a series on evaluation of scientific publications","volume":"109","author":"S Wellek","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"pone.0318039.ref051","volume-title":"Ecological models and data in R","author":"BM 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