{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:51:46Z","timestamp":1789750306144,"version":"4.0.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic heart disease (IHD) has a significant impact on public health and healthcare expenditures in the United States (US).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the CDC WONDER database from 1999\u20132020 to identify trends in the IHD-related mortality of patients \u2265 75 years in the US. AAMRs per 100,000 population and APC were calculated and categorized by year, sex, race, and geographic divisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 1999 and 2020, a total of 8,124,568 IHD-related deaths were recorded. Notable declines in AAMR were observed from 1999 to 2014 (APC: -3.86) and from 2014 to 2018 (APC: -2.55), with an overall increase from 2018 to 2020 (APC: 3.76). Older men consistently demonstrated higher AAMRs than older females, with AAMRs for both sexes decreasing steadily from 1999 to 2018 and increasing in 2020. When stratified by race\/ethnicity, Whites (1931.7) had the highest AAMR, followed by Blacks (1836.5), American Indians (1510.5), Hispanics (1464.4), and Asians (1093.6). Furthermore, nonmetropolitan areas (2015.2) showed greater AAMRs than metropolitan areas (1841.8). The \u2265 85-year group consistently exhibited higher IHD-related mortality rates compared to the 75\u201384 years group. In comparison, the older group [\u226575 years] (1873.0) consistently exhibited higher IHD-related AAMRs than the younger group [&lt;75 years] (64.0) throughout the study, showing a significant disparity. Chronic IHD (1552.0) consistently showed the highest AAMRs throughout the study, surpassing myocardial infarction (515.6), other ischemic heart diseases (24.0), and angina pectoris (5.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeted interventions and resource allocation are crucial for areas with high IHD-related mortality. Public health policies should address demographic and geographical disparities, with further research for effective strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0318073","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T14:10:57Z","timestamp":1737727857000},"page":"e0318073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Demographics and regional trends of ischemic heart disease-related mortality in older adults in the United States, 1999\u20132020"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1509-2214","authenticated-orcid":true,"given":"Fakhar","family":"Latif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Moiz","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajeeh Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-0221","authenticated-orcid":true,"given":"Mohammed","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-3435","authenticated-orcid":true,"given":"Jishanth","family":"Mattumpuram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komail Khalid","family":"Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helme","family":"Silvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Yarkoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamed Amr","family":"Sabouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Braiteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyoor","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-4119","authenticated-orcid":true,"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"pone.0318073.ref001","doi-asserted-by":"crossref","first-page":"358","DOI":"10.25121\/PNM.2018.31.6.358","article-title":"Ischemic heart disease\u2013definition, epidemiology, pathogenesis, risk factors and treatment","volume":"31","author":"M Kasprzyk","year":"2018","journal-title":"Post\u0119py Nauk Medycznych"},{"key":"pone.0318073.ref002","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.amjmed.2022.08.002","article-title":"New Coronary Heart Disease Risk Factors","volume":"136","author":"JS Alpert","year":"2023","journal-title":"The American Journal of Medicine"},{"key":"pone.0318073.ref003","first-page":"12","article-title":"Global, Regional, and National Burdens of Ischemic Heart Disease Attributable to Smoking From 1990 to 2019","author":"L Zhang","year":"2023","journal-title":"Journal of the American Heart Association"},{"key":"pone.0318073.ref004","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.amjmed.2011.04.010","article-title":"The impact of the aging population on coronary heart disease in the United States","volume":"124","author":"MC Odden","year":"2011","journal-title":"The American journal of medicine"},{"key":"pone.0318073.ref005","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ijcard.2013.12.028","article-title":"The annual global economic burden of heart failure","volume":"171","author":"C Cook","year":"2014","journal-title":"International journal of cardiology"},{"key":"pone.0318073.ref006","doi-asserted-by":"crossref","first-page":"e191938","DOI":"10.1001\/jamanetworkopen.2019.1938","article-title":"Twenty-Year Trends in Outcomes for Older Adults With Acute Myocardial Infarction in the United States","volume":"2","author":"HM Krumholz","year":"2019","journal-title":"JAMA Network Open"},{"key":"pone.0318073.ref007","unstructured":"Centers for Disease Control and Prevention, National Center for Health Statistics. 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